IL87707A - Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof - Google Patents

Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof

Info

Publication number
IL87707A
IL87707A IL8770788A IL8770788A IL87707A IL 87707 A IL87707 A IL 87707A IL 8770788 A IL8770788 A IL 8770788A IL 8770788 A IL8770788 A IL 8770788A IL 87707 A IL87707 A IL 87707A
Authority
IL
Israel
Prior art keywords
hemoglobin
blood substitute
blood
stroma
based blood
Prior art date
Application number
IL8770788A
Other languages
English (en)
Other versions
IL87707A0 (en
Inventor
Ehud Ilan
Noah Lotan
Tova Cohen
Shmuel Sideman
Original Assignee
Technion Inst For Research And
Mini Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Inst For Research And, Mini Defence filed Critical Technion Inst For Research And
Priority to IL8770788A priority Critical patent/IL87707A/en
Publication of IL87707A0 publication Critical patent/IL87707A0/xx
Priority to JP1230593A priority patent/JPH02115200A/ja
Priority to AT89309169T priority patent/ATE99950T1/de
Priority to DE68912259T priority patent/DE68912259T2/de
Priority to EP89309169A priority patent/EP0361719B1/fr
Publication of IL87707A publication Critical patent/IL87707A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL8770788A 1988-09-08 1988-09-08 Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof IL87707A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL8770788A IL87707A (en) 1988-09-08 1988-09-08 Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof
JP1230593A JPH02115200A (ja) 1988-09-08 1989-09-07 ヘモグロビン系血液代用物質およびその調製方法
AT89309169T ATE99950T1 (de) 1988-09-08 1989-09-08 Blutersatzmittel mit haemoglobinen als grundstoff und verfahren zur herstellung.
DE68912259T DE68912259T2 (de) 1988-09-08 1989-09-08 Blutersatzmittel mit Hämoglobinen als Grundstoff und Verfahren zur Herstellung.
EP89309169A EP0361719B1 (fr) 1988-09-08 1989-09-08 Substitut du sang à base d'hémoglobine et méthode de préparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL8770788A IL87707A (en) 1988-09-08 1988-09-08 Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof

Publications (2)

Publication Number Publication Date
IL87707A0 IL87707A0 (en) 1989-02-28
IL87707A true IL87707A (en) 1994-06-24

Family

ID=11059237

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8770788A IL87707A (en) 1988-09-08 1988-09-08 Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof

Country Status (5)

Country Link
EP (1) EP0361719B1 (fr)
JP (1) JPH02115200A (fr)
AT (1) ATE99950T1 (fr)
DE (1) DE68912259T2 (fr)
IL (1) IL87707A (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
NL8901174A (nl) * 1989-05-10 1990-12-03 Het Hoofd Van De Afdeling Mili Hemoglobine-preparaat en gebruik daarvan.
EP0459788A3 (en) * 1990-06-01 1992-01-22 Common Services Agency Modified proteins and methods of producing same
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
WO1992003153A1 (fr) * 1990-08-17 1992-03-05 Baxter International Inc. Composition a base d'hemoglobine-oligomere et procede de preparation
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5900477A (en) * 1992-01-30 1999-05-04 Baxter International, Inc. Use of hemoglobin in the treatment of hemorrhagic shock
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6458762B1 (en) 1994-03-28 2002-10-01 Baxter International, Inc. Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
JPH08511279A (ja) * 1994-03-28 1996-11-26 バクスター、インターナショナル、インコーポレイテッド 血管閉鎖の治療におけるヘモグロビンの治療的使用
WO1996032130A1 (fr) * 1995-04-10 1996-10-17 Baxter International Inc. Utilisation d'hemoglobine reticulee dans le traitement des hemorragies sous-arachnoidiennes
US5733869A (en) * 1995-10-06 1998-03-31 Baxter International, Inc. Therapeutic administration of hemoglobin in cardiac arrest
WO1997033914A1 (fr) * 1996-03-15 1997-09-18 Staat Der Nederlanden, De Minister Van Defensie Procedes de productions de preparations d'hemoglobine et preparations ainsi obtenues
DE69831248T2 (de) 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6670323B1 (en) 1999-11-12 2003-12-30 Baxter International, Inc. Reduced side-effect hemoglobin compositions
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
ES2032802T5 (es) * 1986-11-10 2004-01-16 Biopure Corporation Sucedaneo de sangre semisintetico extrapuro.

Also Published As

Publication number Publication date
JPH02115200A (ja) 1990-04-27
DE68912259D1 (de) 1994-02-24
EP0361719B1 (fr) 1994-01-12
ATE99950T1 (de) 1994-01-15
IL87707A0 (en) 1989-02-28
EP0361719A1 (fr) 1990-04-04
DE68912259T2 (de) 1994-05-26

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Legal Events

Date Code Title Description
RH Patent void