IL86327A - Process for recovering microbially produced interleukin-2 - Google Patents

Process for recovering microbially produced interleukin-2

Info

Publication number
IL86327A
IL86327A IL86327A IL8632788A IL86327A IL 86327 A IL86327 A IL 86327A IL 86327 A IL86327 A IL 86327A IL 8632788 A IL8632788 A IL 8632788A IL 86327 A IL86327 A IL 86327A
Authority
IL
Israel
Prior art keywords
ril
oxidized
solution
purified
microbially produced
Prior art date
Application number
IL86327A
Other languages
English (en)
Other versions
IL86327A0 (en
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of IL86327A0 publication Critical patent/IL86327A0/xx
Publication of IL86327A publication Critical patent/IL86327A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL86327A 1987-05-11 1988-05-10 Process for recovering microbially produced interleukin-2 IL86327A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4840587A 1987-05-11 1987-05-11
US07/167,145 US4931543A (en) 1987-05-11 1988-03-25 Process for recovering microbially produced interleukin-2

Publications (2)

Publication Number Publication Date
IL86327A0 IL86327A0 (en) 1988-11-15
IL86327A true IL86327A (en) 1992-12-01

Family

ID=26726086

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86327A IL86327A (en) 1987-05-11 1988-05-10 Process for recovering microbially produced interleukin-2

Country Status (9)

Country Link
US (1) US4931543A (de)
EP (1) EP0357645B1 (de)
AT (1) ATE152730T1 (de)
AU (1) AU619185B2 (de)
CA (1) CA1335925C (de)
DE (1) DE3855899T2 (de)
IE (1) IE80433B1 (de)
IL (1) IL86327A (de)
WO (1) WO1988008850A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
US5248769A (en) * 1985-06-26 1993-09-28 Cetus Oncology Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5047504A (en) * 1987-04-28 1991-09-10 Amgen, Inc. Method for purifying granulocyte-macrophage colony stimulating factor
ATE156491T1 (de) * 1987-05-11 1997-08-15 Chiron Corp Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
US5364762A (en) * 1990-03-21 1994-11-15 Board Of Trustees Of The Leland Stanford Junior University Major histocompatibility complex (MHC) molecules
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein
FR2684878B1 (fr) * 1991-12-12 1994-02-11 Roussel Uclaf Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.
AU4665193A (en) * 1992-07-02 1994-01-31 Pitman-Moore, Inc. A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
US5605691A (en) * 1992-09-17 1997-02-25 Ophidian Pharmaceuticals, Inc. Immunologically active proteins from inclusion bodies
US5714371A (en) * 1995-05-12 1998-02-03 Schering Corporation Method for refolding insoluble aggregates of hepatitis C virus protease
DE19836559A1 (de) 1998-08-12 2000-03-23 Antigen Gmbh Gefäß zur Entnahme von Blut
HUP0203133A3 (en) 1999-10-04 2005-07-28 Chiron Corp Emeryville Stabilized liquid polypeptide-containing pharmaceutical compositions
EP1267927A1 (de) * 2000-03-24 2003-01-02 Chiron Corporation Verfahren zur behandlung von lymphomen vom typ non-hodgkin unter verwendung einer kombination eines antikörpers gegen cd20 und interleukin-2
EP1935431A3 (de) 2000-05-15 2008-08-13 Health Research, Inc. Krebsbehandlungen unter Verwendung einer Kombination aus einem HER2-Antikörper und Interleukin-2
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
BR0210772A (pt) * 2001-07-02 2004-07-20 Aimsco Ltd Usos de um anticorpo anti-hla, e de uma composição de soro de cabra
US6924124B1 (en) * 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
AU2004204720B2 (en) 2003-01-08 2009-08-06 Novartis Vaccines And Diagnostics, Inc. Stabilized aqueous compositions comprising tissue factor pathway inhibitor (TFPI) or tissue factor pathway inhibitor variant
ATE473016T1 (de) 2003-11-04 2010-07-15 Novartis Vaccines & Diagnostic Verfahren zur behandlung von krebs mit expression des cd40-antigens
EP1846020B1 (de) * 2005-01-27 2013-08-21 Novartis Vaccines and Diagnostics, Inc. Verfahren zur behandlung von nierenzellenkarzinom
US20060251617A1 (en) * 2005-02-15 2006-11-09 Chiron Corporation Methods for treating lymphomas
US9428567B2 (en) 2010-12-22 2016-08-30 The Board Of Trustees Of The Leland Stanford Junior University Antagonists of interleukin-2 receptor
CA2925421C (en) 2013-09-24 2023-08-29 Medicenna Therapeutics, Inc. Interleukin-2 fusion proteins and uses thereof
WO2015164815A1 (en) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
JP7433051B2 (ja) 2017-06-19 2024-02-19 メディシナ セラピューティクス インコーポレイテッド Ｉｌ－２スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法
PH12020550661A1 (en) 2017-11-21 2021-04-19 Univ Leland Stanford Junior Partial agonists of interleukin-2
EP4090674A4 (de) 2020-01-14 2024-01-24 Synthekine, Inc. Vorgespannte il2-muteins-verfahren und -zusammensetzungen

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4464295A (en) * 1983-08-17 1984-08-07 The United States Of America As Represented By The Secretary Of Agriculture Simple and rapid method for extraction of proteins from bacteria
US4476049A (en) * 1983-09-20 1984-10-09 Hoffmann-La Roche Inc. Method for the extraction of immune interferon
JPS60115528A (ja) * 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
DK174501B1 (da) * 1983-12-23 2003-04-28 Hoffmann La Roche Fremgangsmåde til fremstilling af interleukin-2
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4604377A (en) * 1984-03-28 1986-08-05 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
FR2569130B1 (fr) * 1984-08-20 1989-09-08 Langreney Francois Procede et dispositif de cristallisation continue, notamment du saccharose
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4659568A (en) * 1985-02-27 1987-04-21 American Cyanamid Company Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
US4873312A (en) * 1985-04-25 1989-10-10 Amgen Method for purifying interferon and composition of matter produced thereby
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
EP0208539A3 (de) * 1985-07-11 1988-08-03 Repligen Corporation In Falten gelegte Proteine, durch Disulfid gebunden
US4766224A (en) * 1985-08-19 1988-08-23 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4904602A (en) * 1985-11-27 1990-02-27 Repligen Corporation Thioredoxin shufflease and use thereof
AU597924B2 (en) * 1985-12-11 1990-06-14 Natinco Nv Solubilization of protein aggregates
CA1292686C (en) * 1986-10-27 1991-12-03 Ze'ev Shaked Pharmaceutical compositions of recombinant interleukin-2 and formulation process
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
ATE156491T1 (de) * 1987-05-11 1997-08-15 Chiron Corp Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
US4801691A (en) * 1987-05-15 1989-01-31 International Minerals & Chemical Corp. Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions

Also Published As

Publication number Publication date
EP0357645A1 (de) 1990-03-14
EP0357645B1 (de) 1997-05-07
AU619185B2 (en) 1992-01-23
AU1681288A (en) 1988-12-06
ATE152730T1 (de) 1997-05-15
WO1988008850A1 (en) 1988-11-17
CA1335925C (en) 1995-06-13
US4931543A (en) 1990-06-05
DE3855899D1 (de) 1997-06-12
DE3855899T2 (de) 1997-09-18
IL86327A0 (en) 1988-11-15
IE80433B1 (en) 1998-07-15
IE881409L (en) 1988-11-11

Similar Documents

Publication Publication Date Title
IE881409L (en) Recovering microbially produced interleukin-2
AU585131B2 (en) New aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having antipsychotic properties
PH21012A (en) Process for recovering microbially produced interleukin-2 and purified recombinant interleukin 2 compositions
ES8502409A1 (es) Procedimiento para la purificacion de aguas residuales
DE3574125D1 (en) Method of purifying waste water
EP0111389A3 (de) Wesentlich sauberes Schweinewachstumshormon, DNS-Sequenzen dafür und Expressionsvektoren und transfektierte Mikroorganismen zur Herstellung von Schweinewachstumshormon
AU575304B2 (en) Removal of impurities from human leukocyte interferon
AU8210987A (en) N-alkyl and n-alkenyl aspartic acids as collectors for the flotation of non-sulfidic ores
AU1627988A (en) Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
AU589569B2 (en) Method for recovering purified growth hormones from genetically engineered microorganisms
EP0248618A3 (en) Isolation of bioactive, monomeric growth hormone
ES8601711A1 (es) Procedimiento para la separacion de oxo-alcoholes de cadena lineal de mezclas de oxo-alcoholes de cadena lineal y cadenaramificada
AU2284188A (en) Improved process for recovering microbially produced interferon-beta
WO1987000204A3 (en) Purification of somatotropin from transformed microorganisms
AU596688B2 (en) Process for the production of low carbon silicon
ES8504473A1 (es) Procedimiento para retirar el dioxido de azufre de los gases de escape
FR2621905B1 (de)
JPS6475096A (en) Removal method for tetramethylammonium compound
RO100030A2 (ro) Procedeu de obtinere a (r.s.) -3-(2,3-epoxipropoxi)-4-(n-morfolino)-1,2,5-tiadiazolului
RO100029A2 (ro) Procedeu de obtinere a derivatului sodat al 3-hidroxi-4-(n-morfolino)-1,2,5-tiaddiazolului

Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired