IL44401A - Aerosol dispenser for inhalable powdered medicaments - Google Patents
Aerosol dispenser for inhalable powdered medicamentsInfo
- Publication number
- IL44401A IL44401A IL44401A IL4440174A IL44401A IL 44401 A IL44401 A IL 44401A IL 44401 A IL44401 A IL 44401A IL 4440174 A IL4440174 A IL 4440174A IL 44401 A IL44401 A IL 44401A
- Authority
- IL
- Israel
- Prior art keywords
- mouthpiece
- container
- chamber
- button
- cylindrical
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract 4
- 239000004479 aerosol dispenser Substances 0.000 title claims 2
- 239000000443 aerosol Substances 0.000 claims abstract 7
- 239000002245 particle Substances 0.000 claims abstract 2
- 239000000428 dust Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 abstract 2
- 230000009885 systemic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A combination aerosol container carrier and deceleration chamber carries an aerosol container in one configuration and in another dispenses powdered medicament from the aerosol container with inhaled particles predominantly below 10 microns in size at a low velocity which gives a comparatively high degree of topical effect in the lungs as compared with systemic effect from powders absorbed in the mouth. The lungs may be used as an effective administration route for systemic medicament effect.
[US3809294A]
Claims (1)
1. An aerosol dispenser for dispensing uniform dosages of a finely-divided powdered medicament suspended in a propellant at a low velocity i in inhalable dry aerosol form in the particle size range of 0.5 to 10 microns, comprising a circular cylindrical container carrier (20) and deceleration chamber (11) consisting essentially of a cylindrical barrel (12) , and, at one end thereof, a mouthpiece (13) and a mouthpiece-to-chamber flare (14) , the mouthpiece being adapted to fit into a human mouth, said mouthpiece being cylindrical, and positioned coaxial with the cylindrical barrel (12) by said flare (14) , a mouthpiece cap (15) , adapted to removably engage and close the mouthpiece (13) in dust excluding relationship, and at the other end of said chamber a removable container holder (16) , adapted to close the deceleration chamber (11) in essentially air tight relationship, comprising a holder flange (17) , adapted to fit in sealing relationship with the cylindrical barrel (12) of said chamber, a container holding sleeve (19) effectively coaxial and integral with the holder flange (17) and of a size to hold a circular aerosol container with a friction-fit, and a button holder (22) coaxial with the holder flange (17) with means to hold an actuating button (24) on an aerosol container (20) in indexed relationship to discharge axially with the deceleration chamber (11) , in dose administering position, means to close the button holding means in dust excluding relationship in a carrier configuration, and a circular cylindrical aerosol container (20) having a dose metering valve having thereon an actuating button (24) , which button fits into said button holding means in a dispensing configuration and which container (20) fits interiorly of the cylindrical deceleration chamber (11) in a storage configuration. S. HOROWITZ & CO. AGENTS FOR APPLICANTS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00374176A US3809294A (en) | 1973-06-27 | 1973-06-27 | Dispensing lung contacting powdered medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44401A0 IL44401A0 (en) | 1974-06-30 |
| IL44401A true IL44401A (en) | 1976-10-31 |
Family
ID=23475640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44401A IL44401A (en) | 1973-06-27 | 1974-03-12 | Aerosol dispenser for inhalable powdered medicaments |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US3809294A (en) |
| JP (1) | JPS6010737B2 (en) |
| AR (1) | AR198562A1 (en) |
| AT (1) | AT342211B (en) |
| BE (1) | BE813512A (en) |
| CA (1) | CA1043208A (en) |
| CH (2) | CH577832A5 (en) |
| CS (1) | CS182257B2 (en) |
| DD (1) | DD125188A5 (en) |
| DE (1) | DE2415360C2 (en) |
| DK (1) | DK152967C (en) |
| ES (1) | ES427755A1 (en) |
| FR (1) | FR2234905B1 (en) |
| GB (1) | GB1471917A (en) |
| IE (1) | IE40616B1 (en) |
| IL (1) | IL44401A (en) |
| IT (1) | IT1003994B (en) |
| NL (1) | NL178655C (en) |
| PH (1) | PH11643A (en) |
| PL (1) | PL89980B1 (en) |
| SE (1) | SE405448B (en) |
| SU (1) | SU537614A3 (en) |
| YU (1) | YU36435B (en) |
| ZA (1) | ZA741633B (en) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998226A (en) * | 1975-09-22 | 1976-12-21 | Edward G. Gomez | Inhalation device for encapsulated concentrates |
| US3994421A (en) * | 1975-09-29 | 1976-11-30 | American Cyanamid Company | Unitary therapeutic aerosol dispenser |
| SE408265B (en) * | 1975-12-12 | 1979-06-05 | Draco Ab | DEVICE FOR CARBON DIOXIDE POWERED ENDOSAEROSOL, INTENDED FOR INHALATION |
| GR69682B (en) * | 1978-09-11 | 1982-07-08 | Newhouse Michael T | |
| DE3348370C2 (en) * | 1982-10-08 | 2001-10-11 | Glaxo Group Ltd | Hand-held inhaler for powder or liq. medical inhalants |
| IT1217890B (en) * | 1988-06-22 | 1990-03-30 | Chiesi Farma Spa | DOSED AEROSOL INHALATION DEVICE |
| US5169639A (en) * | 1988-09-19 | 1992-12-08 | Edward Mendell Co., Inc. | Controlled release verapamil tablets |
| US5040527A (en) * | 1990-12-18 | 1991-08-20 | Healthscan Products Inc. | Metered dose inhalation unit with slide means |
| US5186164A (en) * | 1991-03-15 | 1993-02-16 | Puthalath Raghuprasad | Mist inhaler |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| US5658549A (en) * | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
| US5744123A (en) * | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| US5916540A (en) | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
| DE69227257T2 (en) | 1991-12-12 | 1999-03-25 | Glaxo Group Ltd | DRUG |
| US5653962A (en) * | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| US5674471A (en) * | 1991-12-12 | 1997-10-07 | Glaxo Group Limited | Aerosol formulations containing P134a and salbutamol |
| DE69205177T2 (en) * | 1991-12-12 | 1996-03-21 | Glaxo Group Ltd., Greenford, Middlesex | Pharmaceutical aerosol formulation. |
| US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
| US7101534B1 (en) | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
| AU675633B2 (en) * | 1991-12-18 | 1997-02-13 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
| US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
| GB9322014D0 (en) * | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US5839429A (en) * | 1994-03-25 | 1998-11-24 | Astra Aktiebolag | Method and apparatus in connection with an inhaler |
| US5598836A (en) * | 1995-05-26 | 1997-02-04 | Healthscan Products, Inc. | Metered dose inhalation unit with slide means |
| US5976573A (en) | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
| DE19740617A1 (en) * | 1997-09-16 | 1999-03-18 | Palas Gmbh | Method and device for producing a solid aerosol |
| US6345617B1 (en) | 1997-09-26 | 2002-02-12 | 1263152 Ontario Inc. | Aerosol medication delivery apparatus and system |
| US6293279B1 (en) | 1997-09-26 | 2001-09-25 | Trudell Medical International | Aerosol medication delivery apparatus and system |
| US6557549B2 (en) | 2000-04-11 | 2003-05-06 | Trudell Medical International | Aerosol delivery apparatus with positive expiratory pressure capacity |
| WO2002092154A1 (en) * | 2001-04-26 | 2002-11-21 | New England Pharmaceuticals, Inc. | Metered dose delivery device for liquid and powder agents |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| US7582284B2 (en) * | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| US20030205226A1 (en) | 2002-05-02 | 2003-11-06 | Pre Holding, Inc. | Aerosol medication inhalation system |
| US6904908B2 (en) | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
| JP2007505136A (en) * | 2003-09-10 | 2007-03-08 | マツプ・フアーマシユーテイカルズ・インコーポレーテツド | Aerosol formulation for delivering dihydroergotamine to systemic circulation by pulmonary inhalation |
| CA2616997C (en) | 2004-09-13 | 2014-12-23 | Oriel Therapeutics, Inc. | Dry powder inhalers that inhibit agglomeration, related devices and methods |
| NL1027255C2 (en) * | 2004-10-15 | 2006-04-19 | Lab Tickner Ag | Device for removing a tick. |
| CA2677838C (en) * | 2007-02-11 | 2017-08-01 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
| WO2010151804A1 (en) * | 2009-06-26 | 2010-12-29 | Map Pharmaceuticals, Inc. | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
| CA156938S (en) | 2013-02-14 | 2014-07-08 | Clement Clarke Int Ltd | Spacer for an asthma inhaler |
| US10207065B2 (en) | 2013-07-12 | 2019-02-19 | John H. Silva | Mouthpiece for inhalers |
| USD748242S1 (en) * | 2014-07-11 | 2016-01-26 | H. Stuart Campbell | Inhaler mouthpiece |
| CN116528901A (en) * | 2020-12-01 | 2023-08-01 | 瑞沃斯帕有限责任公司 | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis, and pulmonary edema |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE555972A (en) * | 1956-03-21 | |||
| US2890697A (en) * | 1957-03-15 | 1959-06-16 | Wilton E Van Sickle | Enclosed medicament container and atomizer |
| US3012555A (en) * | 1959-05-18 | 1961-12-12 | Meshberg Philip | Dispensing package for material under pressure |
| US3183907A (en) * | 1962-06-25 | 1965-05-18 | Merck & Co Inc | Device for inhalation aerosol |
| JPS4214552Y1 (en) * | 1964-12-30 | 1967-08-18 | ||
| JPS4514212Y1 (en) * | 1966-11-02 | 1970-06-16 | ||
| US3559851A (en) * | 1969-05-27 | 1971-02-02 | Valve Corp Of America | Fully-emptying valve assemblage |
| JPS566680Y2 (en) * | 1972-04-19 | 1981-02-13 |
-
1973
- 1973-06-27 US US00374176A patent/US3809294A/en not_active Expired - Lifetime
-
1974
- 1974-03-08 CA CA194,459A patent/CA1043208A/en not_active Expired
- 1974-03-12 ZA ZA00741633A patent/ZA741633B/en unknown
- 1974-03-12 IL IL44401A patent/IL44401A/en unknown
- 1974-03-19 IE IE574/74A patent/IE40616B1/en unknown
- 1974-03-21 PH PH15648A patent/PH11643A/en unknown
- 1974-03-21 GB GB1270674A patent/GB1471917A/en not_active Expired
- 1974-03-28 AR AR253017A patent/AR198562A1/en active
- 1974-03-29 DE DE2415360A patent/DE2415360C2/en not_active Expired
- 1974-04-02 IT IT49957/74A patent/IT1003994B/en active
- 1974-04-04 NL NLAANVRAGE7404626,A patent/NL178655C/en not_active IP Right Cessation
- 1974-04-08 DD DD177768A patent/DD125188A5/xx unknown
- 1974-04-09 SU SU2017264A patent/SU537614A3/en active
- 1974-04-09 BE BE143026A patent/BE813512A/en not_active IP Right Cessation
- 1974-04-09 YU YU00989/74A patent/YU36435B/en unknown
- 1974-04-10 FR FR7412670A patent/FR2234905B1/fr not_active Expired
- 1974-04-10 AT AT299974A patent/AT342211B/en not_active IP Right Cessation
- 1974-04-10 JP JP49041581A patent/JPS6010737B2/en not_active Expired
- 1974-04-11 SE SE7405022A patent/SE405448B/en unknown
- 1974-04-23 CH CH555174A patent/CH577832A5/xx not_active IP Right Cessation
- 1974-06-25 PL PL1974172163A patent/PL89980B1/pl unknown
- 1974-06-26 DK DK343874A patent/DK152967C/en not_active IP Right Cessation
- 1974-06-27 CS CS7400004539A patent/CS182257B2/en unknown
- 1974-06-27 ES ES427755A patent/ES427755A1/en not_active Expired
-
1975
- 1975-10-13 CH CH1325075A patent/CH620207A5/de not_active IP Right Cessation
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