IN2013DE00343AIN343DE2013AIN2013DE00343AIN 2013DE00343 AIN2013DE00343 AIN 2013DE00343AIN 343DE2013 AIN343DE2013 AIN 343DE2013AIN 2013DE00343 AIN2013DE00343 AIN 2013DE00343A
Authority
IN
India
Prior art keywords
carbonyl
amino
methyl
dabigatran etexilate
iminomethyl
Prior art date
Application number
Inventor
Bharat Varu
Satish Kumar
Sanjay Kumar Pandey
Jayant Srivastava
Hari Babu Matta
Khushwant Singh
Dharam Vir
Original Assignee
Jubilant Life Sciences Ltd
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Filing date
Publication date
Application filed by Jubilant Life Sciences LtdfiledCriticalJubilant Life Sciences Ltd
Priority to IN343DE2013priorityCriticalpatent/IN2013DE00343A/en
Publication of IN2013DE00343ApublicationCriticalpatent/IN2013DE00343A/en
The present invention relates to the process for the preparation of N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl ethyl ester known as dabigatran etexilate and its methanesulfonate salt commonly known as dabigatran etexilate mesylate (Ia) employing the use of novel intermediate of formula (V) and (VI).
Synthesis process, and crystalline form of 4-(3-(cis-hexahydrocyclopenta(c)pyrrol-2(1h)-yl)propoxy)benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them