IN2012DN05054A - - Google Patents
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- Publication number
- IN2012DN05054A IN2012DN05054A IN5054DEN2012A IN2012DN05054A IN 2012DN05054 A IN2012DN05054 A IN 2012DN05054A IN 5054DEN2012 A IN5054DEN2012 A IN 5054DEN2012A IN 2012DN05054 A IN2012DN05054 A IN 2012DN05054A
- Authority
- IN
- India
- Prior art keywords
- megakaryocytes
- differentiation
- platelets
- hescs
- stromal
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2311—Interleukin-11 (IL-11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1394—Bone marrow stromal cells; whole marrow
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26693909P | 2009-12-04 | 2009-12-04 | |
| US38416510P | 2010-09-17 | 2010-09-17 | |
| PCT/US2010/058990 WO2011069127A1 (fr) | 2009-12-04 | 2010-12-03 | Production à grande échelle de plaquettes et de mégacaryocytes fonctionnels provenant de cellules souches embryonnaires humaines, dans des conditions exemptes de stroma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN05054A true IN2012DN05054A (fr) | 2015-10-09 |
Family
ID=44115332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN5054DEN2012 IN2012DN05054A (fr) | 2009-12-04 | 2010-12-03 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9988603B2 (fr) |
| EP (1) | EP2507359A4 (fr) |
| JP (4) | JP2013512676A (fr) |
| KR (4) | KR20190142424A (fr) |
| AU (4) | AU2010325811A1 (fr) |
| BR (1) | BR112012013497A2 (fr) |
| CA (2) | CA3115233A1 (fr) |
| IN (1) | IN2012DN05054A (fr) |
| RU (1) | RU2012127810A (fr) |
| WO (1) | WO2011069127A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2377923A1 (fr) | 2006-04-14 | 2011-10-19 | Advanced Cell Technology, Inc. | Cellules formant colonie d'hemangio |
| AU2010325811A1 (en) | 2009-12-04 | 2012-06-21 | Stem Cell & Regenerative Medicine International, Inc. | Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions |
| CA2857545A1 (fr) | 2011-11-30 | 2013-06-06 | Advanced Cell Technology, Inc. | Cellules stromales mesenchymateuses et utilisation s'y rapportant |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| CA2896053A1 (fr) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees |
| JP6580329B2 (ja) | 2014-03-31 | 2019-09-25 | シスメックス株式会社 | 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法 |
| US10538738B2 (en) | 2014-05-19 | 2020-01-21 | Eleftherios Papoutsakis | Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells |
| US20180030475A1 (en) * | 2015-03-30 | 2018-02-01 | Jeffrey Thomas Loh | Methods for producing modified red blood cell compositions, compositions and uses thereof |
| IL299326A (en) | 2015-08-18 | 2023-02-01 | Astellas Inst For Regenerative Medicine | Clinical formulations |
| SG11201802159UA (en) * | 2015-10-14 | 2018-04-27 | Megakaryon Corp | Method for producing purified platelets |
| BR112020013656A2 (pt) | 2018-01-05 | 2020-12-01 | Platelet Biogenesis, Inc. | composições e métodos para produção de megacariócitos |
| CN115768877A (zh) | 2020-05-11 | 2023-03-07 | 斯特姆生物公司 | 与巨核细胞来源的细胞外囊泡相关的组合物和方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128259A (en) | 1989-10-27 | 1992-07-07 | Hahnemann University | Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation |
| CA2437084C (fr) | 2001-01-29 | 2010-12-21 | Ivan N. Rich | Dosage a haut rendement de cellules souches d'une souche hematopoietique et proliferation de cellules progenitrices |
| WO2002078449A2 (fr) | 2001-04-02 | 2002-10-10 | Advanced Cell Technology, Inc. | Procede permettant de faciliter la production de types de cellules et de tissus differencies a partir de cellules pluripotentes et multipotentes embryonnaires et adultes |
| US20030232430A1 (en) | 2001-11-26 | 2003-12-18 | Advanced Cell Technology | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| US20040052771A1 (en) | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| CN1286970C (zh) | 2003-12-30 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 由脐血cd34+细胞体外诱导生成巨核细胞的方法 |
| US20050221482A1 (en) | 2004-03-31 | 2005-10-06 | Burt Richard K | Methods and compositions for obtaining hematopoietic stem cells derived from embryonic stem cells and uses thereof |
| AU2005302258B2 (en) * | 2004-11-01 | 2010-10-21 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| AU2007215276B2 (en) | 2006-02-09 | 2013-09-19 | Maryna E. Gumenyuk | Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells |
| CN101045914A (zh) | 2006-03-29 | 2007-10-03 | 中国人民解放军军事医学科学院野战输血研究所 | 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用 |
| EP2377923A1 (fr) * | 2006-04-14 | 2011-10-19 | Advanced Cell Technology, Inc. | Cellules formant colonie d'hemangio |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| CN102083960B (zh) | 2008-05-06 | 2014-12-03 | 先进细胞技术公司 | 用于制备衍生自多能干细胞的去核类红细胞的方法 |
| KR20110016913A (ko) | 2008-05-06 | 2011-02-18 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 혈관 콜로니 형성 세포 및 비-생착성 혈관 세포 |
| AU2010325811A1 (en) | 2009-12-04 | 2012-06-21 | Stem Cell & Regenerative Medicine International, Inc. | Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions |
-
2010
- 2010-12-03 AU AU2010325811A patent/AU2010325811A1/en not_active Abandoned
- 2010-12-03 KR KR1020197037186A patent/KR20190142424A/ko not_active IP Right Cessation
- 2010-12-03 KR KR1020187021160A patent/KR20180086301A/ko active Application Filing
- 2010-12-03 CA CA3115233A patent/CA3115233A1/fr not_active Abandoned
- 2010-12-03 CA CA2782013A patent/CA2782013C/fr active Active
- 2010-12-03 WO PCT/US2010/058990 patent/WO2011069127A1/fr active Application Filing
- 2010-12-03 EP EP10835231.1A patent/EP2507359A4/fr not_active Withdrawn
- 2010-12-03 IN IN5054DEN2012 patent/IN2012DN05054A/en unknown
- 2010-12-03 KR KR1020217016080A patent/KR20210066020A/ko not_active Application Discontinuation
- 2010-12-03 US US13/512,827 patent/US9988603B2/en active Active
- 2010-12-03 RU RU2012127810/10A patent/RU2012127810A/ru not_active Application Discontinuation
- 2010-12-03 JP JP2012542230A patent/JP2013512676A/ja active Pending
- 2010-12-03 KR KR1020127017368A patent/KR20120128605A/ko active Application Filing
- 2010-12-03 BR BR112012013497A patent/BR112012013497A2/pt not_active Application Discontinuation
-
2016
- 2016-04-25 JP JP2016086761A patent/JP2016135138A/ja active Pending
-
2017
- 2017-03-24 AU AU2017201995A patent/AU2017201995B2/en not_active Ceased
-
2018
- 2018-05-01 US US15/968,591 patent/US20190002829A1/en not_active Abandoned
-
2019
- 2019-03-05 JP JP2019039160A patent/JP2019122385A/ja active Pending
- 2019-05-24 AU AU2019203670A patent/AU2019203670B2/en not_active Ceased
-
2022
- 2022-01-13 AU AU2022200188A patent/AU2022200188A1/en not_active Abandoned
- 2022-01-28 JP JP2022011675A patent/JP2022064953A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012127810A (ru) | 2014-01-10 |
| KR20190142424A (ko) | 2019-12-26 |
| US20190002829A1 (en) | 2019-01-03 |
| JP2022064953A (ja) | 2022-04-26 |
| JP2013512676A (ja) | 2013-04-18 |
| CA2782013C (fr) | 2021-06-08 |
| JP2016135138A (ja) | 2016-07-28 |
| CA3115233A1 (fr) | 2011-06-09 |
| JP2019122385A (ja) | 2019-07-25 |
| CA2782013A1 (fr) | 2011-06-09 |
| AU2017201995A1 (en) | 2017-04-13 |
| US9988603B2 (en) | 2018-06-05 |
| KR20210066020A (ko) | 2021-06-04 |
| AU2019203670A1 (en) | 2019-06-13 |
| KR20120128605A (ko) | 2012-11-27 |
| KR20180086301A (ko) | 2018-07-30 |
| EP2507359A4 (fr) | 2015-05-13 |
| US20120315338A1 (en) | 2012-12-13 |
| AU2017201995B2 (en) | 2019-06-06 |
| AU2022200188A1 (en) | 2022-02-10 |
| WO2011069127A1 (fr) | 2011-06-09 |
| AU2010325811A1 (en) | 2012-06-21 |
| EP2507359A1 (fr) | 2012-10-10 |
| AU2019203670B2 (en) | 2021-10-14 |
| BR112012013497A2 (pt) | 2016-05-31 |
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