IN2013DE02956A - - Google Patents
Info
- Publication number
- IN2013DE02956A IN2013DE02956A IN2956DE2013A IN2013DE02956A IN 2013DE02956 A IN2013DE02956 A IN 2013DE02956A IN 2956DE2013 A IN2956DE2013 A IN 2956DE2013A IN 2013DE02956 A IN2013DE02956 A IN 2013DE02956A
- Authority
- IN
- India
- Prior art keywords
- osletamivir
- imidazothiazolone
- amidoalkylation
- ramberg
- tamiflu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention discloses an economic, simple, azide and aziridine complexity free process for the synthesis of osletamivir phosphate (Tamiflu) by stereospecific amidoalkylation of imidazothiazolone from easily available L-cysteine via Ramberg-Backlund reaction and Sharpless-Reich protocol.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016520012A JP6474392B2 (en) | 2013-10-04 | 2014-10-07 | Method for preparing an intermediate for the preparation of oseltamivir phosphate |
EP14811991.0A EP3052473B1 (en) | 2013-10-04 | 2014-10-07 | A process for the preparation of intermediate for the preparation of oseltamivir phosphate |
IN2956DE2013 IN2013DE02956A (en) | 2013-10-04 | 2014-10-07 | |
US15/026,376 US9522922B2 (en) | 2013-10-04 | 2014-10-07 | Process for the preparation of intermediate for the preparation of oseltamivir phosphate |
PCT/IN2014/000645 WO2015049700A1 (en) | 2013-10-04 | 2014-10-07 | A process for the preparation of intermediate for the preparation of oseltamivir phosphate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2956DE2013 IN2013DE02956A (en) | 2013-10-04 | 2014-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013DE02956A true IN2013DE02956A (en) | 2015-04-10 |
Family
ID=52023584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2956DE2013 IN2013DE02956A (en) | 2013-10-04 | 2014-10-07 |
Country Status (5)
Country | Link |
---|---|
US (1) | US9522922B2 (en) |
EP (1) | EP3052473B1 (en) |
JP (1) | JP6474392B2 (en) |
IN (1) | IN2013DE02956A (en) |
WO (1) | WO2015049700A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110506045B (en) * | 2017-04-12 | 2023-01-13 | 帝斯曼知识产权资产管理有限公司 | Process for preparing imidazothiazolone compounds |
WO2018233562A1 (en) * | 2017-06-20 | 2018-12-27 | 广东东阳光药业有限公司 | Method for preparing oseltamivir and isomer thereof |
US10385010B1 (en) * | 2018-03-28 | 2019-08-20 | Georgia State University Research Foundation, Inc. | Expedient synthesis of oseltamivir and related compounds via direct olefin diazidation-diamidation reaction |
CN111349059B (en) * | 2018-12-20 | 2023-03-31 | 中国科学院上海药物研究所 | Preparation method of chiral epoxy compound |
CN113307744A (en) * | 2021-05-29 | 2021-08-27 | 弘健制药(上海)有限公司 | Preparation method of oseltamivir phosphate |
CN114478290A (en) * | 2022-01-24 | 2022-05-13 | 广东中润药物研发有限公司 | Synthetic method of oseltamivir intermediate |
CN116396306A (en) * | 2023-04-13 | 2023-07-07 | 华东理工大学 | Preparation method of D-biotin key intermediate thiolactone |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486328B1 (en) * | 2000-10-12 | 2002-11-26 | Council Of Scientific And Industrial Research | Substituted 2-[-6-benzyl-5-oxo-3-phenyl-(3s,7s, 7aR)-perhydroimidazol[1,5-c][1,3]thiazol-7yl] compounds |
JPWO2007099843A1 (en) | 2006-02-23 | 2009-07-16 | 国立大学法人 東京大学 | α, β-Unsaturated cyclohexanone derivative, method for producing the same, and method for producing the intermediate |
JP2008081489A (en) | 2006-08-31 | 2008-04-10 | Univ Of Tokyo | Cyclic urethane compound and method for producing the same |
-
2014
- 2014-10-07 IN IN2956DE2013 patent/IN2013DE02956A/en unknown
- 2014-10-07 WO PCT/IN2014/000645 patent/WO2015049700A1/en active Application Filing
- 2014-10-07 JP JP2016520012A patent/JP6474392B2/en not_active Expired - Fee Related
- 2014-10-07 EP EP14811991.0A patent/EP3052473B1/en not_active Not-in-force
- 2014-10-07 US US15/026,376 patent/US9522922B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9522922B2 (en) | 2016-12-20 |
WO2015049700A1 (en) | 2015-04-09 |
EP3052473A1 (en) | 2016-08-10 |
US20160222029A1 (en) | 2016-08-04 |
JP2016537315A (en) | 2016-12-01 |
EP3052473B1 (en) | 2018-01-17 |
JP6474392B2 (en) | 2019-02-27 |
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