IL95368A0 - Method of screening protein inhibitors and activators - Google Patents

Method of screening protein inhibitors and activators

Info

Publication number
IL95368A0
IL95368A0 IL95368A IL9536890A IL95368A0 IL 95368 A0 IL95368 A0 IL 95368A0 IL 95368 A IL95368 A IL 95368A IL 9536890 A IL9536890 A IL 9536890A IL 95368 A0 IL95368 A0 IL 95368A0
Authority
IL
Israel
Prior art keywords
activators
protein inhibitors
screening protein
screening
inhibitors
Prior art date
Application number
IL95368A
Other languages
English (en)
Original Assignee
Gerard M Housey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23549146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL95368(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gerard M Housey filed Critical Gerard M Housey
Publication of IL95368A0 publication Critical patent/IL95368A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL95368A 1989-08-10 1990-08-14 Method of screening protein inhibitors and activators IL95368A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/392,073 US5266464A (en) 1988-02-10 1989-08-10 Method of screening for protein inhibitors and activators

Publications (1)

Publication Number Publication Date
IL95368A0 true IL95368A0 (en) 1991-06-30

Family

ID=23549146

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95368A IL95368A0 (en) 1989-08-10 1990-08-14 Method of screening protein inhibitors and activators

Country Status (7)

Country Link
US (1) US5266464A (fr)
EP (1) EP0486619A4 (fr)
JP (1) JPH05503419A (fr)
AU (1) AU6427190A (fr)
IE (1) IE902899A1 (fr)
IL (1) IL95368A0 (fr)
WO (1) WO1991002085A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688655A (en) * 1988-02-10 1997-11-18 Ict Pharmaceuticals, Inc. Method of screening for protein inhibitors and activators
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
US5519120A (en) * 1989-04-07 1996-05-21 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor antibodies
SE500453C2 (sv) * 1991-10-07 1994-06-27 Karobio Ab Ett in vitro förfarande för utvärdering av en substans effekter
US6051221A (en) * 1993-07-09 2000-04-18 Glaxo Wellcome Inc. BRK protein tyrosine kinase and encoding nucleic acid
CA2185238A1 (fr) * 1994-03-10 1995-09-14 Paul B. Fisher Methodes pour caracteriser des inhibiteurs inductibles d'une progression de transformation
US5597697A (en) * 1994-09-30 1997-01-28 Diamond; Paul Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases
WO1997027212A1 (fr) 1996-01-23 1997-07-31 Rigel Pharmaceuticals, Inc. Methodes de criblage de peptides effecteurs intracellulaires transdominants et de molecules d'arn
US6365344B1 (en) * 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
US6057117A (en) * 1996-04-04 2000-05-02 Chiron Corporation Identification and use of selective inhibitors of glycogen synthase kinase 3
US6004808A (en) * 1996-06-21 1999-12-21 Aurora Biosciences Corporation Promiscuous G-protein compositions and their use
EP0816511B2 (fr) † 1996-06-27 2006-06-14 Clondiag Chip Technologies GmbH Procédé de screening des substances
US6358737B1 (en) * 1996-07-31 2002-03-19 Board Of Regents, The University Of Texas System Osteocyte cell lines
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
CA2277414A1 (fr) 1997-11-07 1999-05-20 Georges Natsoulis Procede de caracterisation de cibles genetiques de remplacement
WO1999050453A1 (fr) * 1998-03-26 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Procede servant a rechercher des inhibiteurs de steroide sulfatase
US6461813B2 (en) 1998-09-21 2002-10-08 Rigel Pharmaceuticals, Inc. Multiparameter FACS assays to detect alterations in cell cycle regulation
US6897031B1 (en) 1998-04-17 2005-05-24 Rigel Pharmaceuticals, Inc. Multiparameter FACS assays to detect alterations in exocytosis
CA2325597C (fr) * 1998-04-17 2010-09-21 Rigel Pharmaceuticals, Inc. Dosages a parametres multiples pour trieurs de cellules par fluorescence servant a detecter des modifications de parametres cellulaires et a cribler des bibliotheques de petites molecules
US8334238B2 (en) 1998-04-17 2012-12-18 Rigel, Inc. Multiparameter FACS assays to detect alterations in cellular parameters and to screen small molecule libraries
US6720139B1 (en) 1999-01-27 2004-04-13 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation in Escherichia coli
US6524797B1 (en) 1999-05-10 2003-02-25 Bernhard O. Palsson Methods of identifying therapeutic compounds in a genetically defined setting
WO2001034810A2 (fr) 1999-11-09 2001-05-17 Elitra Pharmaceuticals, Inc. Genes indispensables a une proliferation microbienne et antisens a cet egard
KR20020086508A (ko) 2000-02-08 2002-11-18 상가모 바이오사이언스 인코포레이티드 약물 발견용 세포
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20030170694A1 (en) * 2001-12-21 2003-09-11 Daniel Wall Stabilized nucleic acids in gene and drug discovery and methods of use
AU2003231827A1 (en) * 2002-05-23 2003-12-12 Invitrogen Corporation Pseudo-tissues and uses thereof
AU2003301348A1 (en) * 2002-10-18 2004-05-04 Wyeth Compositions and methods for diagnosing and treating autoimmune disease
WO2004060316A2 (fr) * 2003-01-02 2004-07-22 Housey Gerard M Modulateurs de l'irs
AU2004203749A1 (en) 2003-01-06 2004-07-22 Wyeth Compositions and methods for diagnosing and treating colon cancers
WO2004070062A2 (fr) * 2003-02-04 2004-08-19 Wyeth Compositions et techniques de diagnostic et de traitement de cancers
WO2004076639A2 (fr) * 2003-02-26 2004-09-10 Wyeth Compositions et methodes destinees a diagnostiquer et traiter des maladies auto-immunes
MXPA05009251A (es) * 2003-03-04 2005-10-19 Wyeth Corp Composiciones y metodos para diagnosticar y tratar asma u otras enfermedades alergicas o inflamatorias.
WO2005001092A2 (fr) * 2003-05-20 2005-01-06 Wyeth Compositions et procedes pour diagnostiquer et traiter le cancer
WO2005020902A2 (fr) * 2003-08-21 2005-03-10 Cytokine Pharmasciences, Inc. Compositions et methodes therapeutiques et diagnostiques du syndrome du colon irritable
US20050164167A1 (en) * 2004-01-28 2005-07-28 Buscher Benjamin A. Method of discovery and development of broad-spectrum antiviral drugs
WO2005115992A1 (fr) 2004-05-23 2005-12-08 Housey Pharmaceuticals, Inc. Modulateurs de theramuteine
US8431110B2 (en) * 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
CN103789389B (zh) * 2005-11-23 2017-01-04 杰勒德·M·豪斯 鉴定、合成、优化和表征蛋白调节剂的化合物和方法
WO2007062213A2 (fr) 2005-11-23 2007-05-31 Housey Pharmaceuticals Inc Composes et procedes d’identification, de synthese, d’optimisation et de creation de profils de modulateurs de proteines
EP1878744A1 (fr) * 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-tag pour des récepteurs de cellules T exprimés en surface, leurs utilisations et méthode de selection de cellules hôtes les exprimant
AU2007353317B2 (en) * 2006-11-15 2012-09-06 Eli Lilly And Company Methods and compositions for treating influenza

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4480038A (en) * 1982-04-30 1984-10-30 E. I. Dupont De Nemours And Company Density separation of protein overproducing bacteria
US4532204A (en) * 1982-07-19 1985-07-30 Massachusetts Institute Of Technology Mutation assays involving blood cells that metabolize toxic substances
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators

Also Published As

Publication number Publication date
AU6427190A (en) 1991-03-11
US5266464A (en) 1993-11-30
EP0486619A4 (en) 1992-08-05
JPH05503419A (ja) 1993-06-10
EP0486619A1 (fr) 1992-05-27
WO1991002085A1 (fr) 1991-02-21
IE902899A1 (en) 1991-02-27

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