IN2012DN02807A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02807A IN2012DN02807A IN2807DEN2012A IN2012DN02807A IN 2012DN02807 A IN2012DN02807 A IN 2012DN02807A IN 2807DEN2012 A IN2807DEN2012 A IN 2807DEN2012A IN 2012DN02807 A IN2012DN02807 A IN 2012DN02807A
- Authority
- IN
- India
- Prior art keywords
- compounds
- diseases
- hsd
- dyslipidemia
- obesity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
The present invention relates to compounds defined by formula I, wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 ß-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09175233 | 2009-11-06 | ||
PCT/US2010/055586 WO2011057054A1 (en) | 2009-11-06 | 2010-11-05 | Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN02807A true IN2012DN02807A (en) | 2015-07-24 |
Family
ID=41683136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2807DEN2012 IN2012DN02807A (en) | 2009-11-06 | 2010-11-05 |
Country Status (27)
Country | Link |
---|---|
US (3) | US8497281B2 (en) |
EP (1) | EP2496559B1 (en) |
JP (1) | JP5796015B2 (en) |
KR (1) | KR20120102688A (en) |
CN (2) | CN102666491B (en) |
AP (1) | AP2012006248A0 (en) |
AR (1) | AR078887A1 (en) |
AU (1) | AU2010315077B2 (en) |
BR (1) | BR112012010792A2 (en) |
CA (1) | CA2778161A1 (en) |
CL (1) | CL2012001043A1 (en) |
CO (1) | CO6531441A2 (en) |
EA (1) | EA022323B1 (en) |
GE (1) | GEP20156330B (en) |
HK (1) | HK1175470A1 (en) |
IL (1) | IL218652A0 (en) |
IN (1) | IN2012DN02807A (en) |
MA (1) | MA33776B1 (en) |
MX (1) | MX2012005309A (en) |
MY (1) | MY159922A (en) |
NZ (1) | NZ598950A (en) |
PE (1) | PE20121182A1 (en) |
SG (1) | SG179569A1 (en) |
TW (1) | TWI531571B (en) |
UA (1) | UA109643C2 (en) |
UY (1) | UY33001A (en) |
WO (1) | WO2011057054A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8329897B2 (en) | 2007-07-26 | 2012-12-11 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
AR069207A1 (en) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
TW200927115A (en) * | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2245014B1 (en) * | 2008-02-12 | 2011-11-02 | Boehringer Ingelheim International GmbH | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
EP2254872A2 (en) | 2008-02-15 | 2010-12-01 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
KR20110002492A (en) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW200950780A (en) | 2008-05-13 | 2009-12-16 | Boehringer Ingelheim Int | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
AU2009274567B2 (en) | 2008-07-25 | 2013-04-04 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
JP5544366B2 (en) | 2008-10-23 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Urea derivative of substituted nortropane, medicament containing the compound and use thereof |
EP2393807B1 (en) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1 |
UA109255C2 (en) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
WO2010139673A1 (en) | 2009-06-02 | 2010-12-09 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
TWI531571B (en) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
JP5813106B2 (en) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Azaspirohexanone as an inhibitor of 11-β-HSD1 for the treatment of metabolic disorders |
CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
TWI537258B (en) * | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
JP2014524438A (en) * | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Indenopyridine derivatives |
US20130303446A1 (en) * | 2012-05-09 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
JO3407B1 (en) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | Tetrahydropyrazolopyrimidine Compounds |
WO2015077286A1 (en) | 2013-11-20 | 2015-05-28 | Boehringer Ingelheim International Gmbh | Hexahydroindenopyridine derivatives |
CN109045035B (en) * | 2018-07-19 | 2020-07-28 | 广西科技大学 | Application of 7- (2, 2-dimethyl-3-butenamido) -octahydro phenylquinoline acetate in preparation of medicine for treating liver diseases |
AR127706A1 (en) * | 2021-11-19 | 2024-02-21 | Hoffmann La Roche | SYNTHESIS OF 2-(7,7-DIMETHYL-1H,7H-SPIRO[FURO[3,4-B]PYRIDIN-5,4-PIPERIDIN]-1-IL)-1,3-DIHYDRO- 4H-SPYRO[INDEN-2,5-[1,3]OXAZOLE]-4-ONE |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127995C (en) | 1963-12-20 | Geigy Ag J R | ||
US3341538A (en) | 1965-06-18 | 1967-09-12 | Geigy Chem Corp | Certain 2, 6-methano-3-benzazocines |
DE1785124A1 (en) | 1968-08-13 | 1971-11-11 | Prym Werke William | Zipper |
DE2108954A1 (en) | 1971-02-25 | 1972-09-07 | Boehringer Sohn Ingelheim | 2-(furylmethyl)-6,7-benzomorphans - useful as cns active agents |
GB1304175A (en) | 1969-03-31 | 1973-01-24 | ||
DE2105743C3 (en) | 1971-02-08 | 1979-11-29 | Boehringer Sohn Ingelheim | 2- (Furylmethyl) - a -5,9-dialkyl -6,7benzomorphane, process for their preparation and their use |
US3681349A (en) | 1970-03-05 | 1972-08-01 | Morton Norwich Products Inc | 1-(substituted benzyl) tetrahydro-2-(1h) pyrimidones |
US3657257A (en) | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryl-8-carbamoyl nortropanes |
DE2229695A1 (en) | 1972-06-19 | 1974-01-31 | Boehringer Sohn Ingelheim | 2- (HETEROARYL-METHYL) -5,9 BETA-DIALKYL6,7-BENZOMORPHANES, THEIR ACID ADDITIONAL SALTS AND THE PROCESS FOR THEIR PRODUCTION |
DE2338369A1 (en) | 1973-07-26 | 1975-02-13 | Schering Ag | MICROBIOLOGICAL HYDROXYLATION OF 2,6-METHANO-3-BENZAZOCINES |
SU510999A3 (en) | 1973-10-27 | 1976-04-15 | К.Х.Берингер Зон, (Фирма) | Method for producing (methoxymethyl-furylmethyl) 6,7-benzomorphanes of morphinanes |
US4009171A (en) | 1974-02-21 | 1977-02-22 | Sterling Drug Inc. | N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates |
DE2411382C3 (en) | 1974-03-09 | 1979-09-06 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-Tetrahydrofurfuryl-6,7-benzomorphane, process for the preparation and their use |
US4087532A (en) | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
DE2437610A1 (en) | 1974-08-05 | 1976-02-26 | Boehringer Sohn Ingelheim | NEW 5.9-BETA-DISUBSTITUTED 2-TETRAHYDROFURFURYL-6,7-BENZOMORPHANES, THEIR ACID-ADDITIONAL SALTS, THEIR USE AS A MEDICINAL PRODUCTS AND METHOD FOR THEIR PRODUCTION |
US4108857A (en) | 1975-08-18 | 1978-08-22 | Sterling Drug Inc. | Imidazolylmethyl methanobenzazocines |
DE2828039A1 (en) | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF |
GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
GB9517622D0 (en) | 1995-08-29 | 1995-11-01 | Univ Edinburgh | Regulation of intracellular glucocorticoid concentrations |
US6251897B1 (en) | 1996-07-31 | 2001-06-26 | Nikken Chemicals Co., Ltd | 6-phenyltetrahydro-1,3-oxazin-2-one derivative and pharmaceutical composition containing the same |
GB9623944D0 (en) | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
WO1998052879A1 (en) | 1997-05-20 | 1998-11-26 | Heraeus Quarzglas Gmbh | Synthetic silica glass used with uv-rays and method producing the same |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
YU54202A (en) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation |
WO2001055063A1 (en) | 2000-01-25 | 2001-08-02 | Idemitsu Petrochemical Co., Ltd. | Novel bisadamantane compounds, process for preparing the same, and novel biadamantane derivatives |
DE10034623A1 (en) | 2000-07-17 | 2002-01-31 | Bayer Ag | New heterocyclic substituted pyridine derivatives useful as tumor necrosis factor-alpha inhibitors in treatment of e.g. atherosclerosis, arthritis, Crohn's disease, osteoporosis, transplant rejection and psoriasis |
MXPA04011327A (en) | 2002-05-17 | 2005-08-15 | Jenken Biosciences Inc | Opioid and opioid-like compounds and uses thereof. |
WO2004087159A1 (en) | 2003-03-26 | 2004-10-14 | Merck & Co., Inc. | Bicyclic piperidine derivatives as melanocortin-4 receptor agonists |
EP1862181A3 (en) * | 2003-04-11 | 2010-09-15 | High Point Pharmaceuticals, LLC | New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof |
EP1615698B1 (en) | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
US7700583B2 (en) | 2003-04-11 | 2010-04-20 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
CN1980889B (en) | 2004-05-07 | 2010-11-10 | 詹森药业有限公司 | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
UA89043C2 (en) * | 2004-05-07 | 2009-12-25 | Инсайт Корпорейшн | Amido compounds and their use as pharmaceuticals |
ATE445600T1 (en) * | 2004-08-30 | 2009-10-15 | Janssen Pharmaceutica Nv | DERIVATIVES OF TRICYCLIC LACTAM AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS |
JP2008515956A (en) | 2004-10-12 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | 11.beta.-hydroxysteroid dehydrogenase type 1 active spiro compound |
EP1809626A2 (en) | 2004-10-13 | 2007-07-25 | Neurogen Corporation | Aryl substituted 8-azabicyclo[3.2.1]octane compounds as ligands of the melanin concentrating hormone receptor |
EP1864971A4 (en) | 2005-03-31 | 2010-02-10 | Takeda Pharmaceutical | Prophylactic/therapeutic agent for diabetes |
CA2602781C (en) * | 2005-04-05 | 2011-02-08 | F. Hoffmann-La Roche Ag | 1h-pyrazole 4-carboxylamides, their preparation and their use as 11beta-hydroxysteroid dehydrogenase |
US8053431B2 (en) | 2005-11-01 | 2011-11-08 | High Point Pharmaceuticals, Llc | Pharmaceutical use of substituted amides |
CA2627306A1 (en) | 2005-11-01 | 2007-05-10 | Transtech Pharma, Inc. | Pharmaceutical use of substituted amides |
JP2007140188A (en) | 2005-11-18 | 2007-06-07 | Fujifilm Corp | Positive photosensitive composition and pattern forming method using the same |
WO2007076055A2 (en) | 2005-12-22 | 2007-07-05 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
CA2635087A1 (en) | 2005-12-30 | 2007-07-19 | Merck & Co., Inc. | Cholesteryl ester transfer protein inhibitors |
TW200804341A (en) | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
JP5265521B2 (en) | 2006-04-21 | 2013-08-14 | イーライ リリー アンド カンパニー | Biphenylamide lactam derivatives as 11-β-hydroxysteroid dehydrogenase 1 inhibitors |
ES2346925T3 (en) | 2006-04-24 | 2010-10-21 | ELI LILLY & COMPANY | PIRROLIDINONES REPLACED AS INHIBITORS OF THE 11 BETA-DIHYDROESTEROID DEHYDROGENASE 1. |
CA2648019C (en) | 2006-04-25 | 2014-04-01 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
PE20080344A1 (en) | 2006-06-27 | 2008-06-09 | Sanofi Aventis | 8-AZABICYCLE COMPOUNDS [3.2.1] OCT-8-IL-1,2,3,4-TETRAHYDROQUINOLINE SUBSTITUTED AS INHIBITORS 11B-HSD1 |
KR101118410B1 (en) | 2006-10-19 | 2012-04-23 | 에프. 호프만-라 로슈 아게 | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
TW200829171A (en) | 2006-11-17 | 2008-07-16 | Nihon Nohyaku Co Ltd | Haloalkyl sulfonanilide derivatives or salts thereof, herbicide using it as effective constituent and use-method thereof |
EP1935420A1 (en) | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
RU64276U1 (en) | 2007-03-01 | 2007-06-27 | Открытое акционерное общество "Татнефть" им. В.Д. Шашина | PIPE LINING OF THE ORIENTAL FITTING OF THE EXPLOSIVE WELL |
JP2010520864A (en) | 2007-03-09 | 2010-06-17 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | Indole- and benzimidazolamides as hydroxysteroid dehydrogenase inhibitors |
US8329897B2 (en) | 2007-07-26 | 2012-12-11 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
AR069207A1 (en) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
TW200927115A (en) * | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
WO2009102428A2 (en) | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
EP2245014B1 (en) * | 2008-02-12 | 2011-11-02 | Boehringer Ingelheim International GmbH | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
EP2254872A2 (en) | 2008-02-15 | 2010-12-01 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
US20110105504A1 (en) | 2008-03-18 | 2011-05-05 | Vitae Pharmaceuticals ,Inc. | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 |
WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
KR20110002492A (en) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
AU2009274567B2 (en) | 2008-07-25 | 2013-04-04 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
UA109255C2 (en) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TWI531571B (en) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
-
2010
- 2010-11-04 TW TW099137926A patent/TWI531571B/en not_active IP Right Cessation
- 2010-11-04 UY UY0001033001A patent/UY33001A/en not_active Application Discontinuation
- 2010-11-04 AR ARP100104083A patent/AR078887A1/en unknown
- 2010-11-05 CN CN201080050242.1A patent/CN102666491B/en not_active Expired - Fee Related
- 2010-11-05 MX MX2012005309A patent/MX2012005309A/en active IP Right Grant
- 2010-11-05 WO PCT/US2010/055586 patent/WO2011057054A1/en active Application Filing
- 2010-11-05 IN IN2807DEN2012 patent/IN2012DN02807A/en unknown
- 2010-11-05 BR BR112012010792A patent/BR112012010792A2/en not_active IP Right Cessation
- 2010-11-05 EA EA201270562A patent/EA022323B1/en not_active IP Right Cessation
- 2010-11-05 GE GEAP201012734A patent/GEP20156330B/en unknown
- 2010-11-05 US US12/940,387 patent/US8497281B2/en active Active
- 2010-11-05 SG SG2012019006A patent/SG179569A1/en unknown
- 2010-11-05 MY MYPI2012001349A patent/MY159922A/en unknown
- 2010-11-05 NZ NZ598950A patent/NZ598950A/en not_active IP Right Cessation
- 2010-11-05 CA CA2778161A patent/CA2778161A1/en not_active Abandoned
- 2010-11-05 AP AP2012006248A patent/AP2012006248A0/en unknown
- 2010-11-05 AU AU2010315077A patent/AU2010315077B2/en not_active Ceased
- 2010-11-05 KR KR1020127014706A patent/KR20120102688A/en not_active Application Discontinuation
- 2010-11-05 UA UAA201206863A patent/UA109643C2/en unknown
- 2010-11-05 EP EP10782081.3A patent/EP2496559B1/en active Active
- 2010-11-05 JP JP2012538024A patent/JP5796015B2/en active Active
- 2010-11-05 PE PE2012000605A patent/PE20121182A1/en not_active Application Discontinuation
- 2010-11-05 CN CN201510296816.8A patent/CN105037326A/en active Pending
-
2012
- 2012-03-15 IL IL218652A patent/IL218652A0/en unknown
- 2012-04-13 CO CO12060938A patent/CO6531441A2/en active IP Right Grant
- 2012-04-24 CL CL2012001043A patent/CL2012001043A1/en unknown
- 2012-05-31 MA MA34913A patent/MA33776B1/en unknown
-
2013
- 2013-03-06 HK HK13102808.3A patent/HK1175470A1/en not_active IP Right Cessation
- 2013-06-20 US US13/922,889 patent/US9328072B2/en active Active
-
2016
- 2016-03-24 US US15/079,544 patent/US9663470B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2012DN02807A (en) | ||
TN2012000117A1 (en) | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline | |
WO2010046445A3 (en) | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use | |
WO2009100872A8 (en) | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use | |
WO2009063061A3 (en) | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use | |
WO2009138386A3 (en) | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use | |
MX2012002633A (en) | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes. | |
TN2011000201A1 (en) | Aminotetrahydropyrans as dipeptidyl peptidase - iv inhibitors for the treatment or prevention of diabetes | |
MX2009011753A (en) | Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme. | |
WO2008011131A3 (en) | Amide compounds | |
GEP20146169B (en) | N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors | |
EP2571876A4 (en) | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes | |
SG179034A1 (en) | 2 -aminodihydro [1, 3] thiazines as bace 2 inhibitors for the treatment of diabetes | |
WO2011014795A3 (en) | Compounds and compositions as syk kinase inhibitors | |
GEP20156309B (en) | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | |
MX2009011754A (en) | Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme. | |
JO2732B1 (en) | Organic Compounds | |
TN2012000578A1 (en) | Tetrahydro-pyrido-pyrimidine derivatives | |
DE502005010342D1 (en) | Substituierte cyclohexylessigsäure-derivate | |
MY173696A (en) | Cyclic amide derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase and uses thereof | |
TN2012000418A1 (en) | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation | |
IN2012DN03846A (en) | ||
MX340804B (en) | Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1. | |
MX2014003883A (en) | Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders. | |
TW200745059A (en) | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |