IL62871A0 - Production of lineatin - Google Patents

Production of lineatin

Info

Publication number
IL62871A0
IL62871A0 IL62871A IL6287181A IL62871A0 IL 62871 A0 IL62871 A0 IL 62871A0 IL 62871 A IL62871 A IL 62871A IL 6287181 A IL6287181 A IL 6287181A IL 62871 A0 IL62871 A0 IL 62871A0
Authority
IL
Israel
Prior art keywords
see diagramm
lineatin
oxy
formulae
trimethyl
Prior art date
Application number
IL62871A
Original Assignee
Celamerck Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celamerck Gmbh & Co Kg filed Critical Celamerck Gmbh & Co Kg
Publication of IL62871A0 publication Critical patent/IL62871A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Process for the preparation of lineatin, characterized in that 2,2,6-trimethyl-4-R-oxy-7.8-epoxy-3-oxabicyclo[4.1.0] heptane, of formula : see diagramm : EP0040353,P6,F5 wherein R represents lower alkyl or benzyl, is rearranged, under the effect of alkali halides, in an inert solvent under neutral conditions and in the warm, to form a mixture of 2,2,6-trimethyl-4-R-oxy-3-oxy-bicyclo[4.2.0]octan-8-one and -7-one of formulae : see diagramm : EP0040353,P7,F1 and see diagramm : EP0040353,P7,F3 and subsequently the mixture of ketones is reduced with a complex hydride under conventional conditions to form the corresponding alcohols of formulae : see diagramm : EP0040353,P7,F5 and see diagramm : EP0040353,P7,F7 and after separation of the alcohol (c) the latter is converted into racemic lineatin by acid catalysis.
IL62871A 1980-05-16 1981-05-14 Production of lineatin IL62871A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803018635 DE3018635A1 (en) 1980-05-16 1980-05-16 METHOD FOR PRODUCING LINEATIN

Publications (1)

Publication Number Publication Date
IL62871A0 true IL62871A0 (en) 1981-07-31

Family

ID=6102490

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62871A IL62871A0 (en) 1980-05-16 1981-05-14 Production of lineatin

Country Status (8)

Country Link
EP (1) EP0040353B1 (en)
JP (1) JPS57154186A (en)
AT (1) ATE5589T1 (en)
CA (1) CA1167460A (en)
DE (2) DE3018635A1 (en)
DK (1) DK215981A (en)
IL (1) IL62871A0 (en)
NO (1) NO811664L (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1961433C3 (en) * 1969-12-08 1974-06-06 Kali Chemie Ag S-alkoxy ^ -hydroxy-S-methyl-lOmethylene-2,9-dioxatricyclo- (4,3, l, 0 to the power of 3, to the power of 7) -decane and 8-alkoxy-4-hydroxy-3,10-dimethyl- 2,9dioxatricyclo- (4,3,1,0 to the power of 3Jioch 7) -decane and process for their preparation
DE2129507C3 (en) * 1971-06-15 1980-02-14 Kali-Chemie Ag, 3000 Hannover Process for the preparation of 8-alkoxy-3halomethyl-4-acetoxy-10-methylene-2,9dioxatricyclo (43, l, 03 7) decanes
DE2730988A1 (en) * 1977-07-08 1979-01-25 Kali Chemie Pharma Gmbh 3-Azido-methyl-2,9-di:oxa-tri:cyclo-decane derivs. - useful as analgesic, antipyretic and antiphlogistic agents

Also Published As

Publication number Publication date
CA1167460A (en) 1984-05-15
DE3161626D1 (en) 1984-01-19
NO811664L (en) 1981-11-17
EP0040353A1 (en) 1981-11-25
DE3018635A1 (en) 1981-11-26
EP0040353B1 (en) 1983-12-14
JPS57154186A (en) 1982-09-22
DK215981A (en) 1981-11-17
ATE5589T1 (en) 1983-12-15

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