IN2013CN00308A - - Google Patents

Info

Publication number
IN2013CN00308A
IN2013CN00308A IN308CHN2013A IN2013CN00308A IN 2013CN00308 A IN2013CN00308 A IN 2013CN00308A IN 308CHN2013 A IN308CHN2013 A IN 308CHN2013A IN 2013CN00308 A IN2013CN00308 A IN 2013CN00308A
Authority
IN
India
Prior art keywords
clusters
fluid
frequency
magnetic field
particles
Prior art date
Application number
Inventor
Andrea Ranzoni
Menno Willem Jose Prins
Original Assignee
Koninkl Philips Electronics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv filed Critical Koninkl Philips Electronics Nv
Publication of IN2013CN00308A publication Critical patent/IN2013CN00308A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule

Abstract

A method for detecting clusters of superparamagnetic particles coated with a bioreactive agent is provided. A suspension of the superparamagneticparticles in a fluid to be analyzed is provided. The particles are allowed to form clusters due to an analyte present within the fluid and a magnetic field rotating at a given frequency is applied to the solution. Light is directed to the fluid and the amplitude ofthe intensity of scattered light at twice the frequencyofthe magnetic field is extracted. By determining the amplitude of the measured intensityofscattered light at twice the field depending on the frequency of the magnetic field a frequency dependent measurement may be achieved. The frequency dependent measurement may be used to determine the critical frequency of clusters to distinguish clusters having different sizes or to measure the average value of the susceptibility and the spread of the susceptibility of the particles in the fluid. Furthermore an apparatus for apparatus for detecting clusters of superparamagnetic particles is provided.
IN308CHN2013 2010-07-02 2011-05-25 IN2013CN00308A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10168221 2010-07-02
EP11158688 2011-03-17
PCT/IB2011/052265 WO2012001546A1 (en) 2010-07-02 2011-05-25 Detection of actuated clusters by scattering

Publications (1)

Publication Number Publication Date
IN2013CN00308A true IN2013CN00308A (en) 2015-07-03

Family

ID=44303397

Family Applications (1)

Application Number Title Priority Date Filing Date
IN308CHN2013 IN2013CN00308A (en) 2010-07-02 2011-05-25

Country Status (5)

Country Link
EP (1) EP2588861A1 (en)
CN (1) CN103097894A (en)
BR (1) BR112012033586A8 (en)
IN (1) IN2013CN00308A (en)
WO (1) WO2012001546A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004530103A (en) * 2000-10-20 2004-09-30 ビナックス インコーポレーティッド Methods for detecting or quantifying biological reactions using superparamagnetic labels
AU2002317095A1 (en) * 2001-07-03 2003-01-21 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
US9658219B2 (en) * 2006-12-12 2017-05-23 Koninklijke Philips N.V. Microelectronic sensor device for detecting label particles
CN102144162B (en) * 2008-09-05 2017-11-10 皇家飞利浦电子股份有限公司 Rotating excitation field is to improve the detection in cluster analysis

Also Published As

Publication number Publication date
CN103097894A (en) 2013-05-08
EP2588861A1 (en) 2013-05-08
BR112012033586A8 (en) 2016-09-20
WO2012001546A1 (en) 2012-01-05
BR112012033586A2 (en) 2016-08-16

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