IN2012CN09242A - - Google Patents
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- Publication number
- IN2012CN09242A IN2012CN09242A IN9242CHN2012A IN2012CN09242A IN 2012CN09242 A IN2012CN09242 A IN 2012CN09242A IN 9242CHN2012 A IN9242CHN2012 A IN 9242CHN2012A IN 2012CN09242 A IN2012CN09242 A IN 2012CN09242A
- Authority
- IN
- India
- Prior art keywords
- halogen
- single bond
- independently hydrogen
- compound
- hydrogen
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D505/10—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D505/12—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7
- C07D505/14—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 substituted in position 7 with hetero atoms directly attached in position 7
- C07D505/16—Nitrogen atoms
- C07D505/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D505/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D505/24—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by doubly-bound nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Abstract A compound of the formula: wherein X is -N=, -CH=, or the like; W is -CH2- or the like; U is -S- or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; R3 is hydrogen or the like; each R4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; Q is a single bond, or the like; G is -C(=0)-, or the like; D is a single bond, -NH-, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010087131 | 2010-04-05 | ||
JP2010274180 | 2010-12-09 | ||
PCT/JP2011/058498 WO2011125967A1 (en) | 2010-04-05 | 2011-04-04 | Cephem compound having catechol group |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012CN09242A true IN2012CN09242A (en) | 2015-08-21 |
Family
ID=44762902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN9242CHN2012 IN2012CN09242A (en) | 2010-04-05 | 2011-04-04 |
Country Status (14)
Country | Link |
---|---|
US (1) | US9145425B2 (en) |
EP (1) | EP2557082A4 (en) |
JP (1) | JP5909441B2 (en) |
KR (1) | KR20130018845A (en) |
CN (1) | CN102918048A (en) |
AR (1) | AR081758A1 (en) |
AU (1) | AU2011236933A1 (en) |
CA (1) | CA2795322A1 (en) |
IN (1) | IN2012CN09242A (en) |
MX (1) | MX2012011521A (en) |
RU (1) | RU2012146986A (en) |
TW (1) | TW201139451A (en) |
UY (1) | UY33315A (en) |
WO (1) | WO2011125967A1 (en) |
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WO2009049086A1 (en) | 2007-10-09 | 2009-04-16 | Larry Sutton | Broad spectrum beta-lactamase inhibitors |
HUE031802T2 (en) * | 2008-10-31 | 2017-08-28 | Shionogi & Co | Cephalosporin having catechol group |
CN102918047A (en) * | 2010-04-05 | 2013-02-06 | 盐野义制药株式会社 | Cephem compound having pseudo-catechol group |
US9085589B2 (en) * | 2010-04-28 | 2015-07-21 | Shionogi & Co., Ltd. | Cephem derivative |
WO2012147773A1 (en) | 2011-04-28 | 2012-11-01 | 塩野義製薬株式会社 | Novel cephem compound having catechol or pseudo-catechol structure |
WO2013002215A1 (en) | 2011-06-27 | 2013-01-03 | 塩野義製薬株式会社 | Cephem compound having pyridinium group |
TWI547496B (en) * | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | Antibacterial compounds |
JPWO2013051597A1 (en) | 2011-10-04 | 2015-03-30 | 塩野義製薬株式会社 | Cephem derivatives with catechol groups |
UY35103A (en) | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | 2-REPLACED CEFEM COMPOUNDS |
AU2013339040A1 (en) | 2012-10-29 | 2015-04-30 | Shionogi & Co., Ltd. | Processes for production of intermediates for 2-alkyl cephem compounds |
US9139743B2 (en) * | 2013-01-31 | 2015-09-22 | Xerox Corporation | Malic acid derivatives as amorphous materials for phase change ink |
AU2015312828B2 (en) * | 2014-09-04 | 2020-02-13 | Shionogi & Co., Ltd. | Salt of cephalosporin derivative, crystalline solid form of same and method for producing same |
WO2016035847A1 (en) * | 2014-09-04 | 2016-03-10 | 塩野義製薬株式会社 | Intermediate of cephalosporin derivatives and method for producing same |
CN104817604B (en) * | 2015-03-16 | 2017-08-04 | 邦泰生物工程(深圳)有限公司 | A kind of purification process of β nicotinamide mononucleotides |
AU2016275764B8 (en) | 2015-06-11 | 2021-03-04 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
CN108463461B (en) * | 2015-12-10 | 2021-11-19 | 奈加-Rgm制药有限公司 | Cephem compounds, their preparation and use |
WO2017199227A1 (en) | 2016-05-20 | 2017-11-23 | S & I Ophthalmic, Llc. | Process for preparation of 3,4-dihydroxy-2-methyl benzoic acid alkylester |
WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
AR116020A1 (en) | 2018-09-03 | 2021-03-25 | Bayer Ag | 3,9-DIAZAESPIRO [5.5] UNDECANO COMPOUNDS AS GGTase I INHIBITORS AND THEIR USE FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES |
US20220002288A1 (en) * | 2018-11-13 | 2022-01-06 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Monobactam compounds and use therefor |
WO2020184399A1 (en) * | 2019-03-08 | 2020-09-17 | 塩野義製薬株式会社 | Antibacterial pharmaceutical composition |
WO2020206381A1 (en) * | 2019-04-03 | 2020-10-08 | Sutton Larry D | Cephem compounds with latent reactive groups and methods of using and making same |
CA3165565A1 (en) * | 2020-01-22 | 2021-07-29 | Jian Huang | Cephalosporin antibacterial compound and pharmaceutical application thereof |
IL295477A (en) | 2020-02-11 | 2022-10-01 | Cheminova As | Process for the synthesis of s-beflubutamid from (r)-2-aminobutanoic acid |
GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
CN111714490B (en) * | 2020-07-20 | 2021-07-06 | 广东工业大学 | Application of compound in preparation of medicine for inhibiting bacterial quorum sensing system |
CA3204655A1 (en) * | 2021-01-12 | 2022-07-21 | Jian Huang | Cephalosporin antibacterial compound and preparation method therefor |
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-
2011
- 2011-04-04 EP EP11765867.4A patent/EP2557082A4/en not_active Withdrawn
- 2011-04-04 AU AU2011236933A patent/AU2011236933A1/en not_active Abandoned
- 2011-04-04 CA CA2795322A patent/CA2795322A1/en not_active Abandoned
- 2011-04-04 KR KR1020127028893A patent/KR20130018845A/en not_active Application Discontinuation
- 2011-04-04 WO PCT/JP2011/058498 patent/WO2011125967A1/en active Application Filing
- 2011-04-04 CN CN2011800277729A patent/CN102918048A/en active Pending
- 2011-04-04 IN IN9242CHN2012 patent/IN2012CN09242A/en unknown
- 2011-04-04 JP JP2012509646A patent/JP5909441B2/en not_active Expired - Fee Related
- 2011-04-04 RU RU2012146986/04A patent/RU2012146986A/en not_active Application Discontinuation
- 2011-04-04 MX MX2012011521A patent/MX2012011521A/en not_active Application Discontinuation
- 2011-04-04 US US13/639,412 patent/US9145425B2/en not_active Expired - Fee Related
- 2011-04-05 AR ARP110101141A patent/AR081758A1/en unknown
- 2011-04-05 UY UY0001033315A patent/UY33315A/en not_active Application Discontinuation
- 2011-04-06 TW TW100111734A patent/TW201139451A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN102918048A (en) | 2013-02-06 |
WO2011125967A1 (en) | 2011-10-13 |
AR081758A1 (en) | 2012-10-17 |
US20130102583A1 (en) | 2013-04-25 |
UY33315A (en) | 2011-10-31 |
US9145425B2 (en) | 2015-09-29 |
MX2012011521A (en) | 2013-03-08 |
EP2557082A4 (en) | 2013-08-28 |
TW201139451A (en) | 2011-11-16 |
JPWO2011125967A1 (en) | 2013-07-11 |
CA2795322A1 (en) | 2011-10-13 |
EP2557082A1 (en) | 2013-02-13 |
JP5909441B2 (en) | 2016-04-26 |
RU2012146986A (en) | 2014-05-20 |
AU2011236933A1 (en) | 2013-05-02 |
KR20130018845A (en) | 2013-02-25 |
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