IL68909A - 5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo(1,2 a)pyrrole-1-carboxylic acids and derivatives thereof;their production and pharmaceutical compositions containing them - Google Patents

5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo(1,2 a)pyrrole-1-carboxylic acids and derivatives thereof;their production and pharmaceutical compositions containing them

Info

Publication number
IL68909A
IL68909A IL68909A IL6890983A IL68909A IL 68909 A IL68909 A IL 68909A IL 68909 A IL68909 A IL 68909A IL 6890983 A IL6890983 A IL 6890983A IL 68909 A IL68909 A IL 68909A
Authority
IL
Israel
Prior art keywords
sub
alkylthio
aroyl
pyrrolo
pyrrole
Prior art date
Application number
IL68909A
Other languages
English (en)
Other versions
IL68909A0 (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IL68909A0 publication Critical patent/IL68909A0/xx
Priority to IL78159A priority Critical patent/IL78159A0/xx
Publication of IL68909A publication Critical patent/IL68909A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL68909A 1982-06-08 1983-06-07 5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo(1,2 a)pyrrole-1-carboxylic acids and derivatives thereof;their production and pharmaceutical compositions containing them IL68909A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL78159A IL78159A0 (en) 1982-06-08 1986-03-14 5-aroyl-6-alkylthio-,-alkylsulfinyl-and-alkylsulfonyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carbonitriles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/386,174 US4612325A (en) 1982-06-08 1982-06-08 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories

Publications (2)

Publication Number Publication Date
IL68909A0 IL68909A0 (en) 1983-10-31
IL68909A true IL68909A (en) 1987-02-27

Family

ID=23524483

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68909A IL68909A (en) 1982-06-08 1983-06-07 5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo(1,2 a)pyrrole-1-carboxylic acids and derivatives thereof;their production and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US4612325A (es)
EP (1) EP0096583B1 (es)
JP (1) JPS595190A (es)
KR (1) KR880000393B1 (es)
AT (1) ATE29497T1 (es)
AU (1) AU556295B2 (es)
CA (1) CA1200244A (es)
DE (1) DE3373474D1 (es)
DK (1) DK260483A (es)
ES (4) ES523063A0 (es)
FI (1) FI77245C (es)
HU (1) HU190106B (es)
IL (1) IL68909A (es)
NO (1) NO162386B (es)
NZ (1) NZ204487A (es)
ZA (1) ZA834137B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560699A (en) * 1983-01-17 1985-12-24 Syntex (U.S.A.) Inc. 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents

Also Published As

Publication number Publication date
NO162386B (no) 1989-09-11
US4612325A (en) 1986-09-16
KR880000393B1 (ko) 1988-03-21
ES8600295A1 (es) 1985-10-16
FI77245B (fi) 1988-10-31
FI832045L (fi) 1983-12-09
FI832045A0 (fi) 1983-06-07
EP0096583B1 (en) 1987-09-09
ATE29497T1 (de) 1987-09-15
ES537694A0 (es) 1985-10-16
ES537695A0 (es) 1985-10-16
ES8600296A1 (es) 1985-10-16
CA1200244A (en) 1986-02-04
FI77245C (fi) 1989-02-10
ES8502999A1 (es) 1985-02-16
JPS595190A (ja) 1984-01-12
DE3373474D1 (en) 1987-10-15
NO832053L (no) 1983-12-09
ZA834137B (en) 1985-01-30
ES8600294A1 (es) 1985-10-16
ES537696A0 (es) 1985-10-16
DK260483D0 (da) 1983-06-07
KR840005144A (ko) 1984-11-03
AU1546483A (en) 1983-12-15
AU556295B2 (en) 1986-10-30
ES523063A0 (es) 1985-02-16
DK260483A (da) 1983-12-09
EP0096583A3 (en) 1985-05-02
NZ204487A (en) 1986-06-11
IL68909A0 (en) 1983-10-31
HU190106B (en) 1986-08-28
EP0096583A2 (en) 1983-12-21

Similar Documents

Publication Publication Date Title
CA1260471C (es)
JPS56142259A (en) Beta-lactam compound and its preparation
AU671305B2 (en) Pyrazolo(4,3-c)pyridines, a process for their preparation and their use as serotonin reuptake inhibitors
HUT62295A (en) Method for producing heteroaryl-8-aza-bicyclo-/3.2.1/octanes and pharmaceutical preparatives containing them
AU663363B2 (en) (1H-indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments
IL68909A (en) 5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo(1,2 a)pyrrole-1-carboxylic acids and derivatives thereof;their production and pharmaceutical compositions containing them
DE3666588D1 (en) Spiroûbenzofuran-2(3h), 1'cycloheptane¨s, a process and intermediates for their preparation and their use as medicaments
EP0167922A3 (en) Pyrrolo û1,2-b¨ û1,2,5¨ triazepines, a process and intermediates for their preparation and their use as medicaments
DE3461281D1 (en) +/- 2-((3,4-methylenedioxy)phenethyl)-5-((3-carboxamido-4-hydroxy)-alpha-hydroxybenzyl)pyrrolidines, pharmaceutical compositions containing them, process for their production and intermediates therefor
ES514783A0 (es) Un procedimiento para preparar acido 1,4-dimetil-i-(1-metil-5-metil-tiopirrol-2-oil) pirrol-2-acetico y sus analogos,dotados de propiedades antiinflamatorias.
HU893309D0 (en) Process for producing antagonists of alpha-adrenergic receptor and pharmaceutical preparatives containing these compounds
JPS6470488A (en) Novel 3-aroyl-6,7-dihydro-5h-pyrrolo(1,2-c)imidazole-7-carboxylic acid derivative
HU9302750D0 (en) 1,5,6,7-tetra hydro-4h-indasole-4-on, new pharmaceutical compositions containing said compounds and process for producing them
PT84005A (en) 6h-isoxazol]3,4-d"pyrazolo]3,4-b"pyridines a process and intermediates for their preparation and their use as medicaments