IN2013CN00536A - - Google Patents

Info

Publication number
IN2013CN00536A
IN2013CN00536A IN536CHN2013A IN2013CN00536A IN 2013CN00536 A IN2013CN00536 A IN 2013CN00536A IN 536CHN2013 A IN536CHN2013 A IN 536CHN2013A IN 2013CN00536 A IN2013CN00536 A IN 2013CN00536A
Authority
IN
India
Prior art keywords
protein
hpv52
truncated
vlp
infection
Prior art date
Application number
Inventor
Shaowei Li
Xiaobing Mo
Minxi Wei
Huirong Pan
Jun Zhang
Ningshao Xia
Original Assignee
Univ Xiamen
Xiamen Innovax Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Xiamen, Xiamen Innovax Biotech Co Ltd filed Critical Univ Xiamen
Publication of IN2013CN00536A publication Critical patent/IN2013CN00536A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Provided is a truncated L1 protein of human papillomavirus (HPV) type 52 which compared to a wild type HPV52 L1 protein is truncated by 27 42 amino acids at the N terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein a virus like particle (VLP) comprising the protein and a method of preparing the protein and the VLP using an Escherichia coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and HPV52 infection induced diseases such as cervical cancer.
IN536CHN2013 2010-07-02 2011-07-01 IN2013CN00536A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010216189 2010-07-02
PCT/CN2011/076763 WO2012000454A1 (en) 2010-07-02 2011-07-01 Truncated l1 protein of human papillomavirus type 52

Publications (1)

Publication Number Publication Date
IN2013CN00536A true IN2013CN00536A (en) 2015-07-03

Family

ID=45050553

Family Applications (1)

Application Number Title Priority Date Filing Date
IN536CHN2013 IN2013CN00536A (en) 2010-07-02 2011-07-01

Country Status (7)

Country Link
US (1) US9499591B2 (en)
EP (1) EP2589604B1 (en)
CN (1) CN102268076B (en)
BR (1) BR112013000031A2 (en)
DK (1) DK2589604T3 (en)
IN (1) IN2013CN00536A (en)
WO (1) WO2012000454A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044531B (en) * 2012-09-29 2014-07-30 重庆原伦生物科技有限公司 Purification method of methicillin-resistant staphylococcus aureus (MREA)-resistant vaccine recombinant protein antigen HI2
CN106701796B (en) * 2015-08-12 2021-11-16 北京康乐卫士生物技术股份有限公司 52 type recombinant human papilloma virus-like particle and preparation method thereof
CN105985934A (en) * 2015-08-18 2016-10-05 北京康乐卫士生物技术股份有限公司 Divalent, trivalent or multivalent HPV pseudovirus and application thereof
WO2017092710A1 (en) * 2015-12-04 2017-06-08 厦门大学 Mutant of human papillomavirus type 58 l1 protein
CN106831959B (en) * 2015-12-04 2019-11-05 厦门大学 A kind of mutant of human papillomavirus 33 type L 1 protein
CN107557347B (en) * 2016-06-30 2022-03-29 中国科学院上海巴斯德研究所 Novel enterovirus 71-type virus-like particle, preparation method and application thereof
WO2021013071A1 (en) * 2019-07-19 2021-01-28 神州细胞工程有限公司 Polyvalent immunogenicity composition for human papillomavirus
WO2021013078A1 (en) * 2019-07-19 2021-01-28 神州细胞工程有限公司 Chimeric human papilloma virus 52 type l1 protein
CN114539365B (en) * 2020-11-26 2023-12-01 中国医学科学院基础医学研究所 Modified human papilloma virus 52 type L1 protein and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000054730A2 (en) 1999-03-18 2000-09-21 The President & Fellows Of Harvard College Compositions preparations and uses of human papillomavirus l1 protein
CN1293093C (en) 2002-08-30 2007-01-03 马润林 Pronucleus preparation of nipple tumour virus capsid protein and application
TWI349036B (en) * 2004-03-24 2011-09-21 Merck Sharp & Dohme Optimized expression of hpv 52 l1 in yeast
CN101153280B (en) * 2006-09-29 2015-08-19 厦门大学 The method of purifying human papilloma virus advanced protein L1 from prokaryotic organism
BRPI0811016B1 (en) 2007-04-29 2021-09-21 Xiamen Innovax Biotech Co., Ltd. LI TRUNCATE PROTEIN FROM HUMAN PAPILOMA VIRUS TYPE 16
WO2008134935A1 (en) * 2007-04-29 2008-11-13 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated human papillomavirus type 18 l1 proteins
EP2154148B1 (en) * 2007-05-29 2016-06-22 Xiamen University A truncated l1 protein of human papillomavirus 11
BRPI0810951B8 (en) * 2007-05-29 2021-05-25 Beijing Wantai Biological Pharmacy Entpr Co Ltd hpv6 l1 protein, polynucleotide, vector, cell, virus-like particle (vlp) hpv6, method for producing truncated hpv6 l1 protein, vaccine for prevention of condyloma acuminatum or hpv infections, use of truncated hpv6 l1 protein, method for prevention of condyloma acuminata or hpv infections, method of obtaining a vlp of a hpv6 l1 protein, and method of producing a vaccine for the prevention of condyloma acuminatum or hpv infections

Also Published As

Publication number Publication date
BR112013000031A2 (en) 2016-05-10
EP2589604B1 (en) 2016-10-05
WO2012000454A1 (en) 2012-01-05
CN102268076A (en) 2011-12-07
US20130230548A1 (en) 2013-09-05
CN102268076B (en) 2017-04-26
EP2589604A1 (en) 2013-05-08
EP2589604A4 (en) 2013-12-18
DK2589604T3 (en) 2017-01-16
US9499591B2 (en) 2016-11-22

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