IN2012DN04939AIN4939DEN2012AIN2012DN04939AIN 2012DN04939 AIN2012DN04939 AIN 2012DN04939AIN 4939DEN2012 AIN4939DEN2012 AIN 4939DEN2012AIN 2012DN04939 AIN2012DN04939 AIN 2012DN04939A
Authority
IN
India
Prior art keywords
drug
core
skin
polymer
skins
Prior art date
Application number
Inventor
Kang-Jye Chou
Hong Guo
Paul Ashton
Robert W Shimizu
David A Watson
Original Assignee
Psivida Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psivida IncfiledCriticalPsivida Inc
Priority claimed from PCT/US2004/035430external-prioritypatent/WO2005051234A2/en
Publication of IN2012DN04939ApublicationCriticalpatent/IN2012DN04939A/en
An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as 'coatings,' 'skins,' or 'outer layers'). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.