IL74902A - Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors - Google Patents

Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors

Info

Publication number
IL74902A
IL74902A IL74902A IL7490285A IL74902A IL 74902 A IL74902 A IL 74902A IL 74902 A IL74902 A IL 74902A IL 7490285 A IL7490285 A IL 7490285A IL 74902 A IL74902 A IL 74902A
Authority
IL
Israel
Prior art keywords
particle
treatment
phosphonic acid
organic amine
acid complexes
Prior art date
Application number
IL74902A
Other languages
English (en)
Other versions
IL74902A0 (en
Inventor
Simon Jaime
A Volkert Wynn
A Wilson David
E Troutner David
F Goeckeler William
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of IL74902A0 publication Critical patent/IL74902A0/xx
Publication of IL74902A publication Critical patent/IL74902A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL74902A 1984-06-04 1985-04-15 Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors IL74902A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61698584A 1984-06-04 1984-06-04

Publications (2)

Publication Number Publication Date
IL74902A0 IL74902A0 (en) 1985-07-31
IL74902A true IL74902A (en) 1990-12-23

Family

ID=24471820

Family Applications (1)

Application Number Title Priority Date Filing Date
IL74902A IL74902A (en) 1984-06-04 1985-04-15 Organic amine phosphonic acid complexes with particle-emitting radionuclides for the treatment of calcific tumors

Country Status (10)

Country Link
EP (1) EP0164843B1 (fi)
JP (2) JPH0655681B2 (fi)
AU (1) AU563671B2 (fi)
CA (1) CA1243603A (fi)
DE (2) DE164843T1 (fi)
HK (1) HK146895A (fi)
IL (1) IL74902A (fi)
NL (1) NL980021I2 (fi)
NZ (1) NZ211808A (fi)
ZA (1) ZA852799B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515767A (en) * 1983-06-20 1985-05-07 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
EP0225409A1 (en) * 1985-12-02 1987-06-16 The Dow Chemical Company Organic amine phosphonic acid complexes for the treatment of calcific tumors
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
NZ222304A (en) * 1987-05-18 1990-10-26 Dow Chemical Co Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
EP1191948A2 (en) 1999-06-11 2002-04-03 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE19953636A1 (de) * 1999-11-09 2001-05-23 Karlsruhe Forschzent Radioaktive Materialien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2543349C2 (de) * 1975-09-29 1984-05-10 Henkel KGaA, 4000 Düsseldorf Preaparate zur herstellung von99m technetium-radiagnostica
CA1078731A (en) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4504463A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4508704A (en) * 1984-02-27 1985-04-02 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of bicycloheptane bis(alkylamines)

Also Published As

Publication number Publication date
AU563671B2 (en) 1987-07-16
NL980021I1 (nl) 1998-09-01
EP0164843A3 (en) 1987-09-23
HK146895A (en) 1995-09-22
JPH0655681B2 (ja) 1994-07-27
JPH0448799B2 (fi) 1992-08-07
EP0164843B1 (en) 1991-06-19
NL980021I2 (nl) 1999-02-01
JPS62132892A (ja) 1987-06-16
ZA852799B (en) 1986-12-30
IL74902A0 (en) 1985-07-31
DE3583257D1 (de) 1991-07-25
EP0164843A2 (en) 1985-12-18
DE164843T1 (de) 1989-12-07
CA1243603A (en) 1988-10-25
NZ211808A (en) 1989-01-06
AU4122985A (en) 1985-12-12
JPS6122029A (ja) 1986-01-30

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