IN2014CN03411A - - Google Patents

Info

Publication number
IN2014CN03411A
IN2014CN03411A IN3411CHN2014A IN2014CN03411A IN 2014CN03411 A IN2014CN03411 A IN 2014CN03411A IN 3411CHN2014 A IN3411CHN2014 A IN 3411CHN2014A IN 2014CN03411 A IN2014CN03411 A IN 2014CN03411A
Authority
IN
India
Prior art keywords
magnetic field
binding surface
magnetic particles
bound
attractive
Prior art date
Application number
Inventor
Joannes Baptist Adrianus Dionisius Van Zon
Ron Martinus Laurentius Van Lieshout
Original Assignee
Koninkl Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Nv filed Critical Koninkl Philips Nv
Publication of IN2014CN03411A publication Critical patent/IN2014CN03411A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

The invention relates to a method and a sensor device (100) for the detection of magnetic particles (1) bound to the binding surface (111) of a sample chamber (112) wherein said detection is made during and/or immediately after the action of an attractive magnetic field. Preferably the attractive magnetic field (B) is preceded by a repulsive magnetic field (B) which removes unbound magnetic particles away from the binding surface (111). Due to the attractive magnetic field (B) bound magnetic particles (1) come closer to the binding surface (111) which increases the signal of surface specific detection techniques like frustrated total internal reflection. A further enhancement of the signal can be achieved by an attractive magnetic field that is parallel to the binding surface (111) thus inducing the generation of chains between unbound and bound magnetic particles.
IN3411CHN2014 2011-11-03 2012-10-31 IN2014CN03411A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161555147P 2011-11-03 2011-11-03
PCT/IB2012/056044 WO2013064990A1 (en) 2011-11-03 2012-10-31 Detection of surface-bound magnetic particles

Publications (1)

Publication Number Publication Date
IN2014CN03411A true IN2014CN03411A (en) 2015-10-09

Family

ID=47520169

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3411CHN2014 IN2014CN03411A (en) 2011-11-03 2012-10-31

Country Status (7)

Country Link
US (1) US9488647B2 (en)
EP (1) EP2773946B1 (en)
JP (1) JP6154393B2 (en)
CN (1) CN103907012B (en)
IN (1) IN2014CN03411A (en)
MX (1) MX337944B (en)
WO (1) WO2013064990A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6594995B2 (en) 2015-03-26 2019-10-23 コーニンクレッカ フィリップス エヌ ヴェ Manufacture of biosensor cartridge
CN105929149B (en) * 2016-04-26 2018-09-11 中国科学院电子学研究所 A kind of optical detector based on magnetic enrichment and total internal reflection
CN106596473A (en) * 2016-10-27 2017-04-26 中国科学院电子学研究所 Optic detector based on electric control magnet enrichment-separation and total internal reflection magnetic imaging
US12000783B2 (en) * 2019-07-11 2024-06-04 Citizen Watch Co., Ltd. Device for detecting substance being measured

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491068A (en) 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
AU2004273783A1 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
CN101111769A (en) * 2005-01-31 2008-01-23 皇家飞利浦电子股份有限公司 Rapid and sensitive biosensing
US20090227044A1 (en) 2006-01-26 2009-09-10 Dosi Dosev Microchannel Magneto-Immunoassay
US20090219012A1 (en) * 2006-05-09 2009-09-03 Koninklijke Philips Electronics N.V. Microelectronic sensor device for concentration measurements
CN101490528A (en) * 2006-07-17 2009-07-22 皇家飞利浦电子股份有限公司 Attraction and repulsion of magnetic of magnetizable objects to and from a sensor surface
WO2008072156A2 (en) * 2006-12-12 2008-06-19 Koninklijke Philips Electronics N. V. Microelectronic sensor device for detecting label particles
WO2008084343A1 (en) * 2007-01-12 2008-07-17 Koninklijke Philips Electronics N. V. A sensor device for and a method of sensing particles
WO2008155716A1 (en) 2007-06-21 2008-12-24 Koninklijke Philips Electronics N. V. Microelectronic sensor device for detecting label particles
US20110007178A1 (en) * 2008-03-12 2011-01-13 Koninklijke Philips Electronics N.V. Correction of spot area in measuring brightness of sample in biosensing device
EP2265953A1 (en) 2008-04-11 2010-12-29 Koninklijke Philips Electronics N.V. Detection apparatus for detecting particles
EP2329269A1 (en) 2008-09-26 2011-06-08 Koninklijke Philips Electronics N.V. Magnetic-label sensor and cartridge
RU2520607C2 (en) * 2008-10-17 2014-06-27 Конинклейке Филипс Электроникс Н.В. Actuation with pulsed magnetic field for sensitive analysis
RU2519655C2 (en) * 2008-11-19 2014-06-20 Конинклейке Филипс Электроникс Н.В. Biosensor system for actuating magnetic particles
RU2491540C2 (en) * 2009-01-22 2013-08-27 Конинклейке Филипс Электроникс Н.В. Compound excitation protocol for magnetic biosensor device
CN102575976B (en) * 2009-09-28 2016-03-30 皇家飞利浦电子股份有限公司 Substance determining apparatus
WO2011036634A1 (en) * 2009-09-28 2011-03-31 Koninklijke Philips Electronics N.V. A biosensor system for single particle detection

Also Published As

Publication number Publication date
WO2013064990A1 (en) 2013-05-10
CN103907012A (en) 2014-07-02
EP2773946B1 (en) 2021-08-25
MX337944B (en) 2016-03-29
US20140287533A1 (en) 2014-09-25
CN103907012B (en) 2018-02-16
MX2014005193A (en) 2014-05-28
US9488647B2 (en) 2016-11-08
JP2014532872A (en) 2014-12-08
JP6154393B2 (en) 2017-06-28
EP2773946A1 (en) 2014-09-10

Similar Documents

Publication Publication Date Title
HK1259303A1 (en) Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
HK1199506A1 (en) System and method of processing a sound signal including transforming the sound signal into a frequency-chirp domain
IT1399311B1 (en) METHOD OF DETERMINING THE CLOSING INSTANT OF AN ELECTROMAGNETIC FUEL INJECTOR
GB2479501B (en) Enhanced method and device for aquatic seismic prospecting
EP2352041A4 (en) Method for quantitatively separating the effects of electromagnetic induction and induced polarization
HK1212383A1 (en) Pr13.5 promoter for robust t-cell and antibody responses t pr135
BRPI0913152A2 (en) "Time domain electromagnetic geophysical scanning system and method for signal processing"
IN2014CN03411A (en)
PL2387627T3 (en) Adaptive immunity profiling and methods for generation of monoclonal antibodies
ZA201000093B (en) Detection of antigens carried by erythrocytes and of anti-erythrocyte antibodies
WO2008020365A3 (en) Magnetic sensor device
PT1800753E (en) Method and device for separating solid particles on the basis of a difference in density
MX2017001905A (en) Signal amplification in plasmonic specific-binding partner assays.
IL266452B (en) Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
IN2014CN02659A (en)
WO2012033291A3 (en) Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same
WO2013068569A3 (en) Assembly for transferring structure-borne sound waves to a body
NZ605706A (en) Method for detecting molecular interactions
EP2536817A4 (en) Immunoassay device for detecting antibodies and antigens
EA201390599A1 (en) METHOD AND DEVICE FOR PROCESSING LIQUID IN A PIPELINE BY HIGH-FREQUENCY SIGNALS
ZA201202408B (en) Sensor device and method for the geoelectrical prospecting of raw mineral deposits
DE112012004046T8 (en) Device for detecting an electromagnetic wave
GB201201445D0 (en)
IL212771A0 (en) Method of determining the direction of arrival of an electromagnetic wave
GB2466764B (en) Method for enhanced subsurface electromagnetic sensitivity