IL44649A - Device for releasing active agent such as drugs to an aqueous environment and process for producing the same - Google Patents

Claims (1)

1. 4464 CLAIM A active to on environment in that tho device lo a plurality o discrete of an aotlvo agent aa herein defined that la an effootlvo heroi each of to 100 and into a unit body by a which to tho of insoluble in tho aqueous and to tho of water and hao a otxon th vhich exceeded by tho preosuro ability of individual aotlvo the depots to b and the to by of tho total of the lo placed tho 1a by the depota a serially inward beginning the dopote the of tho devioe thereby to polymer to allowing of tho aotlvo agent thoro devioe of I tho dopoti f ft The device of claim 1 wherein the depots each comprise an active agent and an added osmotically effective The device of claim 1 wherein the unit body is covered on a portion of its surface by a barrier material which is substantially impermeable to the passage of the active agent and the aqueous environment and has the remainder of its surface exposed to the aqueous The device of claim 4 wherein the unit body is having only its ends exposed to the aqueous environment The device of claim 1 wherein the unit body is substantially two The delivery device of claim 1 wherein the polymer has a tensile strength of from 14 to 700 an elongation at break of from 10 to and a permeability to water of from cc of water micron cm2 hr atmosphere The of any of tho active is of an of clalrgn active ia on ocular drag tmit body io adapted for placement and retention in the of tho The of wherein the polyaer an vinyl acetate and the ocular drug ia a salt of process for produoing tho device of olala oharaoterleed dispersing and surrounding a plurality of discrete depots of an active ao that an chaotically solute heroin oach of to 100 in polyaer union substantially to tho of active the aqueous environment and to tho of and a strength which exceeded by the pressure ability of the solute active the depots constituting to by and the polyaer to by of the total of the devioe the dispersion of into a unit sized and shaped for Introduction into said aqueous The process of claim 11 laminating a barrier layer to a portion of the surface of the unit body which layer is substantially free of active agent and impermeable to the passage of active The process of claim 11 covering a portion of the surface of the unit with a barrier material which is substantially impermeable to the passage of active agent and to the aqueous The process of any of claims wherein the active agent is a The process of any of claims wherein the active agent is an ocular drug and the unit body is sized and shaped for placement and retention in the of the eye The process of claim 15 wherein the ocular drug is a salt of A method for releasing an active agent in an aqueous environment characterized by introducing the device of claim 1 into the The method of claim 17 wherein the active agent is a drug and the aqueous environment is an aqueous environment of the human The method of claim 18 wherein the drug is an ocular drug and the aqueous environment is the of the The method of claim 19 wherein the ocular drug is a salt of The device as claimed in claim 1 and tially as described in 6 and 7 of the accompanying ings The device as claimed in claim 1 and stantially as described in 8 of the accompanying The device as claimed in claim 1 and tially as described in 9 and 10 of the accompanying drawings The device as claimed in claim 1 and tially as described in 10 and 11 of the accompanying drawings The device as claimed in claim 1 and stantially as described in 12 and 13 of the accompanying drawings The device as claimed in claim 1 and tially as described in 14 and 15 of the accompanying drawings The device as claimed in claim 1 and tially as described in any of the specific examples before set The process as claimed in claim 11 and tially as described in any of the specific examples hereinbefore set The method as claimed in claim 17 and specifically as described in any of the specific examples hereinbefore set insufficientOCRQuality