IL99172A - Reverse oligonucleotides corresponding to gene B of the herpes simplex virus type 1 that are active as antiviral agents and their use - Google Patents

Reverse oligonucleotides corresponding to gene B of the herpes simplex virus type 1 that are active as antiviral agents and their use

Info

Publication number
IL99172A
IL99172A IL9917291A IL9917291A IL99172A IL 99172 A IL99172 A IL 99172A IL 9917291 A IL9917291 A IL 9917291A IL 9917291 A IL9917291 A IL 9917291A IL 99172 A IL99172 A IL 99172A
Authority
IL
Israel
Prior art keywords
oligomer
virus
gene
use according
target sequence
Prior art date
Application number
IL9917291A
Other languages
English (en)
Hebrew (he)
Other versions
IL99172A0 (en
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Publication of IL99172A0 publication Critical patent/IL99172A0/xx
Publication of IL99172A publication Critical patent/IL99172A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1133—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against herpetoviridae, e.g. HSV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL9917291A 1990-08-15 1991-08-13 Reverse oligonucleotides corresponding to gene B of the herpes simplex virus type 1 that are active as antiviral agents and their use IL99172A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56850190A 1990-08-15 1990-08-15

Publications (2)

Publication Number Publication Date
IL99172A0 IL99172A0 (en) 1992-07-15
IL99172A true IL99172A (en) 1999-03-12

Family

ID=24271562

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9917291A IL99172A (en) 1990-08-15 1991-08-13 Reverse oligonucleotides corresponding to gene B of the herpes simplex virus type 1 that are active as antiviral agents and their use

Country Status (10)

Country Link
EP (1) EP0547149A4 (fr)
JP (1) JPH06500469A (fr)
KR (1) KR930701105A (fr)
AU (2) AU8617691A (fr)
CA (1) CA2089476A1 (fr)
IE (1) IE912883A1 (fr)
IL (1) IL99172A (fr)
NZ (1) NZ239372A (fr)
TW (1) TW226408B (fr)
WO (1) WO1992003051A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2105595A1 (fr) * 1992-09-23 1994-03-24 Ramaswamy Narayanan Polynucleotides antisens
WO1995032986A1 (fr) * 1994-06-01 1995-12-07 Hybridon, Inc. Oligonucleotides ramifies inhibiteurs des agents pathogenes
AU713611B2 (en) 1994-10-28 1999-12-09 Delft Diagnostic Laboratory B.V. New polynucleic acid sequences for use in the detection and differentiation of prokaryotic organisms
CA2223032A1 (fr) * 1997-02-21 1998-08-21 Smithkline Beecham Corporation Utilisation de ul-15 et de vp5 du hsv-1 pour la detection d'agents antiviraux
EP2330194A3 (fr) 2002-09-13 2011-10-12 Replicor, Inc. Oligonucléotides antiviraux non complémentaires de séquence

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ209840A (en) * 1983-10-17 1988-11-29 Kaji Akira A method of inhibiting viral propagation by hybridising dna with the viral rna thus blocking its action
US5248670A (en) * 1990-02-26 1993-09-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotides for inhibiting herpesviruses
CA2092711A1 (fr) * 1990-09-21 1992-03-22 Laure Aurelian Compositions et methodes permettant d'inhiber la croissance ou la replication des virus

Also Published As

Publication number Publication date
AU8617691A (en) 1992-03-17
WO1992003051A1 (fr) 1992-03-05
EP0547149A4 (en) 1993-09-01
CA2089476A1 (fr) 1992-02-16
TW226408B (fr) 1994-07-11
JPH06500469A (ja) 1994-01-20
IE912883A1 (en) 1992-02-26
KR930701105A (ko) 1993-06-11
NZ239372A (en) 1997-06-24
AU3776395A (en) 1996-02-29
IL99172A0 (en) 1992-07-15
EP0547149A1 (fr) 1993-06-23

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