IN2012DN02493A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02493A
IN2012DN02493A IN2493DEN2012A IN2012DN02493A IN 2012DN02493 A IN2012DN02493 A IN 2012DN02493A IN 2493DEN2012 A IN2493DEN2012 A IN 2493DEN2012A IN 2012DN02493 A IN2012DN02493 A IN 2012DN02493A
Authority
IN
India
Prior art keywords
present
tyrosine kinase
compounds
diseases
prevention
Prior art date
Application number
Inventor
Guo Xialing
Zhu Zhen
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43086186&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN02493(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of IN2012DN02493A publication Critical patent/IN2012DN02493A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.
IN2493DEN2012 2009-09-03 2010-09-03 IN2012DN02493A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23960309P 2009-09-03 2009-09-03
US30661610P 2010-02-22 2010-02-22
US35669910P 2010-06-21 2010-06-21
US36053110P 2010-07-01 2010-07-01
PCT/US2010/047800 WO2011028995A1 (en) 2009-09-03 2010-09-03 Compounds as tyrosine kinase modulators

Publications (1)

Publication Number Publication Date
IN2012DN02493A true IN2012DN02493A (en) 2015-08-28

Family

ID=43086186

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2493DEN2012 IN2012DN02493A (en) 2009-09-03 2010-09-03

Country Status (19)

Country Link
US (5) US8614234B2 (en)
EP (2) EP2473513B1 (en)
JP (3) JP2013503903A (en)
KR (2) KR20120082890A (en)
CN (2) CN102686577A (en)
AU (2) AU2010289353B2 (en)
BR (2) BR112012004843A2 (en)
CA (2) CA2772718C (en)
CL (2) CL2012000587A1 (en)
ES (1) ES2730086T3 (en)
IL (2) IL218332A0 (en)
IN (1) IN2012DN02493A (en)
MX (2) MX2012002596A (en)
NZ (2) NZ598781A (en)
PH (1) PH12014500281A1 (en)
RU (2) RU2012109233A (en)
SG (2) SG178963A1 (en)
WO (2) WO2011029001A1 (en)
ZA (2) ZA201201592B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
EP2297133B1 (en) * 2008-06-25 2017-09-13 Forum Pharmaceuticals Inc. 1, 2 disubstituted heterocyclic compounds
US8293897B2 (en) 2008-10-14 2012-10-23 Ning Xi Compounds comprising a spiro-ring and methods of use
CA2752421C (en) 2009-03-21 2013-08-06 Ning Xi Amino ester derivatives, salts thereof and methods of use
HUE026238T2 (en) * 2009-05-07 2016-06-28 Forum Pharmaceuticals Inc Phenoxymethyl heterocyclic compounds
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US8906944B2 (en) * 2009-09-03 2014-12-09 Allergan, Inc. Compounds as tyrosine kinase modulators
MX2012002596A (en) * 2009-09-03 2012-07-03 Allergan Inc Compounds as tyrosine kinase modulators.
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
BR112014017762A8 (en) * 2012-02-09 2017-07-11 Merck Patent Gmbh FURO[3,2-B]- AND THIENO[3,2-B]PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS, THEIR USES, PROCESS FOR PREPARING THEM AND DRUGS INCLUDING THEM
WO2015069287A1 (en) * 2013-11-08 2015-05-14 Allergan, Inc. Compounds as tyrosine kinase modulators
WO2015089479A1 (en) * 2013-12-13 2015-06-18 Dana-Farber Cancer Institute, Inc. Methods to treat lymphoplasmacytic lymphoma
EP3079682A4 (en) 2013-12-13 2017-08-30 Dana-Farber Cancer Institute, Inc. Methods to treat lymphoplasmacytic lymphoma
CN104974132B (en) * 2014-04-08 2017-05-17 北大方正集团有限公司 Polysubstituted pyridine compound and preparation method and application thereof as well as pharmaceutical composition
AU2015266850B2 (en) 2014-05-29 2019-12-05 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
CN113121450A (en) 2014-08-29 2021-07-16 Tes制药有限责任公司 Alpha-amino-beta-carboxymuconate semialdehyde decarboxylase inhibitors
CN104326985A (en) * 2014-09-24 2015-02-04 安润医药科技（苏州）有限公司 Preparation method of linifanib
CA2965178C (en) 2014-10-22 2023-09-26 Dana-Farber Cancer Institute, Inc. Thiazolyl-containing compounds for treating proliferative diseases
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017157332A1 (en) * 2016-03-18 2017-09-21 江苏恒瑞医药股份有限公司 Aromatic amide derivative, preparation method therefor, and pharmaceutical applications thereof
AU2017252294B2 (en) 2016-04-20 2021-12-02 Dose Medical Corporation Bioresorbable ocular drug delivery device
CN107663202B (en) * 2016-07-29 2020-09-04 西华大学 3- (ureido-methyl) -4-aryl-pyridine derivative, preparation method thereof and application thereof as anti-liver cancer drug
JP7086987B2 (en) 2017-03-21 2022-06-20 ザ スクリプス リサーチ インスティテュート Copper- and nickel-catalyzed decarboxylation reaction
EP3621960B1 (en) 2017-05-11 2021-08-04 Bristol-Myers Squibb Company Thienopyridines and benzothiophenes useful as irak4 inhibitors
JP2020520373A (en) * 2017-05-18 2020-07-09 ピーアイ インダストリーズ リミテッドＰｉ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ Formimide amidine compounds useful against phytopathogenic microorganisms
EP3860998B1 (en) 2018-10-05 2023-12-27 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US4966849A (en) 1985-09-20 1990-10-30 President And Fellows Of Harvard College CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
US5217999A (en) 1987-12-24 1993-06-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Styryl compounds which inhibit EGF receptor protein tyrosine kinase
DE69105495T2 (en) 1990-04-02 1995-04-06 Pfizer BENZYLPHOSPHONIC ACID TYROSINKINAS INHIBITORS.
US5302606A (en) * 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
SG64322A1 (en) 1991-05-10 1999-04-27 Rhone Poulenc Rorer Int Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
JPH06503095A (en) 1991-05-29 1994-04-07 ファイザー・インコーポレーテッド Tricyclic polyhydroxy tyrosine kinase inhibitor
HUT71553A (en) 1992-08-06 1995-12-28 Warner Lambert Co 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties
US5330992A (en) 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
GB9226855D0 (en) 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU9802198A (en) * 1997-10-21 1999-05-10 Pharmacia & Upjohn Company Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors
ES2318649T3 (en) * 2000-10-20 2009-05-01 EISAI R&D MANAGEMENT CO., LTD. PROCEDURE FOR PREPARATION OF DERIVATIVES OF 4-FENOXI QUINOLINAS.
CN1518546A (en) 2001-05-08 2004-08-04 ���ֹɷݹ�˾ Selective anthranilamide pyridine amides as inhibitors of VEGRF-2 and VEGFR-3
WO2003027102A1 (en) * 2001-09-27 2003-04-03 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US6541504B1 (en) * 2002-04-03 2003-04-01 Allergan Sales, Llc (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
TWI319387B (en) * 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US20050058689A1 (en) 2003-07-03 2005-03-17 Reactive Surfaces, Ltd. Antifungal paints and coatings
US6747025B1 (en) * 2002-11-27 2004-06-08 Allergan, Inc. Kinase inhibitors for the treatment of disease
GB0229022D0 (en) * 2002-12-12 2003-01-15 Novartis Ag Organic Compounds
MXPA05009102A (en) * 2003-02-28 2006-05-31 Bayer Pharmaceuticals Corp Substituted pyridine derivatives useful in the treatment of cancer and other disorders.
CA2526617C (en) * 2003-05-20 2015-04-28 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
DE602004017479D1 (en) * 2003-08-29 2008-12-11 Pfizer THIENOPYRIDINPHENYLACETAMIDES SUITED AS NEW ANTIANGIOGENIC AGENTS AND DERIVATIVES THEREOF
CA2536788A1 (en) * 2003-08-29 2005-03-10 Pfizer Inc. Naphthalene carboxamides and their derivatives useful as new anti-angiogenic agents
WO2005110410A2 (en) * 2004-05-14 2005-11-24 Abbott Laboratories Kinase inhibitors as therapeutic agents
CA2589773A1 (en) * 2004-12-22 2006-06-29 Astrazeneca Ab Pyridine carboxamide derivatives for use as anticancer agents
TWI422376B (en) * 2005-01-25 2014-01-11 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
EP1846388A4 (en) * 2005-01-25 2011-12-07 Synta Pharmaceuticals Corp Thiophene compounds for inflammation and immune-related uses
CN101142194B (en) 2005-03-14 2012-10-10 顶点制药有限责任公司 Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
ES2473341T3 (en) * 2005-05-20 2014-07-04 Methylgene Inc Inhibitors of VEGF receptor and HGF receptor signaling
JP2008545756A (en) * 2005-06-03 2008-12-18 バイエル・ヘルスケア・アクチェンゲゼルシャフト 1-methyl-1H-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents
DE102005062742A1 (en) * 2005-12-22 2007-06-28 Bayer Schering Pharma Ag New sulfoximine-substituted pyrimidines useful for treating e.g. diseases caused by inflammatory, allergic or proliferative processes, oncological diseases, cancer, eye, autoimmune and neurodegerative diseases
WO2007076474A1 (en) * 2005-12-23 2007-07-05 Kalypsys, Inc. Novel substituted pyridinyloxy and pyrimidinyloxy amides useful as inhibitors of protein kinases
AR059246A1 (en) * 2006-01-30 2008-03-19 Array Biopharma Inc THIOPHENIC HETEROBICICLIC COMPOUNDS AND METHODS OF USE
CN101479255B (en) * 2006-03-22 2013-05-01 沃泰克斯药物股份有限公司 C-MET protein kinase inhibitors for the treatment of proliferative disorders
AR060061A1 (en) 2006-03-22 2008-05-21 Methylgene Inc INHIBITORS OF THE ACTIVITY OF PROTEIN TIROSINA QUINASA
US7790756B2 (en) * 2006-10-11 2010-09-07 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
EP2146717A4 (en) * 2007-04-20 2010-08-11 Deciphera Pharmaceuticals Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
MX2009011754A (en) * 2007-04-30 2009-12-01 Abbott Lab Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme.
EP2426108B1 (en) * 2007-08-29 2016-08-10 MethylGene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
AU2008293038B2 (en) 2007-08-29 2013-08-29 Mirati Therapeutics, Inc. Inhibitors of protein tyrosine kinase activity
US20090118276A1 (en) * 2007-11-02 2009-05-07 Wyeth Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors
WO2009070328A1 (en) 2007-11-26 2009-06-04 The Regents Of The University Of California Modulators of the epidermal growth factor receptor (egfr) pathway for use in the treatment or prevention of substance abuse
WO2009103778A1 (en) * 2008-02-19 2009-08-27 Novasaid Ab Compounds and methods
EP2332536A1 (en) * 2008-03-05 2011-06-15 MethylGene Inc. Inhibitors of protein tyrosine kinase activity
CN102232071B (en) * 2008-09-26 2016-03-23 财团法人卫生研究院 As the fused-polycyclic compounds of kinases inhibitor
MX2012002596A (en) 2009-09-03 2012-07-03 Allergan Inc Compounds as tyrosine kinase modulators.
US8906944B2 (en) * 2009-09-03 2014-12-09 Allergan, Inc. Compounds as tyrosine kinase modulators

Also Published As

Publication number Publication date
MX2012002591A (en) 2012-04-02
BR112012004718A2 (en) 2017-05-23
CN102498114A (en) 2012-06-13
CA2772625A1 (en) 2011-03-10
EP2473513B1 (en) 2019-06-05
JP2013503901A (en) 2013-02-04
US9725433B2 (en) 2017-08-08
SG178963A1 (en) 2012-04-27
CL2012000587A1 (en) 2012-08-24
AU2010289359A1 (en) 2012-03-29
NZ598781A (en) 2014-05-30
CA2772718C (en) 2018-02-20
AU2010289353B2 (en) 2016-12-08
CL2012000592A1 (en) 2012-08-03
JP6109974B2 (en) 2017-04-05
EP2473513A1 (en) 2012-07-11
WO2011029001A1 (en) 2011-03-10
JP2013503903A (en) 2013-02-04
CA2772718A1 (en) 2011-03-10
KR20120047313A (en) 2012-05-11
US20140100212A1 (en) 2014-04-10
JP2016104785A (en) 2016-06-09
BR112012004843A2 (en) 2019-09-24
AU2010289353A1 (en) 2012-03-29
WO2011028995A1 (en) 2011-03-10
NZ598455A (en) 2014-03-28
US9475801B2 (en) 2016-10-25
US8809534B2 (en) 2014-08-19
IL218374A0 (en) 2012-04-30
RU2012109233A (en) 2013-10-10
US20170066738A1 (en) 2017-03-09
US8614234B2 (en) 2013-12-24
ZA201201592B (en) 2012-11-28
SG178965A1 (en) 2012-04-27
US20110053973A1 (en) 2011-03-03
ZA201201627B (en) 2012-11-28
US20110053905A1 (en) 2011-03-03
CN102686577A (en) 2012-09-19
IL218332A0 (en) 2012-04-30
US20160090372A1 (en) 2016-03-31
PH12014500281A1 (en) 2015-09-07
MX2012002596A (en) 2012-07-03
EP2473501A1 (en) 2012-07-11
RU2012112151A (en) 2013-10-10
US9328103B2 (en) 2016-05-03
KR20120082890A (en) 2012-07-24
ES2730086T3 (en) 2019-11-08
EP2473501B1 (en) 2019-02-20
JP5868855B2 (en) 2016-02-24

Similar Documents

Publication Publication Date Title
PH12014500281A1 (en) Compounds as tyrosine kinase modulators
EA201500175A1 (en) COMPOUNDS AND COMPOSITIONS AS PROTEINKINAZ INHIBITORS
TN2012000171A1 (en) Synthetic methods for spiro-oxindole compounds
MX348451B (en) Derivatives of n- [(1h-pyrazol-1-yl) aryl] - 1h - indole or 1h - indazole - 3 - carboxamide, their preparation and their use as p2y12 antagonists.
TN2011000673A1 (en) Bace inhibitors
MY160468A (en) Novel amino azaheterocyclic carboxamides
MY151246A (en) Benzofuranyl derivatives
MX2010009207A (en) Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors.
MX2011008864A (en) Sulfonylated tetrahydroazolopyrazines and their use as medicinal products.
UA102251C2 (en) Aminidihydrothiazine derivatives as bace inhibitors for the treatment of alzheimer's disease
EA201690391A1 (en) SELECTIVE MODULATORS OF SPHINGOZIN-1-PHOSPHATE RECEPTOR AND METHODS OF CHIRAL SYNTHESIS
MX2009007104A (en) Substituted oxindole derivatives and their use as vasopressin receptor ligands.
WO2011014795A3 (en) Compounds and compositions as syk kinase inhibitors
MX2012001419A (en) Novel bicyclic urea compounds.
MX2013005118A (en) Selective glycosidase inhibitors and uses thereof.
MX2010002899A (en) Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists.
MX2012001413A (en) Novel azaheterocyclic compounds.
EA201290329A1 (en) SELECTIVE HETERROCYCLIC MODULATORS OF SPHINGOZIN-1-PHOSPHATE RECEPTOR
MX2014012266A (en) Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents.
MX2013002851A (en) Inhibitors of notum pectinacetylesterase and methods of their use.
GEP20156315B (en) Oxazoline and isoxazoline derivatives as crac modulators
TN2012000469A1 (en) Use of novel pan-cdk inhibitors for treating tumors
MX2011008126A (en) Substituted indole compounds as bradykinin receptor 1 modulators.
MX2015005312A (en) 1 h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists.
MX2013006670A (en) 2-carboxamide-4-piperazinyl-benzofuran derivative.