IN2012DN00719A - - Google Patents
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- Publication number
- IN2012DN00719A IN2012DN00719A IN719DEN2012A IN2012DN00719A IN 2012DN00719 A IN2012DN00719 A IN 2012DN00719A IN 719DEN2012 A IN719DEN2012 A IN 719DEN2012A IN 2012DN00719 A IN2012DN00719 A IN 2012DN00719A
- Authority
- IN
- India
- Prior art keywords
- compounds
- disorders
- compositions
- useful
- cftr
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102000012605 Cystic Fibrosis Transmembrane Conductance Regulator Human genes 0.000 abstract 4
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000030761 polycystic kidney disease Diseases 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000031513 cyst Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000037427 ion transport Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23274109P | 2009-08-10 | 2009-08-10 | |
| PCT/US2010/045052 WO2011019737A1 (en) | 2009-08-10 | 2010-08-10 | Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosis transmembrane conductance regulator protein and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00719A true IN2012DN00719A (enExample) | 2015-06-19 |
Family
ID=43586433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN719DEN2012 IN2012DN00719A (enExample) | 2009-08-10 | 2010-08-10 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8609661B2 (enExample) |
| EP (1) | EP2464354B1 (enExample) |
| CN (1) | CN102695510A (enExample) |
| CA (1) | CA2769847C (enExample) |
| IN (1) | IN2012DN00719A (enExample) |
| WO (1) | WO2011019737A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012166658A1 (en) * | 2011-05-27 | 2012-12-06 | The Regents Of The University Of California | Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor |
| CN105143230B (zh) * | 2012-12-19 | 2017-06-09 | 诺华股份有限公司 | 用于抑制cftr通道的三环化合物 |
| EA201591175A1 (ru) * | 2012-12-19 | 2015-11-30 | Новартис Аг | Трициклические соединения в качестве ингибиторов cftr |
| GB201905711D0 (en) | 2019-04-24 | 2019-06-05 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of kidney diseases |
| CN114948966B (zh) * | 2022-04-27 | 2023-06-20 | 南京鼓楼医院 | 一种小分子抑制剂在制备治疗多发性硬化和脓毒症的药物中的应用 |
| CN115998763A (zh) * | 2023-01-17 | 2023-04-25 | 暨南大学 | 氯离子及靶向氯离子通道的化合物在调控铁死亡中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751969B1 (fr) * | 1996-08-01 | 1998-12-04 | Centre Nat Rech Scient | Composes activateurs du canal cftr, et compositions pharmaceutiques les contenant |
| GB9626643D0 (en) * | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
| US7235573B2 (en) | 2002-09-30 | 2007-06-26 | The Regents Of The University Of California | Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors |
| EP1646615B1 (en) | 2003-06-06 | 2009-08-26 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as modulators of atp-binding cassette transporters |
| FR2861304B1 (fr) * | 2003-10-23 | 2008-07-18 | Univ Grenoble 1 | Modulateurs des canaux cftr |
| EP1740532A4 (en) | 2004-03-30 | 2009-06-10 | Univ California | CFTR INHIBITOR COMPOUNDS CONTAINING HYDRAZIDS AND USES THEREOF |
| US7563793B2 (en) * | 2004-12-20 | 2009-07-21 | Wyeth | Pyrrolo[1,2-a]quinoxalin-5-(4H)-yl)sulfonyls and carbonyls and their use as estrogenic agents |
| JP2010523579A (ja) * | 2007-04-02 | 2010-07-15 | インスティテュート フォア ワンワールド ヘルス | Ｃｆｔｒ阻害剤化合物およびそれらの使用 |
| WO2009076593A1 (en) * | 2007-12-13 | 2009-06-18 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| KR20100134063A (ko) | 2008-03-25 | 2010-12-22 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 낭포성 섬유증 막투과 전도성 조절자의 수용성 소분자 억제제 |
| BRPI0910416A2 (pt) | 2008-04-04 | 2019-09-24 | Univ California | conjugados de composto de hidrazia divalente para inibir regulador de condutância de transmembrana de fibrose cística |
| WO2012166658A1 (en) | 2011-05-27 | 2012-12-06 | The Regents Of The University Of California | Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor |
-
2010
- 2010-08-10 WO PCT/US2010/045052 patent/WO2011019737A1/en not_active Ceased
- 2010-08-10 EP EP10808643.0A patent/EP2464354B1/en active Active
- 2010-08-10 CN CN2010800427350A patent/CN102695510A/zh active Pending
- 2010-08-10 US US13/389,898 patent/US8609661B2/en active Active
- 2010-08-10 IN IN719DEN2012 patent/IN2012DN00719A/en unknown
- 2010-08-10 CA CA2769847A patent/CA2769847C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120208822A1 (en) | 2012-08-16 |
| CA2769847C (en) | 2019-01-08 |
| WO2011019737A1 (en) | 2011-02-17 |
| US8609661B2 (en) | 2013-12-17 |
| CA2769847A1 (en) | 2011-02-17 |
| EP2464354A1 (en) | 2012-06-20 |
| EP2464354A4 (en) | 2013-03-27 |
| EP2464354B1 (en) | 2015-04-01 |
| CN102695510A (zh) | 2012-09-26 |
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