IL92512A - OC + 3 complexes and pharmaceutical preparations containing them - Google Patents
OC + 3 complexes and pharmaceutical preparations containing themInfo
- Publication number
- IL92512A IL92512A IL9251289A IL9251289A IL92512A IL 92512 A IL92512 A IL 92512A IL 9251289 A IL9251289 A IL 9251289A IL 9251289 A IL9251289 A IL 9251289A IL 92512 A IL92512 A IL 92512A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- group
- pharmaceutical composition
- alkyl group
- same
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 29
- 150000001875 compounds Chemical class 0.000 claims abstract description 82
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 41
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 29
- 239000001257 hydrogen Substances 0.000 claims abstract description 28
- 239000003446 ligand Substances 0.000 claims abstract description 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 150000004820 halides Chemical class 0.000 claims abstract description 12
- 150000004703 alkoxides Chemical group 0.000 claims abstract description 6
- 239000003937 drug carrier Substances 0.000 claims abstract 9
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- 239000001301 oxygen Substances 0.000 claims description 9
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 239000000460 chlorine Substances 0.000 claims description 5
- 125000001424 substituent group Chemical group 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
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- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 45
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- KGNDCEVUMONOKF-UGPLYTSKSA-N benzyl n-[(2r)-1-[(2s,4r)-2-[[(2s)-6-amino-1-(1,3-benzoxazol-2-yl)-1,1-dihydroxyhexan-2-yl]carbamoyl]-4-[(4-methylphenyl)methoxy]pyrrolidin-1-yl]-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1CO[C@H]1CN(C(=O)[C@@H](CCC=2C=CC=CC=2)NC(=O)OCC=2C=CC=CC=2)[C@H](C(=O)N[C@@H](CCCCN)C(O)(O)C=2OC3=CC=CC=C3N=2)C1 KGNDCEVUMONOKF-UGPLYTSKSA-N 0.000 description 41
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 3
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- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 3
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- 239000000155 melt Substances 0.000 description 1
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
- 229960000582 mepyramine Drugs 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 230000004768 organ dysfunction Effects 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical group O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000005838 radical anions Chemical class 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 102220008708 rs117571555 Human genes 0.000 description 1
- 102220013441 rs12272086 Human genes 0.000 description 1
- 102220082692 rs148315471 Human genes 0.000 description 1
- 102220007446 rs377767446 Human genes 0.000 description 1
- 102220010919 rs397507454 Human genes 0.000 description 1
- 102220304994 rs566363528 Human genes 0.000 description 1
- 102220112756 rs886038414 Human genes 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229960003600 silver sulfadiazine Drugs 0.000 description 1
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/06—Cobalt compounds
- C07F15/065—Cobalt compounds without a metal-carbon linkage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemically Coating (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/279,417 US5049557A (en) | 1986-05-13 | 1988-12-02 | Metallo-organic salt compounds and pharmaceutical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL92512A0 IL92512A0 (en) | 1990-08-31 |
| IL92512A true IL92512A (en) | 1998-12-06 |
Family
ID=23068878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9251289A IL92512A (en) | 1988-12-02 | 1989-12-01 | OC + 3 complexes and pharmaceutical preparations containing them |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5049557A (de) |
| EP (1) | EP0481994B1 (de) |
| JP (1) | JPH04507398A (de) |
| AT (1) | ATE178608T1 (de) |
| AU (1) | AU637340B2 (de) |
| CA (1) | CA2004534C (de) |
| DE (1) | DE68928968T2 (de) |
| IL (1) | IL92512A (de) |
| WO (1) | WO1990006119A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756491A (en) * | 1986-05-13 | 1998-05-26 | Chai-Tech Corporation | Antiviral cobalt-organic compounds |
| US5258403A (en) * | 1986-05-13 | 1993-11-02 | Chai-Tech Corporation | Metallo-organic salt compounds and pharmaceutical uses thereof |
| US5106841A (en) * | 1986-05-13 | 1992-04-21 | Chai-Tech Corporation | Antiviral compositions and method for their use |
| AU5871494A (en) * | 1992-12-15 | 1994-07-04 | Redox Pharmaceutical Corporation | Antiviral compositions and method for their use |
| US6008190A (en) * | 1994-12-15 | 1999-12-28 | California Institute Of Technology | Cobalt Schiff base compounds |
| DE69942976D1 (de) * | 1998-05-06 | 2011-01-05 | Children S Hospital Res Foundation | Verfahren zur hsv-prophylaxe |
| CA2343824A1 (en) * | 1998-06-11 | 1999-12-16 | Redox Pharmaceutical Corporation | Method of hiv and hpv prophylaxis |
| US6376483B1 (en) | 1999-05-27 | 2002-04-23 | Miravant Pharmaceuticals, Inc. | Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production |
| WO2001005396A1 (en) * | 1999-07-16 | 2001-01-25 | The Trustees Of Columbia University In The City Of New York | Use of cobalt chelates for treating or preventing virus infection |
| US6756368B1 (en) | 1999-07-16 | 2004-06-29 | The Trustees Of Columbia University In The City Of New York | Use of cobalt chelates for treating or preventing virus infection |
| EP1284726A4 (de) * | 2000-03-10 | 2005-07-20 | Childrens Hosp Medical Center | Methode zur prophylaktischen behandlung einer chlamydieninfektion |
| US6780856B2 (en) * | 2000-04-07 | 2004-08-24 | California Institute Of Technology | Towards increased shelf life for cobalt(III) schiff base complexes |
| AU2004249292A1 (en) * | 2003-06-20 | 2004-12-29 | Redox Pharmaceutical Corporation | Microbicidal, prophylactic and therapeutic effect of CTC-96 on papilloma viruses |
| JP4961700B2 (ja) | 2005-09-08 | 2012-06-27 | Ｊｎｃ株式会社 | 末端が水素であるナフタレン誘導体、この誘導体を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子 |
| US20100298415A1 (en) * | 2009-03-23 | 2010-11-25 | Northwestern University | Targeted schiff base complexes |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3420865A (en) * | 1966-05-12 | 1969-01-07 | Colgate Palmolive Co | Novel carbocyclic ferrocenes |
| DE2527158A1 (de) * | 1975-06-18 | 1976-12-23 | Herz Eberhard | Arzneimittel zur behandlung von infektionskrankheiten und von nicht nachweisbar durch mikroorganismen ausgeloeste entzuendungen in der human- und veterinaermedizin |
| CA1218600A (en) * | 1982-12-06 | 1987-03-03 | Gerald L. Maurer | Methods and compositions for treating inflammation or arthritis |
| DE3404443A1 (de) * | 1984-02-08 | 1985-08-08 | Hartmut Prof. Dr. 1000 Berlin Köpf | Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung |
| US4514522A (en) * | 1984-07-27 | 1985-04-30 | University Patents, Inc. | Oxygen sorbent |
| US4727068A (en) * | 1985-10-23 | 1988-02-23 | Johnson Matthey, Inc. | Radiosensitization by cobalt and Fe(III) complexes |
| IL82376A (en) * | 1986-05-13 | 1991-06-10 | Chai Tech Corp | Pharmaceutical composition for the treatment of inflammatory conditions |
| US4735634A (en) * | 1986-08-28 | 1988-04-05 | Air Products And Chemicals, Inc. | Pillared cobalt complexes for oxygen separation |
| HU198913B (en) * | 1987-09-03 | 1989-12-28 | Pliva Pharm & Chem Works | Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components |
| US4950790A (en) * | 1988-11-14 | 1990-08-21 | Air Products And Chemicals, Inc. | Volatile fluorinated β-ketoimines and associated metal complexes |
| CA2004639A1 (en) * | 1988-12-12 | 1990-06-12 | John A. T. Norman | Fluorinated beta-ketoimines and beta-ketoiminato metal complexes |
-
1988
- 1988-12-02 US US07/279,417 patent/US5049557A/en not_active Expired - Lifetime
-
1989
- 1989-12-01 IL IL9251289A patent/IL92512A/en not_active IP Right Cessation
- 1989-12-04 AT AT90900578T patent/ATE178608T1/de not_active IP Right Cessation
- 1989-12-04 WO PCT/US1989/005476 patent/WO1990006119A1/en not_active Ceased
- 1989-12-04 AU AU47483/90A patent/AU637340B2/en not_active Ceased
- 1989-12-04 DE DE68928968T patent/DE68928968T2/de not_active Expired - Lifetime
- 1989-12-04 CA CA002004534A patent/CA2004534C/en not_active Expired - Lifetime
- 1989-12-04 EP EP90900578A patent/EP0481994B1/de not_active Expired - Lifetime
- 1989-12-04 JP JP2500899A patent/JPH04507398A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2004534C (en) | 1995-12-26 |
| EP0481994A4 (en) | 1993-03-03 |
| ATE178608T1 (de) | 1999-04-15 |
| US5049557A (en) | 1991-09-17 |
| IL92512A0 (en) | 1990-08-31 |
| EP0481994A1 (de) | 1992-04-29 |
| CA2004534A1 (en) | 1990-06-02 |
| AU4748390A (en) | 1990-06-26 |
| EP0481994B1 (de) | 1999-04-07 |
| DE68928968D1 (de) | 1999-05-12 |
| JPH04507398A (ja) | 1992-12-24 |
| WO1990006119A1 (en) | 1990-06-14 |
| AU637340B2 (en) | 1993-05-27 |
| DE68928968T2 (de) | 2000-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |