IL96134A0 - Substituted cycloalkano(b)-dihydroindole-and-indolesulphonamides,their preparation and pharmaceutical compositions containing them - Google Patents
Substituted cycloalkano(b)-dihydroindole-and-indolesulphonamides,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL96134A0 IL96134A0 IL96134A IL9613490A IL96134A0 IL 96134 A0 IL96134 A0 IL 96134A0 IL 96134 A IL96134 A IL 96134A IL 9613490 A IL9613490 A IL 9613490A IL 96134 A0 IL96134 A0 IL 96134A0
- Authority
- IL
- Israel
- Prior art keywords
- dihydroindole
- indolesulphonamides
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula <IMAGE>other radicals, X is aryl, alkyl or CF3, m and Z each is 1,2,3 or 4, n is 0,1 or 2, A is a bond or -NH-, and Y is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso, that in all cases, two of the substituents R1-R4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898924392A GB8924392D0 (en) | 1989-10-30 | 1989-10-30 | Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL96134A0 true IL96134A0 (en) | 1991-07-18 |
Family
ID=10665396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL96134A IL96134A0 (en) | 1989-10-30 | 1990-10-26 | Substituted cycloalkano(b)-dihydroindole-and-indolesulphonamides,their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5039670A (en) |
| EP (1) | EP0425906B1 (en) |
| JP (1) | JPH03151360A (en) |
| KR (1) | KR910007876A (en) |
| CN (1) | CN1051354A (en) |
| AT (1) | ATE102185T1 (en) |
| AU (1) | AU628665B2 (en) |
| CA (1) | CA2028621A1 (en) |
| DE (1) | DE59004764D1 (en) |
| DK (1) | DK0425906T3 (en) |
| ES (1) | ES2062250T3 (en) |
| FI (1) | FI905294A0 (en) |
| GB (1) | GB8924392D0 (en) |
| HU (1) | HUT57190A (en) |
| IE (1) | IE903869A1 (en) |
| IL (1) | IL96134A0 (en) |
| NO (1) | NO904487L (en) |
| NZ (1) | NZ235860A (en) |
| PH (1) | PH27484A (en) |
| PT (1) | PT95728A (en) |
| ZA (1) | ZA908637B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0528762T3 (en) * | 1991-08-15 | 1997-08-25 | Ciba Geigy Ag | N-acyl-N-heterocyclyl or naphthylalkyl amino acids as angiotensin II antagonists |
| DE19506739A1 (en) * | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino] tetrahydrocarbazole propanoic acid ester |
| US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
| AU2003231509A1 (en) * | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
| AU2003231513A1 (en) * | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Pgd2 receptor antagonist |
| AU2004247676A1 (en) * | 2003-06-10 | 2004-12-23 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| CN101203491A (en) * | 2005-06-24 | 2008-06-18 | 伊莱利利公司 | Tetrahydrocarbazole derivatives used as androgen receptor modifier |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
| UA98777C2 (en) * | 2006-11-20 | 2012-06-25 | Эли Лилли Энд Компани | Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators |
| CN101434571B (en) * | 2007-11-13 | 2012-05-30 | 杭州容立医药科技有限公司 | Cycloalkano [1,2-b] indole sulfonic acid amide, and method for synthesizing isomer or salt thereof |
| CN102026974B (en) * | 2008-05-16 | 2013-08-28 | 伊莱利利公司 | Tetrahydrocyclopenta[b]indole androgen receptor modulators |
| MY179356A (en) | 2014-03-17 | 2020-11-05 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
| MX2018003202A (en) | 2015-09-15 | 2018-06-08 | Idorsia Pharmaceuticals Ltd | Crystalline forms. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3514696A1 (en) * | 1985-04-24 | 1986-11-06 | Bayer Ag, 5090 Leverkusen | N-INDOLYLETHYL SULPHONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
| DE3525801A1 (en) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | TERTIA HYDROXYALKYLXANTHINE, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCT CONTAINING IT AND THEIR USE |
| US4808608A (en) * | 1986-01-23 | 1989-02-28 | Merck & Co., Inc. | Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use |
| DE3768097D1 (en) * | 1986-01-23 | 1991-04-04 | Merck Frosst Canada Inc | TETRAHYDROCARBAZOL-1-ALKANIC ACIDS. |
| DE3631824A1 (en) * | 1986-02-21 | 1988-03-31 | Bayer Ag | CYCLOALKANO (1.2-B) INDOL-SULFONAMIDE |
| US4940719A (en) * | 1986-03-27 | 1990-07-10 | Merck Frosst Canada, Inc. | Tetrahydrocarbazole esters, pharmaceutical compositions and use |
| DE3613623A1 (en) * | 1986-04-23 | 1987-10-29 | Bayer Ag | N-DIHYDROINDOLYLETHYL SULFONAMIDE |
-
1989
- 1989-10-30 GB GB898924392A patent/GB8924392D0/en active Pending
-
1990
- 1990-10-05 AU AU63848/90A patent/AU628665B2/en not_active Ceased
- 1990-10-17 US US07/599,321 patent/US5039670A/en not_active Expired - Fee Related
- 1990-10-17 NO NO90904487A patent/NO904487L/en unknown
- 1990-10-18 DK DK90119974.5T patent/DK0425906T3/en active
- 1990-10-18 AT AT90119974T patent/ATE102185T1/en not_active IP Right Cessation
- 1990-10-18 ES ES90119974T patent/ES2062250T3/en not_active Expired - Lifetime
- 1990-10-18 DE DE90119974T patent/DE59004764D1/en not_active Expired - Fee Related
- 1990-10-18 EP EP90119974A patent/EP0425906B1/en not_active Expired - Lifetime
- 1990-10-25 JP JP2286009A patent/JPH03151360A/en active Pending
- 1990-10-26 CA CA002028621A patent/CA2028621A1/en not_active Abandoned
- 1990-10-26 IL IL96134A patent/IL96134A0/en unknown
- 1990-10-26 NZ NZ235860A patent/NZ235860A/en unknown
- 1990-10-26 FI FI905294A patent/FI905294A0/en not_active Application Discontinuation
- 1990-10-26 IE IE386990A patent/IE903869A1/en unknown
- 1990-10-29 KR KR1019900017353A patent/KR910007876A/en not_active Application Discontinuation
- 1990-10-29 ZA ZA908637A patent/ZA908637B/en unknown
- 1990-10-29 HU HU906925A patent/HUT57190A/en unknown
- 1990-10-29 PT PT95728A patent/PT95728A/en not_active Application Discontinuation
- 1990-10-30 CN CN90108726A patent/CN1051354A/en active Pending
- 1990-10-30 PH PH41465A patent/PH27484A/en unknown
-
1991
- 1991-03-28 US US07/678,563 patent/US5096897A/en not_active Expired - Fee Related
-
1993
- 1993-04-05 US US08/042,857 patent/US5374647A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0425906T3 (en) | 1994-04-11 |
| ES2062250T3 (en) | 1994-12-16 |
| AU6384890A (en) | 1991-06-20 |
| NO904487L (en) | 1991-05-02 |
| NZ235860A (en) | 1992-09-25 |
| EP0425906A3 (en) | 1992-01-22 |
| US5374647A (en) | 1994-12-20 |
| KR910007876A (en) | 1991-05-30 |
| HU906925D0 (en) | 1991-05-28 |
| JPH03151360A (en) | 1991-06-27 |
| NO904487D0 (en) | 1990-10-17 |
| CN1051354A (en) | 1991-05-15 |
| PT95728A (en) | 1991-09-13 |
| PH27484A (en) | 1993-07-23 |
| DE59004764D1 (en) | 1994-04-07 |
| HUT57190A (en) | 1991-11-28 |
| CA2028621A1 (en) | 1991-05-01 |
| US5039670A (en) | 1991-08-13 |
| IE903869A1 (en) | 1991-05-08 |
| FI905294A0 (en) | 1990-10-26 |
| ATE102185T1 (en) | 1994-03-15 |
| GB8924392D0 (en) | 1989-12-20 |
| EP0425906B1 (en) | 1994-03-02 |
| AU628665B2 (en) | 1992-09-17 |
| US5096897A (en) | 1992-03-17 |
| ZA908637B (en) | 1991-08-28 |
| EP0425906A2 (en) | 1991-05-08 |
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