IN2012DN05163A - - Google Patents

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Publication number
IN2012DN05163A
IN2012DN05163A IN5163DEN2012A IN2012DN05163A IN 2012DN05163 A IN2012DN05163 A IN 2012DN05163A IN 5163DEN2012 A IN5163DEN2012 A IN 5163DEN2012A IN 2012DN05163 A IN2012DN05163 A IN 2012DN05163A
Authority
IN
India
Prior art keywords
vaccine
composition
endosialin
edb
tenascin
Prior art date
Application number
Inventor
Anna-Karin Olsson
Lars Hellman
Original Assignee
Theravac Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravac Pharmaceuticals Ab filed Critical Theravac Pharmaceuticals Ab
Publication of IN2012DN05163A publication Critical patent/IN2012DN05163A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a composition for the treatment of various cancers. The composition is a vaccine containing sequences of EDB, EDA, annexin Al, endosialin, C domain of tenascin C or magic roundabout (MR) or fragments thereof as single or in a combination coupled to one or several heterologous foreign carrier molecules. The vaccine will produce antibodies that are directed against self proteins which are preferentially expressed in and around tumor vessels. The vaccine is preferably administrated together with an adjuvant.
IN5163DEN2012 2009-12-15 2010-12-15 IN2012DN05163A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0901565A SE535982C2 (en) 2009-12-15 2009-12-15 A new vaccine that attacks tumor vessels as an effective tool in tumor therapy
PCT/SE2010/000300 WO2011075035A1 (en) 2009-12-15 2010-12-15 A novel vaccine that targets tumor vessels as an efficient tool in tumor therapy

Publications (1)

Publication Number Publication Date
IN2012DN05163A true IN2012DN05163A (en) 2015-10-23

Family

ID=44167552

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5163DEN2012 IN2012DN05163A (en) 2009-12-15 2010-12-15

Country Status (10)

Country Link
US (1) US20130122028A1 (en)
EP (1) EP2512510A4 (en)
JP (1) JP2013513659A (en)
CN (1) CN102791290A (en)
AU (1) AU2010332327A1 (en)
CA (1) CA2783969A1 (en)
IN (1) IN2012DN05163A (en)
RU (1) RU2012124261A (en)
SE (1) SE535982C2 (en)
WO (1) WO2011075035A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104277102B (en) * 2014-06-27 2017-04-12 李光辉 Amino acid sequence for detecting breast cancer marker Annexin Al antigen epitope and application of amino acid sequence
CN107903307B (en) * 2017-10-17 2020-12-18 北京大学 High-affinity EDB-FN protein targeting peptide and application thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992017604A1 (en) * 1991-03-26 1992-10-15 Otsuka Pharmaceutical Factory, Inc. Anti-eda monoclonal antibody
US5342757A (en) * 1992-11-13 1994-08-30 Ludwig Institute For Cancer Research Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
DK96493D0 (en) * 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps PROCEDURE FOR INDUCING ANTIBODY RESPONSE TO SELF-PROTEINS AND AUTOVACCINE PROCESSED BY THE PROCEDURE
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
EP1752160A3 (en) * 2001-04-06 2007-05-30 Mannkind Corporation Epitope sequences
JP4869603B2 (en) * 2002-11-20 2012-02-08 キャンサー・リサーチ・テクノロジー・リミテッド Antibodies, polypeptides and uses thereof
TWI445525B (en) * 2004-06-02 2014-07-21 Sidney Kimmel Cancer Ct Use of vascular targets for detecting, imaging and treating neoplasia or neovasculature
AU2005321898B2 (en) * 2004-12-29 2012-07-19 Mannkind Corporation Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines
GB0508726D0 (en) * 2005-04-29 2005-06-08 Bioinvent Int Ab Polypeptide, vaccine and use thereof
US20060286074A1 (en) * 2005-05-31 2006-12-21 Yucheng Tang Methods for immunotherapy of cancer
ES2291071B1 (en) * 2005-06-13 2009-03-16 Proyecto De Biomedicina Cima, S.L. AGENTS AND METHODS BASED ON THE USE OF THE EDA DOMAIN OF FIBRONECTINE.
ZA200803759B (en) * 2005-11-02 2009-10-28 Univ Duke Concurrent chemotherapy and immunotherapy
ES2536465T3 (en) * 2008-10-01 2015-05-25 Immatics Biotechnologies Gmbh Composition of tumor-associated and cancer-related peptides for the treatment of glioblastoma (GBM) and other cancers

Also Published As

Publication number Publication date
SE535982C2 (en) 2013-03-19
WO2011075035A1 (en) 2011-06-23
RU2012124261A (en) 2014-01-27
JP2013513659A (en) 2013-04-22
SE0901565A1 (en) 2011-06-16
AU2010332327A2 (en) 2012-07-12
EP2512510A4 (en) 2014-02-26
CN102791290A (en) 2012-11-21
US20130122028A1 (en) 2013-05-16
EP2512510A1 (en) 2012-10-24
AU2010332327A1 (en) 2012-07-05
CA2783969A1 (en) 2011-06-23

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