IL97333A - Inhibitors which inhibit catalytic auto-antibodies from catalyzing the cleavage of peptide bonds in substrates and methods of preparation of said inhibitors - Google Patents
Inhibitors which inhibit catalytic auto-antibodies from catalyzing the cleavage of peptide bonds in substrates and methods of preparation of said inhibitorsInfo
- Publication number
- IL97333A IL97333A IL9733391A IL9733391A IL97333A IL 97333 A IL97333 A IL 97333A IL 9733391 A IL9733391 A IL 9733391A IL 9733391 A IL9733391 A IL 9733391A IL 97333 A IL97333 A IL 97333A
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- antibodies
- catalyzing
- cleavage
- substrates
- Prior art date
Links
- 230000003197 catalytic effect Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 238000003776 cleavage reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
- 239000000758 substrate Substances 0.000 title 1
- 102000055135 Vasoactive Intestinal Peptide Human genes 0.000 abstract 2
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 2
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 2
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/486,594 US5194585A (en) | 1989-04-25 | 1990-02-28 | Inhibitors of catalytic antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
IL97333A0 IL97333A0 (en) | 1992-05-25 |
IL97333A true IL97333A (en) | 2000-08-31 |
Family
ID=23932489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9733391A IL97333A (en) | 1990-02-28 | 1991-02-22 | Inhibitors which inhibit catalytic auto-antibodies from catalyzing the cleavage of peptide bonds in substrates and methods of preparation of said inhibitors |
Country Status (10)
Country | Link |
---|---|
US (1) | US5194585A (de) |
EP (1) | EP0517817B1 (de) |
JP (1) | JPH05506016A (de) |
AT (1) | ATE228847T1 (de) |
AU (1) | AU657678B2 (de) |
CA (1) | CA2037199A1 (de) |
DE (1) | DE69133166T2 (de) |
IL (1) | IL97333A (de) |
WO (1) | WO1991012812A1 (de) |
ZA (1) | ZA911292B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5236836A (en) * | 1989-04-25 | 1993-08-17 | Igen, Inc. | Autoantibodies which enhance the rate of a chemical reaction |
US5844102A (en) * | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
US6165799A (en) * | 1996-12-10 | 2000-12-26 | Heska Corporation | Detection of anti-Fc.sub.ε R autoantibodies in asthmatics |
US6235714B1 (en) * | 1998-03-23 | 2001-05-22 | Sudhir Paul | Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses |
JP2004504603A (ja) * | 2000-07-17 | 2004-02-12 | ハンサ メディカル アクチボラゲット | 抗微生物剤 |
EP1950305A1 (de) | 2001-05-09 | 2008-07-30 | Monsanto Technology, LLC | Tyr-A-Gene und ihre Verwendung |
DE60235168D1 (de) | 2001-05-09 | 2010-03-11 | Monsanto Technology Llc | Metabolitentransporter |
WO2008070237A2 (en) * | 2006-09-06 | 2008-06-12 | Siemens Healthcare Diagnostics Inc. | Immunoassay reagents, processes, and kits |
EP2791675B1 (de) * | 2011-12-13 | 2018-04-25 | Baxalta GmbH | Bestimmung von autoantikörpern in geringer leitfähigkeit bedingungen |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4492751A (en) * | 1978-04-10 | 1985-01-08 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing an enzyme substrate as label |
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4493890A (en) * | 1981-03-23 | 1985-01-15 | Miles Laboratories, Inc. | Activated apoglucose oxidase and its use in specific binding assays |
US4661586A (en) * | 1981-11-17 | 1987-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Monoclonal anti-idiotype antibodies |
JPS59232097A (ja) * | 1983-05-16 | 1984-12-26 | Shokuhin Sangyo Center | 鮮度測定方法 |
US4888281A (en) * | 1983-11-29 | 1989-12-19 | Igen, Inc. | Method of catalyzing chemical reactions |
US4659567A (en) * | 1984-09-07 | 1987-04-21 | Scripps Clinic & Research Foundation | Molecules with antibody combining sites that bind to hydrolytic transition states |
US5030717A (en) * | 1986-09-17 | 1991-07-09 | Scripps Clinic And Research Foundation | Antibodies which catalyze hydrolysis of ester bonds |
EP0222876A1 (de) * | 1985-05-07 | 1987-05-27 | California Biotechnology, Inc. | Fusionsproteine für enzymimmunotestverfahren |
US4963355A (en) * | 1986-06-23 | 1990-10-16 | Igen, Inc. | Production of antibody catalysts |
US4792446A (en) * | 1986-06-23 | 1988-12-20 | Igen, Inc. | Production of antibody catalysts |
US4900674A (en) * | 1987-05-28 | 1990-02-13 | Scripps Clinic And Research Foundation | Antibody combining sites that exhibit amide or ester synthase activity |
WO1989001950A1 (en) * | 1987-08-26 | 1989-03-09 | Showa Denko Kabushiki Kaisha | Ethylene/polycyclic monomer copolymer and process for its preparation |
ZA893284B (en) * | 1988-05-04 | 1990-03-28 | Igen Inc | Peptide analogs and their use as haptens to elicit catalytic antibodies |
ES2052027T5 (es) * | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
US5215889A (en) * | 1988-11-18 | 1993-06-01 | The Regents Of The University Of California | Catalytic and reactive polypeptides and methods for their preparation and use |
US5236836A (en) * | 1989-04-25 | 1993-08-17 | Igen, Inc. | Autoantibodies which enhance the rate of a chemical reaction |
-
1990
- 1990-02-28 US US07/486,594 patent/US5194585A/en not_active Expired - Lifetime
-
1991
- 1991-02-21 ZA ZA911292A patent/ZA911292B/xx unknown
- 1991-02-22 IL IL9733391A patent/IL97333A/xx not_active IP Right Cessation
- 1991-02-26 AU AU74660/91A patent/AU657678B2/en not_active Ceased
- 1991-02-26 WO PCT/US1991/001320 patent/WO1991012812A1/en active IP Right Grant
- 1991-02-26 AT AT91905762T patent/ATE228847T1/de not_active IP Right Cessation
- 1991-02-26 DE DE69133166T patent/DE69133166T2/de not_active Expired - Fee Related
- 1991-02-26 EP EP91905762A patent/EP0517817B1/de not_active Expired - Lifetime
- 1991-02-26 JP JP91506071A patent/JPH05506016A/ja active Pending
- 1991-02-27 CA CA002037199A patent/CA2037199A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0517817A1 (de) | 1992-12-16 |
US5194585A (en) | 1993-03-16 |
DE69133166T2 (de) | 2003-11-13 |
JPH05506016A (ja) | 1993-09-02 |
DE69133166D1 (de) | 2003-01-16 |
WO1991012812A1 (en) | 1991-09-05 |
EP0517817A4 (en) | 1993-06-30 |
CA2037199A1 (en) | 1991-08-29 |
AU657678B2 (en) | 1995-03-23 |
IL97333A0 (en) | 1992-05-25 |
ZA911292B (en) | 1992-01-29 |
EP0517817B1 (de) | 2002-12-04 |
ATE228847T1 (de) | 2002-12-15 |
AU7466091A (en) | 1991-09-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |