IL67152A - Process for the preparation of 1-hydroxylated vitamin d compounds - Google Patents
Process for the preparation of 1-hydroxylated vitamin d compoundsInfo
- Publication number
- IL67152A IL67152A IL67152A IL6715282A IL67152A IL 67152 A IL67152 A IL 67152A IL 67152 A IL67152 A IL 67152A IL 6715282 A IL6715282 A IL 6715282A IL 67152 A IL67152 A IL 67152A
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- preparation
- hydroxylated vitamin
- hydroxylated
- vitamin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940046008 vitamin d Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5316—Unsaturated acyclic phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5428—Acyclic unsaturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8133019 | 1981-11-02 | ||
| GB8133021 | 1981-11-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL67152A0 IL67152A0 (en) | 1983-03-31 |
| IL67152A true IL67152A (en) | 1986-07-31 |
Family
ID=26281142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL67152A IL67152A (en) | 1981-11-02 | 1982-11-02 | Process for the preparation of 1-hydroxylated vitamin d compounds |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4554105A (xx) |
| EP (1) | EP0078705B1 (xx) |
| CA (1) | CA1221707A (xx) |
| DE (1) | DE3278400D1 (xx) |
| GB (1) | GB2108506B (xx) |
| IL (1) | IL67152A (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719204A (en) * | 1984-03-05 | 1988-01-12 | Wisconsin Alumni Research Foundation | Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs |
| JPH0667898B2 (ja) * | 1989-02-15 | 1994-08-31 | 大同ほくさん株式会社 | ２２，２３―セコビタミンｄ若しくはその活性型またはそれらの誘導体の製造方法 |
| US5185150A (en) * | 1990-08-24 | 1993-02-09 | Wisconsin Alumni Research Fdn. | Cosmetic compositions containing 19-nor-vitamin D compounds |
| US5756783A (en) * | 1990-09-21 | 1998-05-26 | Bone Care International, Inc. | 1α-Hydroxy-24-EPI-vitamin D4 |
| US5869472A (en) * | 1994-07-18 | 1999-02-09 | Bone Care International, Inc. | Synthesis of 1α-hydroxy vitamin D |
| US5869709A (en) * | 1997-05-07 | 1999-02-09 | Humanetics Corporation | Process for effecting allylic oxidation |
| US6686486B1 (en) * | 1997-05-07 | 2004-02-03 | Padma Marwah | Process for effecting allylic oxidation |
| US6252119B1 (en) | 1997-07-28 | 2001-06-26 | Salvador Jorge Antonio Riberiro | Copper-catalysed allylic oxidation using alkyl hydroperoxide |
| AU3088799A (en) | 1998-03-18 | 1999-10-11 | Humanetics Corporation | Process for effecting allylic oxidation using dicarboxylic acid imides and chromium reagents |
| US6432936B1 (en) * | 1999-01-20 | 2002-08-13 | Wisconsin Alumni Research Foundation | Crystalline 1α-hydroxyvitamin D2 and method of purification thereof |
| DE10019861A1 (de) * | 2000-04-18 | 2001-10-31 | Schering Ag | Neues Synthesezwischenprodukt, seine mikrobiologische Herstellung und Verwendung zur Synthese von Vitamin D-Derivaten |
| TW200714580A (en) * | 2005-10-14 | 2007-04-16 | Formosa Lab Inc | Process for preparing vitamin D analogs |
| EP1968383B1 (en) * | 2005-12-12 | 2011-05-11 | Women and Infants Hospital of Rhode Island | Derivatives of vitamin d and therapeutic use thereof |
| US20120184514A1 (en) * | 2009-07-01 | 2012-07-19 | Vitamin Derivatives Inc. | Vitamin d compounds and methods for preparing same |
| CN104119312B (zh) * | 2014-07-28 | 2016-08-24 | 安徽智新生化有限公司 | 一种25-羟基维生素d3的合成方法 |
| CN105348164B (zh) * | 2015-10-29 | 2017-03-29 | 无锡福祈制药有限公司 | 一种1α‑羟基维生素D2的制备方法 |
| CN106748942B (zh) * | 2016-11-28 | 2018-06-29 | 无锡福祈制药有限公司 | 度骨化醇类似物wxfq-65及其合成方法 |
| KR102472541B1 (ko) * | 2019-11-27 | 2022-11-30 | 연성정밀화학(주) | 막사칼시톨의 제조방법 및 그를 위한 중간체 |
| ES2916454B2 (es) * | 2020-12-31 | 2023-01-25 | Laboratorios Vinas S A | Procedimiento industrial para obtener intermedios de derivados de vitamina d por ozonolisis en un reactor en continuo |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4202829A (en) * | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| PH16989A (en) * | 1978-11-07 | 1984-05-04 | Res Inst Medicine Chem | Process for the preparation of 1-hydroxylated vitamin d compounds |
| US4265822A (en) * | 1979-09-10 | 1981-05-05 | Wisconsin Alumni Research Foundation | Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds |
| US4297289A (en) * | 1980-07-17 | 1981-10-27 | Wisconsin Alumni Research Foundation | Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation |
| US4338250A (en) * | 1981-04-27 | 1982-07-06 | Wisconsin Alumni Research Foundation | 1-Hydroxylation process |
-
1982
- 1982-11-02 EP EP82305822A patent/EP0078705B1/en not_active Expired
- 1982-11-02 GB GB08231300A patent/GB2108506B/en not_active Expired
- 1982-11-02 IL IL67152A patent/IL67152A/xx not_active IP Right Cessation
- 1982-11-02 CA CA000414662A patent/CA1221707A/en not_active Expired
- 1982-11-02 DE DE8282305822T patent/DE3278400D1/de not_active Expired
-
1984
- 1984-09-07 US US06/648,309 patent/US4554105A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL67152A0 (en) | 1983-03-31 |
| US4554105A (en) | 1985-11-19 |
| DE3278400D1 (en) | 1988-06-01 |
| EP0078705B1 (en) | 1988-04-27 |
| EP0078705A1 (en) | 1983-05-11 |
| GB2108506B (en) | 1985-08-07 |
| GB2108506A (en) | 1983-05-18 |
| CA1221707A (en) | 1987-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |