IL44086A - Derivatives of 2-aminoindane their preparation and pharmaceutical compositions containing them - Google Patents
Derivatives of 2-aminoindane their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL44086A IL44086A IL44086A IL4408674A IL44086A IL 44086 A IL44086 A IL 44086A IL 44086 A IL44086 A IL 44086A IL 4408674 A IL4408674 A IL 4408674A IL 44086 A IL44086 A IL 44086A
- Authority
- IL
- Israel
- Prior art keywords
- aminoindane
- lower alkyl
- acid addition
- addition salts
- well
- Prior art date
Links
- LMHHFZAXSANGGM-UHFFFAOYSA-N 2-aminoindane Chemical class C1=CC=C2CC(N)CC2=C1 LMHHFZAXSANGGM-UHFFFAOYSA-N 0.000 title claims 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 239000002253 acid Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- MHVHCDLCLNXADJ-UHFFFAOYSA-N n-phenyl-2,3-dihydro-1h-inden-2-amine Chemical compound C1C2=CC=CC=C2CC1NC1=CC=CC=C1 MHVHCDLCLNXADJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB563173A GB1462036A (en) | 1973-02-05 | 1973-02-05 | Aminoindane derivatives |
| GB1030273 | 1973-03-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44086A0 IL44086A0 (en) | 1974-05-16 |
| IL44086A true IL44086A (en) | 1976-11-30 |
Family
ID=26240034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44086A IL44086A (en) | 1973-02-05 | 1974-01-25 | Derivatives of 2-aminoindane their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3923887A (es) |
| JP (1) | JPS5327264B2 (es) |
| AR (1) | AR201218A1 (es) |
| CA (1) | CA1022172A (es) |
| CH (1) | CH587801A5 (es) |
| DD (2) | DD112989A5 (es) |
| DE (1) | DE2405094A1 (es) |
| ES (1) | ES422906A1 (es) |
| FR (1) | FR2215958B1 (es) |
| GB (1) | GB1462036A (es) |
| HU (1) | HU169033B (es) |
| IL (1) | IL44086A (es) |
| LU (1) | LU69308A1 (es) |
| NL (1) | NL7401501A (es) |
| YU (1) | YU36010B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018897A (en) * | 1974-07-03 | 1977-04-19 | Eli Lilly And Company | Antiarrhythmic agents |
| US3987201A (en) * | 1974-12-24 | 1976-10-19 | Eli Lilly And Company | Method for treating arrhythmia |
| US4192883A (en) * | 1976-04-09 | 1980-03-11 | Pierre Fabre, S.A. | Amides of pyrrolidinoethylamine which can be used in lung therapy |
| EP0035868A1 (en) * | 1980-03-07 | 1981-09-16 | Takeda Chemical Industries, Ltd. | Bicyclic compounds, their production and use |
| US4873241A (en) * | 1988-10-31 | 1989-10-10 | Fisons Corporation | 2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics |
| DK1185267T3 (da) | 1999-06-10 | 2006-12-11 | Bridge Pharma Inc | Dermale bedövelsesmidler |
| EP1658847A3 (en) * | 1999-06-10 | 2006-07-26 | Bridge Pharma, Inc. | Indane derivatives as dermal anesthetic agents |
| US7718674B2 (en) * | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| US20060079558A1 (en) * | 2004-09-27 | 2006-04-13 | Bridge Pharma. Inc. | R-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics |
| WO2008011161A2 (en) * | 2006-07-21 | 2008-01-24 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2948736A (en) * | 1957-08-05 | 1960-08-09 | Cilag Chemie | New anilides and process for their production |
| BE667486A (es) * | 1964-07-27 |
-
1973
- 1973-02-05 GB GB563173A patent/GB1462036A/en not_active Expired
-
1974
- 1974-01-24 CA CA190,892A patent/CA1022172A/en not_active Expired
- 1974-01-25 IL IL44086A patent/IL44086A/en unknown
- 1974-01-29 FR FR7402907A patent/FR2215958B1/fr not_active Expired
- 1974-01-30 JP JP1325674A patent/JPS5327264B2/ja not_active Expired
- 1974-01-31 YU YU234/74A patent/YU36010B/xx unknown
- 1974-02-02 DE DE19742405094 patent/DE2405094A1/de not_active Withdrawn
- 1974-02-04 DD DD176357A patent/DD112989A5/xx unknown
- 1974-02-04 DD DD181490A patent/DD114906A5/xx unknown
- 1974-02-04 NL NL7401501A patent/NL7401501A/xx not_active Application Discontinuation
- 1974-02-04 LU LU69308A patent/LU69308A1/xx unknown
- 1974-02-04 ES ES422906A patent/ES422906A1/es not_active Expired
- 1974-02-04 HU HUCI1439A patent/HU169033B/hu unknown
- 1974-02-04 AR AR252184A patent/AR201218A1/es active
- 1974-02-04 CH CH151874A patent/CH587801A5/xx not_active IP Right Cessation
- 1974-02-05 US US439773A patent/US3923887A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2215958B1 (es) | 1978-01-06 |
| CA1022172A (en) | 1977-12-06 |
| FR2215958A1 (es) | 1974-08-30 |
| JPS5327264B2 (es) | 1978-08-07 |
| ES422906A1 (es) | 1976-05-01 |
| HU169033B (es) | 1976-09-28 |
| IL44086A0 (en) | 1974-05-16 |
| GB1462036A (en) | 1977-01-19 |
| YU23474A (en) | 1981-04-30 |
| NL7401501A (es) | 1974-08-07 |
| LU69308A1 (es) | 1974-05-29 |
| US3923887A (en) | 1975-12-02 |
| DD112989A5 (es) | 1975-05-12 |
| AU6508874A (en) | 1975-08-07 |
| DD114906A5 (es) | 1975-09-05 |
| CH587801A5 (es) | 1977-05-13 |
| AR201218A1 (es) | 1975-02-21 |
| JPS49102659A (es) | 1974-09-27 |
| DE2405094A1 (de) | 1974-08-08 |
| YU36010B (en) | 1981-11-13 |
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