IN2012DN00411A - - Google Patents

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Publication number
IN2012DN00411A
IN2012DN00411A IN411DEN2012A IN2012DN00411A IN 2012DN00411 A IN2012DN00411 A IN 2012DN00411A IN 411DEN2012 A IN411DEN2012 A IN 411DEN2012A IN 2012DN00411 A IN2012DN00411 A IN 2012DN00411A
Authority
IN
India
Prior art keywords
morpholinone
nitrating
nitrophenyl
phenyl
preparing
Prior art date
Application number
Inventor
Thomas Christian
Berwe Mathias
Straub Alexander
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of IN2012DN00411A publication Critical patent/IN2012DN00411A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

A process for preparing 4-(4-nitrophenyl)-3-morpholinone wherein the said compound is prepared by nitrating 4-phenyl-3-morpholinone.
IN411DEN2012 2003-09-15 2004-09-09 IN2012DN00411A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10342570A DE10342570A1 (en) 2003-09-15 2003-09-15 Process for the preparation of 4- (4-aminophenyl) -3-morpholinone
PCT/EP2004/010054 WO2005026135A1 (en) 2003-09-15 2004-09-09 Method for the production of 4-(4-aminophenyl)-3-morpholinon

Publications (1)

Publication Number Publication Date
IN2012DN00411A true IN2012DN00411A (en) 2015-08-21

Family

ID=34305779

Family Applications (1)

Application Number Title Priority Date Filing Date
IN411DEN2012 IN2012DN00411A (en) 2003-09-15 2004-09-09

Country Status (23)

Country Link
US (1) US7598378B2 (en)
EP (1) EP1664004B1 (en)
JP (1) JP4852419B2 (en)
KR (1) KR101148264B1 (en)
CN (1) CN100430384C (en)
AU (1) AU2004272255B2 (en)
BR (1) BRPI0414382B1 (en)
CA (1) CA2538906C (en)
CY (1) CY1116644T1 (en)
DE (1) DE10342570A1 (en)
DK (1) DK1664004T3 (en)
EG (1) EG26605A (en)
ES (1) ES2545072T3 (en)
HK (1) HK1098134A1 (en)
HU (1) HUE025273T2 (en)
IL (1) IL174194A (en)
IN (1) IN2012DN00411A (en)
MX (1) MXPA06002883A (en)
PL (1) PL1664004T3 (en)
PT (1) PT1664004E (en)
SI (1) SI1664004T1 (en)
WO (1) WO2005026135A1 (en)
ZA (1) ZA200602093B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100898361B1 (en) 2008-07-03 2009-05-20 주식회사 레고켐 바이오사이언스 Fxa inhibitors with cyclic amidoxime or cyclic amidrazone as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
EP2521723A1 (en) * 2010-01-04 2012-11-14 Enantia, S.L. Process for the preparation of rivaroxaban and intermediates thereof
DE102010018299A1 (en) * 2010-04-23 2011-10-27 Archimica Gmbh Process for the preparation of 4- (4-aminophenyl) -morpholin-3-one
US20130172554A1 (en) * 2010-09-07 2013-07-04 Symed Labs Limited Processes for the preparation of 4-morpholin-3-one
WO2012051692A1 (en) 2010-10-18 2012-04-26 Apotex Pharmachem Inc. Processes for the preparation of rivaroxaban and intermediates thereof
US9221771B2 (en) 2011-04-11 2015-12-29 Sandoz Ag Method for the preparation of substituted oxazolidinones
JP6325978B2 (en) * 2011-05-06 2018-05-16 エギシュ ヂョヂセルヂャール ザートケルエン ミケデ レースヴェーニタールササーグ Process for the preparation of rivaroxaban and intermediates formed in the process
WO2012156983A1 (en) * 2011-05-16 2012-11-22 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
CN102320988B (en) * 2011-06-03 2014-04-09 中国科学院上海有机化学研究所 4-(4-amion phenyl)-3-morpholone intermediate amide and synthesis method and application thereof
CN103288814B (en) * 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 A kind of preparation method of Rivaroxaban intermediate
CN102746288B (en) * 2012-07-24 2015-04-08 常州制药厂有限公司 Preparation methods of anticoagulant and key intermediate of anticoagulant
US9663505B2 (en) 2013-03-25 2017-05-30 Glenmark Pharmaceuticals Limited Process for the preparation of rivaroxaban
KR20140127651A (en) * 2013-04-25 2014-11-04 주식회사 종근당 Novel Process For Preparation Of 4-(4-Aminophenyl)-3-Morpholinone
CN103232446B (en) * 2013-05-17 2015-09-23 天津药物研究院 Yi Zhong oxazolidinone derivative crystal form II and its production and use
EP3066098A1 (en) 2013-11-08 2016-09-14 Bayer Pharma Aktiengesellschaft Substituted uracils and use thereof
CN103709116B (en) * 2013-12-10 2015-09-23 四川大学 A kind of preparation method of 4-(4-alkoxycarbonylamino) phenyl-3-morpholone mai
CN103755657B (en) * 2013-12-25 2015-10-14 湖南方盛制药股份有限公司 A kind of preparation method of Rivaroxaban intermediate
CN104974059B (en) * 2014-04-14 2016-11-16 北大方正集团有限公司 A kind of Rivaroxaban intermediate and preparation method thereof
CN105085370B (en) * 2014-04-22 2017-04-12 北大方正集团有限公司 (S)-1-halo-2-[2-(1,3-dioxo-isoindol)yl]ethyl chloroformate and preparation method thereof
EP3186246A1 (en) 2014-08-25 2017-07-05 Cipla Limited Process for the preparation of rivaroxaban
CN104478820B (en) * 2014-12-22 2016-08-31 杭州瀚康生物医药科技有限公司 A kind of preparation method of Rivaroxaban intermediate
CN104817548B (en) * 2015-03-19 2017-12-01 郑州轻工业学院 A kind of organic molecule that Selective recognition is visualized to lithium hydroxide, sodium hydroxide, potassium hydroxide
HU231119B1 (en) 2018-01-12 2020-11-30 Richter Gedeon Nyrt. Process for the preparation of 4-(4-aminophenyl) morpholin-3-one
CN109651287A (en) * 2019-01-18 2019-04-19 吕东 A kind of preparation method of 4- (4- aminophenyl) morpholone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3279880A (en) 1965-07-12 1966-10-18 Eastman Kodak Co Polyester textile material dyed with 1-hydroxy-4-n-p-(2'-pyrrolidonyl-1-) phenyl-amino anthraquinones
GB8528633D0 (en) * 1985-11-21 1985-12-24 Beecham Group Plc Compounds
CA2195107A1 (en) * 1994-08-02 1996-02-15 Richard Alexander Jelley Azetidine, pyrrolidine and piperidine derivatives
AU721130B2 (en) * 1996-06-28 2000-06-22 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19962924A1 (en) 1999-12-24 2001-07-05 Bayer Ag Substituted oxazolidinones and their use
DE10105989A1 (en) * 2001-02-09 2002-08-14 Bayer Ag Substituted oxazolidinones and their use
DE10129725A1 (en) 2001-06-20 2003-01-02 Bayer Ag Combination therapy of substituted oxazolidinones
EP1479675A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
EP1479676A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Benzimidazole-derivatives as factor xa inhibitors

Also Published As

Publication number Publication date
BRPI0414382A (en) 2006-11-21
JP4852419B2 (en) 2012-01-11
AU2004272255B2 (en) 2011-01-06
US20070066611A1 (en) 2007-03-22
DE10342570A1 (en) 2005-04-14
HUE025273T2 (en) 2016-02-29
CY1116644T1 (en) 2017-03-15
PL1664004T3 (en) 2015-11-30
AU2004272255A1 (en) 2005-03-24
BRPI0414382B1 (en) 2014-01-28
EG26605A (en) 2014-03-23
KR20060070561A (en) 2006-06-23
CN100430384C (en) 2008-11-05
JP2007505821A (en) 2007-03-15
CA2538906C (en) 2013-04-23
KR101148264B1 (en) 2012-05-21
HK1098134A1 (en) 2007-07-13
US7598378B2 (en) 2009-10-06
PT1664004E (en) 2015-09-21
CN1852902A (en) 2006-10-25
EP1664004A1 (en) 2006-06-07
SI1664004T1 (en) 2015-10-30
ES2545072T3 (en) 2015-09-08
CA2538906A1 (en) 2005-03-24
IL174194A0 (en) 2006-08-01
WO2005026135A1 (en) 2005-03-24
ZA200602093B (en) 2007-05-30
DK1664004T3 (en) 2015-09-07
IL174194A (en) 2010-11-30
MXPA06002883A (en) 2006-06-05
EP1664004B1 (en) 2015-06-24

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