IL89922A - Preparations for the control of diabetes Container plant extract and methods for their preparation - Google Patents
Preparations for the control of diabetes Container plant extract and methods for their preparationInfo
- Publication number
- IL89922A IL89922A IL8992289A IL8992289A IL89922A IL 89922 A IL89922 A IL 89922A IL 8992289 A IL8992289 A IL 8992289A IL 8992289 A IL8992289 A IL 8992289A IL 89922 A IL89922 A IL 89922A
- Authority
- IL
- Israel
- Prior art keywords
- plant
- hexachlymus
- edulis
- composition
- polar solvent
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 22
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title description 4
- 239000000419 plant extract Substances 0.000 title description 2
- 239000000284 extract Substances 0.000 claims abstract description 41
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 35
- 239000008103 glucose Substances 0.000 claims abstract description 35
- 239000002798 polar solvent Substances 0.000 claims abstract description 31
- 239000008280 blood Substances 0.000 claims abstract description 30
- 210000004369 blood Anatomy 0.000 claims abstract description 30
- 230000002218 hypoglycaemic effect Effects 0.000 claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000003085 diluting agent Substances 0.000 claims description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 7
- 230000002879 macerating effect Effects 0.000 claims description 6
- 239000002504 physiological saline solution Substances 0.000 claims description 5
- 206010020710 Hyperphagia Diseases 0.000 claims description 3
- 208000004880 Polyuria Diseases 0.000 claims description 3
- 206010036067 polydipsia Diseases 0.000 claims description 3
- 208000022530 polyphagia Diseases 0.000 claims description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract description 17
- 241000196324 Embryophyta Species 0.000 description 25
- RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 description 9
- 229960001761 chlorpropamide Drugs 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 241000894007 species Species 0.000 description 8
- 241000700159 Rattus Species 0.000 description 6
- 239000000469 ethanolic extract Substances 0.000 description 6
- 235000013399 edible fruits Nutrition 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 239000003538 oral antidiabetic agent Substances 0.000 description 5
- 229940127209 oral hypoglycaemic agent Drugs 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241000023318 Eugenia myrcianthes Species 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 4
- 239000003472 antidiabetic agent Substances 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 229940126904 hypoglycaemic agent Drugs 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 229940098465 tincture Drugs 0.000 description 4
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229940100389 Sulfonylurea Drugs 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000004153 islets of langerhan Anatomy 0.000 description 2
- 238000002803 maceration Methods 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 240000001829 Catharanthus roseus Species 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 241000920033 Eugenes Species 0.000 description 1
- 241000208253 Gymnema sylvestre Species 0.000 description 1
- 240000001194 Heliotropium europaeum Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 241000687607 Natalis Species 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 229920002396 Polyurea Polymers 0.000 description 1
- 244000172730 Rubus fruticosus Species 0.000 description 1
- 235000017848 Rubus fruticosus Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 235000021029 blackberry Nutrition 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- KNZUAMRYQXIWSR-RUAUHYFQSA-N curan Chemical compound C1=CC=C2[C@@]3([C@@H]4C5)CCN4C[C@@H](CC)[C@H]5[C@@H](C)[C@@H]3NC2=C1 KNZUAMRYQXIWSR-RUAUHYFQSA-N 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000021038 drupes Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Ceramics (AREA)
- Chemically Coating (AREA)
- Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18042088A | 1988-04-12 | 1988-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL89922A0 IL89922A0 (en) | 1989-12-15 |
| IL89922A true IL89922A (en) | 1994-10-07 |
Family
ID=22660398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8992289A IL89922A (en) | 1988-04-12 | 1989-04-11 | Preparations for the control of diabetes Container plant extract and methods for their preparation |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0337398B1 (de) |
| JP (1) | JPH03504720A (de) |
| KR (1) | KR900700119A (de) |
| AT (1) | ATE79760T1 (de) |
| AU (1) | AU3411189A (de) |
| CA (1) | CA1334738C (de) |
| DE (1) | DE68902569T2 (de) |
| IL (1) | IL89922A (de) |
| WO (1) | WO1989009608A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002094299A1 (fr) * | 2001-05-18 | 2002-11-28 | Gbodossou Erick Vidjin Agnih | Extraits de plantes medicinales dans le traitement des maladies diabetiques |
| CN115006499A (zh) * | 2017-09-22 | 2022-09-06 | 甄挺 | 预防和治疗ii型糖尿病及其并发症的中药组合物和平糖丸 |
-
1989
- 1989-04-07 JP JP1504386A patent/JPH03504720A/ja active Pending
- 1989-04-07 AU AU34111/89A patent/AU3411189A/en not_active Abandoned
- 1989-04-07 KR KR1019890702303A patent/KR900700119A/ko not_active Withdrawn
- 1989-04-07 WO PCT/US1989/001455 patent/WO1989009608A1/en not_active Ceased
- 1989-04-11 DE DE8989106422T patent/DE68902569T2/de not_active Expired - Lifetime
- 1989-04-11 AT AT89106422T patent/ATE79760T1/de not_active IP Right Cessation
- 1989-04-11 IL IL8992289A patent/IL89922A/en not_active IP Right Cessation
- 1989-04-11 EP EP89106422A patent/EP0337398B1/de not_active Expired - Lifetime
- 1989-04-12 CA CA000596450A patent/CA1334738C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE68902569D1 (de) | 1992-10-01 |
| IL89922A0 (en) | 1989-12-15 |
| EP0337398A1 (de) | 1989-10-18 |
| JPH03504720A (ja) | 1991-10-17 |
| CA1334738C (en) | 1995-03-14 |
| AU3411189A (en) | 1989-11-03 |
| KR900700119A (ko) | 1990-08-11 |
| WO1989009608A1 (en) | 1989-10-19 |
| EP0337398B1 (de) | 1992-08-26 |
| ATE79760T1 (de) | 1992-09-15 |
| DE68902569T2 (de) | 1992-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH1 | Patent not in force |