IL98636A - Monoclonal antibodies to microsperla strains, their production and preparations containing them - Google Patents
Monoclonal antibodies to microsperla strains, their production and preparations containing themInfo
- Publication number
- IL98636A IL98636A IL9863691A IL9863691A IL98636A IL 98636 A IL98636 A IL 98636A IL 9863691 A IL9863691 A IL 9863691A IL 9863691 A IL9863691 A IL 9863691A IL 98636 A IL98636 A IL 98636A
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- mycosphaerella
- species
- cell line
- reacts
- Prior art date
Links
- 241000131448 Mycosphaerella Species 0.000 title claims abstract description 90
- 239000000203 mixture Substances 0.000 title claims description 20
- 238000004519 manufacturing process Methods 0.000 title description 8
- 238000000034 method Methods 0.000 claims abstract description 62
- 210000004408 hybridoma Anatomy 0.000 claims abstract description 61
- 241000894007 species Species 0.000 claims abstract description 56
- 210000004027 cell Anatomy 0.000 claims description 68
- 239000000427 antigen Substances 0.000 claims description 67
- 102000036639 antigens Human genes 0.000 claims description 64
- 108091007433 antigens Proteins 0.000 claims description 64
- 241000087479 Pseudocercospora fijiensis Species 0.000 claims description 63
- 241001360088 Zymoseptoria tritici Species 0.000 claims description 55
- 102000004190 Enzymes Human genes 0.000 claims description 22
- 108090000790 Enzymes Proteins 0.000 claims description 22
- 230000004927 fusion Effects 0.000 claims description 20
- 241001465754 Metazoa Species 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 13
- 241000184297 Pseudocercospora musae Species 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 11
- 238000009739 binding Methods 0.000 claims description 9
- 230000003053 immunization Effects 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 238000010367 cloning Methods 0.000 claims description 3
- 238000009007 Diagnostic Kit Methods 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000001900 immune effect Effects 0.000 claims description 2
- 230000016784 immunoglobulin production Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 26
- 208000015181 infectious disease Diseases 0.000 abstract description 7
- 239000002609 medium Substances 0.000 description 23
- 239000000243 solution Substances 0.000 description 23
- 229940088598 enzyme Drugs 0.000 description 20
- 241000196324 Embryophyta Species 0.000 description 17
- 239000000725 suspension Substances 0.000 description 16
- 230000002538 fungal effect Effects 0.000 description 15
- 239000000523 sample Substances 0.000 description 15
- 206010035226 Plasma cell myeloma Diseases 0.000 description 14
- 201000010099 disease Diseases 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 201000000050 myeloid neoplasm Diseases 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 13
- 238000003556 assay Methods 0.000 description 13
- 244000052769 pathogen Species 0.000 description 13
- 230000001717 pathogenic effect Effects 0.000 description 13
- 239000006228 supernatant Substances 0.000 description 13
- 229920001817 Agar Polymers 0.000 description 12
- 102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 description 12
- 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 12
- 239000008272 agar Substances 0.000 description 12
- 238000003018 immunoassay Methods 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- -1 acridinium esters Chemical class 0.000 description 11
- 239000000872 buffer Substances 0.000 description 11
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 239000008188 pellet Substances 0.000 description 11
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 10
- 241000209140 Triticum Species 0.000 description 10
- 235000021307 Triticum Nutrition 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 10
- 241000228212 Aspergillus Species 0.000 description 9
- 240000005561 Musa balbisiana Species 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 241000190150 Bipolaris sorokiniana Species 0.000 description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 8
- 241000233866 Fungi Species 0.000 description 8
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 8
- 230000027455 binding Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 241001149956 Cladosporium herbarum Species 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 239000004793 Polystyrene Substances 0.000 description 7
- 241000235546 Rhizopus stolonifer Species 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 229920002223 polystyrene Polymers 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 238000012216 screening Methods 0.000 description 7
- ZTOJFFHGPLIVKC-YAFCTCPESA-N (2e)-3-ethyl-2-[(z)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound S\1C2=CC(S(O)(=O)=O)=CC=C2N(CC)C/1=N/N=C1/SC2=CC(S(O)(=O)=O)=CC=C2N1CC ZTOJFFHGPLIVKC-YAFCTCPESA-N 0.000 description 6
- LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 description 6
- 241000222290 Cladosporium Species 0.000 description 6
- 241000745230 Corynespora torulosa Species 0.000 description 6
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 6
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- 238000003149 assay kit Methods 0.000 description 6
- 239000006285 cell suspension Substances 0.000 description 6
- 244000053095 fungal pathogen Species 0.000 description 6
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 6
- 238000002649 immunization Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000002054 inoculum Substances 0.000 description 6
- 229960000485 methotrexate Drugs 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 210000004989 spleen cell Anatomy 0.000 description 6
- TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 5
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 5
- 241000223600 Alternaria Species 0.000 description 5
- 241001149955 Cladosporium cladosporioides Species 0.000 description 5
- 241000222199 Colletotrichum Species 0.000 description 5
- 241001492222 Epicoccum Species 0.000 description 5
- 241000223218 Fusarium Species 0.000 description 5
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 5
- 241000308171 Metulocladosporiella musae Species 0.000 description 5
- 241000228143 Penicillium Species 0.000 description 5
- 241001503951 Phoma Species 0.000 description 5
- 239000000654 additive Substances 0.000 description 5
- 229960003896 aminopterin Drugs 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 230000009260 cross reactivity Effects 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 210000004754 hybrid cell Anatomy 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 4
- 241000223602 Alternaria alternata Species 0.000 description 4
- 241000235349 Ascomycota Species 0.000 description 4
- 241001465318 Aspergillus terreus Species 0.000 description 4
- 241000750642 Aspergillus varians Species 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241001450781 Bipolaris oryzae Species 0.000 description 4
- 241000123650 Botrytis cinerea Species 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 241000346819 Cladosporium macrocarpum Species 0.000 description 4
- 241000223211 Curvularia lunata Species 0.000 description 4
- 241001029934 Deightoniella Species 0.000 description 4
- 241001506775 Epicoccum nigrum Species 0.000 description 4
- 241000223221 Fusarium oxysporum Species 0.000 description 4
- 108010015776 Glucose oxidase Proteins 0.000 description 4
- 239000004366 Glucose oxidase Substances 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 241001518800 Lambertella subrenispora Species 0.000 description 4
- 241000190144 Lasiodiplodia theobromae Species 0.000 description 4
- 241001518729 Monilinia Species 0.000 description 4
- 241001459558 Monographella nivalis Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 241001518724 Myriosclerotinia dennisii Species 0.000 description 4
- 241001365887 Neocordana musae Species 0.000 description 4
- 241001494479 Pecora Species 0.000 description 4
- 241000190117 Pyrenophora tritici-repentis Species 0.000 description 4
- 241000918585 Pythium aphanidermatum Species 0.000 description 4
- 241000813090 Rhizoctonia solani Species 0.000 description 4
- 241000221696 Sclerotinia sclerotiorum Species 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000008121 dextrose Substances 0.000 description 4
- 238000007865 diluting Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 239000000417 fungicide Substances 0.000 description 4
- 229940116332 glucose oxidase Drugs 0.000 description 4
- 235000019420 glucose oxidase Nutrition 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 239000004800 polyvinyl chloride Substances 0.000 description 4
- 229920000915 polyvinyl chloride Polymers 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000011534 wash buffer Substances 0.000 description 4
- 241001225321 Aspergillus fumigatus Species 0.000 description 3
- 241000221198 Basidiomycota Species 0.000 description 3
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 3
- 241000499339 Botrytis allii Species 0.000 description 3
- 241001429695 Colletotrichum graminicola Species 0.000 description 3
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 3
- 241000133054 Mortierella epigama Species 0.000 description 3
- 241000907975 Mortierella gamsii Species 0.000 description 3
- 102000003992 Peroxidases Human genes 0.000 description 3
- 241000276498 Pollachius virens Species 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- 206010070834 Sensitisation Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241001065163 Zasmidium musigenum Species 0.000 description 3
- 210000000628 antibody-producing cell Anatomy 0.000 description 3
- 229940091771 aspergillus fumigatus Drugs 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 102000005936 beta-Galactosidase Human genes 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000000054 fungal extract Substances 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 description 3
- 244000000003 plant pathogen Species 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 230000008313 sensitization Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- 229940104230 thymidine Drugs 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 2
- PCDWFBFHIIKIPM-UHFFFAOYSA-N 3-ethyl-2h-1,3-benzothiazole-2-sulfonic acid Chemical compound C1=CC=C2N(CC)C(S(O)(=O)=O)SC2=C1 PCDWFBFHIIKIPM-UHFFFAOYSA-N 0.000 description 2
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 2
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 2
- 108010022752 Acetylcholinesterase Proteins 0.000 description 2
- 102000012440 Acetylcholinesterase Human genes 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 238000009631 Broth culture Methods 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 102000003846 Carbonic anhydrases Human genes 0.000 description 2
- 108090000209 Carbonic anhydrases Proteins 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 241001273467 Didymella pinodes Species 0.000 description 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 2
- 102100022624 Glucoamylase Human genes 0.000 description 2
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 241000308375 Graminicola Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 108010026217 Malate Dehydrogenase Proteins 0.000 description 2
- 102000013460 Malate Dehydrogenase Human genes 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 241000736122 Parastagonospora nodorum Species 0.000 description 2
- 241000233622 Phytophthora infestans Species 0.000 description 2
- 241001421802 Ramularia grevilleana Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 2
- 241000221561 Ustilaginales Species 0.000 description 2
- 229940022698 acetylcholinesterase Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000000340 anti-metabolite Effects 0.000 description 2
- 229940100197 antimetabolite Drugs 0.000 description 2
- 239000002256 antimetabolite Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000013399 early diagnosis Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000035611 feeding Effects 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 238000010185 immunofluorescence analysis Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 230000011987 methylation Effects 0.000 description 2
- 238000007069 methylation reaction Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- 150000003212 purines Chemical class 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000013595 supernatant sample Substances 0.000 description 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- OBYNJKLOYWCXEP-UHFFFAOYSA-N 2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-4-isothiocyanatobenzoate Chemical compound C=12C=CC(=[N+](C)C)C=C2OC2=CC(N(C)C)=CC=C2C=1C1=CC(N=C=S)=CC=C1C([O-])=O OBYNJKLOYWCXEP-UHFFFAOYSA-N 0.000 description 1
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 description 1
- ZTOJFFHGPLIVKC-UHFFFAOYSA-N 3-ethyl-2-[(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound S1C2=CC(S(O)(=O)=O)=CC=C2N(CC)C1=NN=C1SC2=CC(S(O)(=O)=O)=CC=C2N1CC ZTOJFFHGPLIVKC-UHFFFAOYSA-N 0.000 description 1
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229960005508 8-azaguanine Drugs 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 244000075850 Avena orientalis Species 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 241001465180 Botrytis Species 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 235000018783 Dacrycarpus dacrydioides Nutrition 0.000 description 1
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001661267 Marssonina rosae Species 0.000 description 1
- 241000711408 Murine respirovirus Species 0.000 description 1
- 235000003805 Musa ABB Group Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001668536 Oculimacula yallundae Species 0.000 description 1
- 241001465315 Ophiosphaerella korrae Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- 244000062780 Petroselinum sativum Species 0.000 description 1
- 241000975369 Phoma betae Species 0.000 description 1
- 240000007320 Pinus strobus Species 0.000 description 1
- 235000008578 Pinus strobus Nutrition 0.000 description 1
- 235000015266 Plantago major Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000221535 Pucciniales Species 0.000 description 1
- 241000233612 Pythiaceae Species 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241001361634 Rhizoctonia Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- 241001533598 Septoria Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 241000266365 Stemphylium vesicarium Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241001286670 Ulmus x hollandica Species 0.000 description 1
- 241000228452 Venturia inaequalis Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 238000007630 basic procedure Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012677 causal agent Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003593 chromogenic compound Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 238000002967 competitive immunoassay Methods 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- JSRLJPSBLDHEIO-SHYZEUOFSA-N dUMP Chemical compound O1[C@H](COP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 JSRLJPSBLDHEIO-SHYZEUOFSA-N 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000009088 enzymatic function Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004362 fungal culture Methods 0.000 description 1
- 244000000004 fungal plant pathogen Species 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- WHWDWIHXSPCOKZ-UHFFFAOYSA-N hexahydrofarnesyl acetone Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)=O WHWDWIHXSPCOKZ-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 230000021121 meiosis Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 108060006184 phycobiliprotein Proteins 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000006825 purine synthesis Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000032255 sexual sporulation Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 235000015192 vegetable juice Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54634190A | 1990-06-29 | 1990-06-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL98636A0 IL98636A0 (en) | 1992-07-15 |
| IL98636A true IL98636A (en) | 1995-07-31 |
Family
ID=24179988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9863691A IL98636A (en) | 1990-06-29 | 1991-06-27 | Monoclonal antibodies to microsperla strains, their production and preparations containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5558997A (de) |
| EP (1) | EP0465415B1 (de) |
| JP (1) | JP3182696B2 (de) |
| AT (1) | ATE148162T1 (de) |
| AU (2) | AU7942791A (de) |
| CA (1) | CA2045875C (de) |
| DE (1) | DE69124294T2 (de) |
| DK (1) | DK0465415T3 (de) |
| ES (1) | ES2099147T3 (de) |
| GR (1) | GR3022368T3 (de) |
| HK (1) | HK1003007A1 (de) |
| IE (1) | IE912278A1 (de) |
| IL (1) | IL98636A (de) |
| NZ (1) | NZ238733A (de) |
| PT (1) | PT98106B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003016352A1 (en) * | 2001-08-10 | 2003-02-27 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Monoclonal antibodies against fungi and methods for their use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845197A (en) * | 1985-09-09 | 1989-07-04 | Agri-Diagnostics Associates | Monoclonal antibodies and methods for fungal pathogen detection |
| US4803155A (en) * | 1986-02-27 | 1989-02-07 | Agri-Diagnostics Associates | Monoclonal antibodies to Sclerotinia homoeocarpa |
| US5187064A (en) * | 1986-02-27 | 1993-02-16 | Agri-Diagnostics Associates | Monoclonal antibodies and methods for fungal pathogen detection |
| US5047207A (en) * | 1986-05-20 | 1991-09-10 | Agri-Diagnostics Associates | Kit for diagnosing plant diseases |
| US4997764A (en) * | 1987-04-23 | 1991-03-05 | New York University | Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors |
| US4879217A (en) * | 1987-04-28 | 1989-11-07 | Agri-Diagnostics Associates | Test for Rhizoctonia brown and yellow patch |
| ZW9888A1 (en) * | 1987-07-24 | 1989-02-22 | Ciba Geigy Ag | Monoclonal antibodies and methods for diagnosis of pytophthora infection |
-
1991
- 1991-06-20 DK DK91810484.5T patent/DK0465415T3/da active
- 1991-06-20 DE DE69124294T patent/DE69124294T2/de not_active Expired - Fee Related
- 1991-06-20 ES ES91810484T patent/ES2099147T3/es not_active Expired - Lifetime
- 1991-06-20 AT AT91810484T patent/ATE148162T1/de not_active IP Right Cessation
- 1991-06-20 EP EP91810484A patent/EP0465415B1/de not_active Expired - Lifetime
- 1991-06-27 IL IL9863691A patent/IL98636A/en not_active IP Right Cessation
- 1991-06-27 CA CA002045875A patent/CA2045875C/en not_active Expired - Lifetime
- 1991-06-27 PT PT98106A patent/PT98106B/pt not_active IP Right Cessation
- 1991-06-27 NZ NZ238733A patent/NZ238733A/en not_active IP Right Cessation
- 1991-06-28 IE IE227891A patent/IE912278A1/en not_active IP Right Cessation
- 1991-06-28 JP JP18354691A patent/JP3182696B2/ja not_active Expired - Fee Related
- 1991-06-28 AU AU79427/91A patent/AU7942791A/en not_active Abandoned
-
1994
- 1994-09-26 US US08/311,813 patent/US5558997A/en not_active Expired - Lifetime
-
1995
- 1995-01-13 AU AU10207/95A patent/AU679293B2/en not_active Ceased
-
1997
- 1997-01-23 GR GR970400017T patent/GR3022368T3/el unknown
-
1998
- 1998-03-12 HK HK98102060A patent/HK1003007A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1020795A (en) | 1995-08-03 |
| IE912278A1 (en) | 1992-01-01 |
| EP0465415A3 (en) | 1992-02-19 |
| DE69124294D1 (de) | 1997-03-06 |
| PT98106B (pt) | 1998-10-30 |
| NZ238733A (en) | 1992-05-26 |
| CA2045875A1 (en) | 1991-12-30 |
| CA2045875C (en) | 2002-11-12 |
| AU679293B2 (en) | 1997-06-26 |
| HK1003007A1 (en) | 1998-09-30 |
| IL98636A0 (en) | 1992-07-15 |
| GR3022368T3 (en) | 1997-04-30 |
| PT98106A (pt) | 1993-06-30 |
| EP0465415B1 (de) | 1997-01-22 |
| DK0465415T3 (da) | 1997-07-14 |
| AU7942791A (en) | 1992-01-02 |
| ATE148162T1 (de) | 1997-02-15 |
| US5558997A (en) | 1996-09-24 |
| ES2099147T3 (es) | 1997-05-16 |
| JPH04229171A (ja) | 1992-08-18 |
| EP0465415A2 (de) | 1992-01-08 |
| DE69124294T2 (de) | 1997-11-13 |
| JP3182696B2 (ja) | 2001-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1339730C (en) | Monoclonal antibiodies and methods for fungal pathogen detection | |
| EP0592127B1 (de) | Immunoassay auf Isothiazolone | |
| WO1983001739A1 (en) | Monoclonal antibodies against brugia malayi | |
| CA2045875C (en) | Monoclonal antibodies to mycosphaerella species | |
| US4803155A (en) | Monoclonal antibodies to Sclerotinia homoeocarpa | |
| EP0292719A2 (de) | Test für gelbe und braune Flecke des Rhizoctonias | |
| US5217871A (en) | Monoclonal antibodies to leptosphaeria nodorum | |
| HK1003007B (en) | Monoclonal antibodies to mycosphaerella species | |
| HK1003006B (en) | Monoclonal antibodies to leptosphaeria | |
| CA2150497C (en) | Inhibitor and anti-inhibitor monoclonal antibodies specific for horseradish peroxidase | |
| CA1339582C (en) | Monoclonal antibodies and methods for diagnosis of phytophthora infection | |
| HU206772B (en) | Method and reagent set for immunological detecting atrazine and atrazine-derivatives and method for obtaining monoclonic antibiotics suitable to said detection | |
| JPH06153979A (ja) | 魚類イリドウイルスに対するモノクローナル抗体並びに該抗体を製造するためのハイブリドーマ及び方法 | |
| WO1983001837A1 (en) | Monoclonal antibodies against schistosoma | |
| Cassano | Murine monoclonal anti-avidin antibodies enhance the sensitivity of avidin-biotin immunoassays and immunohistologic staining | |
| JPH1189568A (ja) | ピリミカーブのハプテン化合物、抗体及び測定方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |