IL59127A0 - Imidazo- and pyrimido-pyridoindoles,their preparation and pharmaceutical compositions containing them - Google Patents
Imidazo- and pyrimido-pyridoindoles,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL59127A0 IL59127A0 IL59127A IL5912780A IL59127A0 IL 59127 A0 IL59127 A0 IL 59127A0 IL 59127 A IL59127 A IL 59127A IL 5912780 A IL5912780 A IL 5912780A IL 59127 A0 IL59127 A0 IL 59127A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- radical
- compound
- alkoxy
- pyrimido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LU, NL, SE. Imidazo and pyrimido-pyrido-indoles in form of racemates or enantiomers corresponding to formula (I) see diagramm : EP0015786,P9,F1 wherein n is 1 or 0, R1 is a hydrogen or halogen atom, an alkyl or alkoxy radical or a CF3 group, R2 is an alkyl, cycloalkyl, cycloalkylalkyl, phenyl or benzyl radical, the two latter radicals being optionally substituted with a halogen atom or an alkyl or alkoxygroup, R3 is a hydrogen atom or an alkyl radical, R4 is a hydrogen atom or an alkyl radical, said alkyl and alkoxy radicals having 1 to 4 carbon atoms, with the exception of the compound for which n = 1, R1 = R3 = R4 = H and R2 = CH3 . 1. Claim for the Contracting State : AT A process for preparing imidazo and pyrimido-pyrido-indoles in form of racemates or enantiomers corresponding to formula (I) see diagramm : EP0015786,P11,F3 wherein n is 1 or 0, R1 is a hydrogen or halogen atom, an alkyl or alkoxy radical or a CF3 group, R2 is an alkyl, cycloalkyl, cycloalkylalkyl, phenyl or benzyl radical, the two latter radicals being optionally substituted with a halogen atom or an alkyl or alkoxy group, R3 is a hydrogen atom or an alkyl radical, R4 is a hydrogen atom or an alkyl radical, said alkyl and alkoxy radicals having 1 to 4 carbon atoms, with the exception of the compound for which n = 1, R1 = R3 = R4 = H and R2 = CH3 , characterized in that a compound of formula (II) see diagramm : EP0015786,P11,F4 is reacted with an amine R2 NH2 , then the intermediate compound obtained, of formula (III) see diagramm : EP0015786,P12,F1 is cyclized by means of formaldehyde in 30% aqueous solution, and, when R4 = H, the corresponding compound (I) may be alkylated to yield a compound (I) wherein R4 is alkyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7902839A FR2447921A1 (en) | 1979-02-05 | 1979-02-05 | IMIDAZO AND PYRIMIDO-PYRIDO-INDOLES AND THEIR APPLICATION IN THERAPEUTICS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL59127A0 true IL59127A0 (en) | 1980-05-30 |
| IL59127A IL59127A (en) | 1983-12-30 |
Family
ID=9221588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL59127A IL59127A (en) | 1979-02-05 | 1980-01-15 | Imidazo-and pyrimido-pyridoindolones,their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0015786B1 (en) |
| JP (1) | JPS55104282A (en) |
| AT (1) | ATE878T1 (en) |
| AU (1) | AU528425B2 (en) |
| CA (1) | CA1129412A (en) |
| DE (1) | DE3060292D1 (en) |
| DK (1) | DK17080A (en) |
| ES (1) | ES487712A1 (en) |
| FR (1) | FR2447921A1 (en) |
| GR (1) | GR74450B (en) |
| IE (1) | IE49629B1 (en) |
| IL (1) | IL59127A (en) |
| NO (1) | NO151289C (en) |
| PT (1) | PT70697A (en) |
| ZA (1) | ZA80241B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485538B1 (en) * | 1980-06-24 | 1985-01-11 | Chinoin Gyogyszer Es Vegyeszet | NEW PROCESS FOR THE PREPARATION OF INDOLO (2 ', 3'; 3,4) -PYRIDO (1,2-B) QUINAZOLINE-5-ONES |
| JPH0425576Y2 (en) * | 1987-02-02 | 1992-06-18 | ||
| DE3827727A1 (en) * | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE OF SUCH CONNECTIONS FOR CARDIRO PROTECTION |
-
1979
- 1979-02-05 FR FR7902839A patent/FR2447921A1/en active Granted
- 1979-12-27 NO NO794270A patent/NO151289C/en unknown
-
1980
- 1980-01-14 JP JP300280A patent/JPS55104282A/en active Granted
- 1980-01-15 IE IE77/80A patent/IE49629B1/en unknown
- 1980-01-15 DK DK17080A patent/DK17080A/en not_active Application Discontinuation
- 1980-01-15 AT AT80400049T patent/ATE878T1/en active
- 1980-01-15 ZA ZA00800241A patent/ZA80241B/en unknown
- 1980-01-15 CA CA343,699A patent/CA1129412A/en not_active Expired
- 1980-01-15 IL IL59127A patent/IL59127A/en unknown
- 1980-01-15 GR GR60961A patent/GR74450B/el unknown
- 1980-01-15 ES ES487712A patent/ES487712A1/en not_active Expired
- 1980-01-15 DE DE8080400049T patent/DE3060292D1/en not_active Expired
- 1980-01-15 AU AU54629/80A patent/AU528425B2/en not_active Ceased
- 1980-01-15 PT PT70697A patent/PT70697A/en unknown
- 1980-01-15 EP EP80400049A patent/EP0015786B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO151289B (en) | 1984-12-03 |
| EP0015786A1 (en) | 1980-09-17 |
| EP0015786B1 (en) | 1982-04-21 |
| IE800077L (en) | 1980-08-05 |
| JPS616073B2 (en) | 1986-02-24 |
| PT70697A (en) | 1980-02-01 |
| DE3060292D1 (en) | 1982-06-03 |
| FR2447921B1 (en) | 1982-01-29 |
| IE49629B1 (en) | 1985-11-13 |
| GR74450B (en) | 1984-06-28 |
| NO794270L (en) | 1980-08-06 |
| ES487712A1 (en) | 1980-06-16 |
| JPS55104282A (en) | 1980-08-09 |
| AU528425B2 (en) | 1983-04-28 |
| ZA80241B (en) | 1980-12-31 |
| AU5462980A (en) | 1980-08-14 |
| CA1129412A (en) | 1982-08-10 |
| FR2447921A1 (en) | 1980-08-29 |
| DK17080A (en) | 1980-08-06 |
| ATE878T1 (en) | 1982-05-15 |
| IL59127A (en) | 1983-12-30 |
| NO151289C (en) | 1985-03-13 |
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