IL42735A - Compositions containing (cyclo) alkyl alkyl sulfones and sulfoxides having a physiological cooling effect - Google Patents
Compositions containing (cyclo) alkyl alkyl sulfones and sulfoxides having a physiological cooling effectInfo
- Publication number
- IL42735A IL42735A IL42735A IL4273573A IL42735A IL 42735 A IL42735 A IL 42735A IL 42735 A IL42735 A IL 42735A IL 4273573 A IL4273573 A IL 4273573A IL 42735 A IL42735 A IL 42735A
- Authority
- IL
- Israel
- Prior art keywords
- product according
- carrier
- sulphoxide
- cooling effect
- added
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 121
- -1 alkyl alkyl sulfones Chemical class 0.000 title claims description 21
- 230000000694 effects Effects 0.000 title description 55
- 238000001816 cooling Methods 0.000 title description 52
- 150000003462 sulfoxides Chemical class 0.000 title description 2
- 239000006210 lotion Substances 0.000 claims description 26
- 239000004615 ingredient Substances 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 230000000699 topical effect Effects 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 210000000653 nervous system Anatomy 0.000 claims description 4
- 125000002015 acyclic group Chemical group 0.000 claims description 3
- 238000005470 impregnation Methods 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 230000001055 chewing effect Effects 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 50
- 150000001875 compounds Chemical class 0.000 description 43
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 32
- 239000002304 perfume Substances 0.000 description 20
- 235000019504 cigarettes Nutrition 0.000 description 19
- 238000009472 formulation Methods 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 239000002674 ointment Substances 0.000 description 18
- 241000208125 Nicotiana Species 0.000 description 14
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 14
- 230000035807 sensation Effects 0.000 description 14
- 235000019615 sensations Nutrition 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 125000001174 sulfone group Chemical group 0.000 description 12
- 210000001519 tissue Anatomy 0.000 description 12
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 10
- 229940075894 denatured ethanol Drugs 0.000 description 10
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 239000000344 soap Substances 0.000 description 10
- 244000153158 Ammi visnaga Species 0.000 description 9
- 235000010585 Ammi visnaga Nutrition 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 230000001476 alcoholic effect Effects 0.000 description 9
- 230000002421 anti-septic effect Effects 0.000 description 9
- 210000001508 eye Anatomy 0.000 description 9
- 239000000796 flavoring agent Substances 0.000 description 9
- 238000002156 mixing Methods 0.000 description 8
- 239000002324 mouth wash Substances 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 239000004141 Sodium laurylsulphate Substances 0.000 description 7
- 239000000865 liniment Substances 0.000 description 7
- 229940041616 menthol Drugs 0.000 description 7
- 239000012188 paraffin wax Substances 0.000 description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- 235000008504 concentrate Nutrition 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 239000000155 melt Substances 0.000 description 6
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 6
- 229940051866 mouthwash Drugs 0.000 description 6
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 239000002453 shampoo Substances 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 5
- 235000012411 boiled sweets Nutrition 0.000 description 5
- 229910021538 borax Inorganic materials 0.000 description 5
- 239000000551 dentifrice Substances 0.000 description 5
- 239000002781 deodorant agent Substances 0.000 description 5
- 210000004400 mucous membrane Anatomy 0.000 description 5
- 239000003380 propellant Substances 0.000 description 5
- 235000010339 sodium tetraborate Nutrition 0.000 description 5
- 235000014214 soft drink Nutrition 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229940069428 antacid Drugs 0.000 description 4
- 239000003159 antacid agent Substances 0.000 description 4
- 230000001458 anti-acid effect Effects 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 230000035597 cooling sensation Effects 0.000 description 4
- 201000006549 dyspepsia Diseases 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 239000008311 hydrophilic ointment Substances 0.000 description 4
- 229940040145 liniment Drugs 0.000 description 4
- 229960001047 methyl salicylate Drugs 0.000 description 4
- 229940081974 saccharin Drugs 0.000 description 4
- 235000019204 saccharin Nutrition 0.000 description 4
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 4
- 230000000391 smoking effect Effects 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- 235000012222 talc Nutrition 0.000 description 4
- AYCXBIDBURRTGP-UHFFFAOYSA-N 1,2-diethyl-1-hexylsulfinylcyclohexane Chemical compound CCCCCCS(=O)C1(CC)CCCCC1CC AYCXBIDBURRTGP-UHFFFAOYSA-N 0.000 description 3
- FKAXCYFKCARJQA-UHFFFAOYSA-N 1-butylsulfinyl-1-(3-methylbutyl)cyclohexane Chemical compound CCCCS(=O)C1(CCC(C)C)CCCCC1 FKAXCYFKCARJQA-UHFFFAOYSA-N 0.000 description 3
- YRYYOGUXBQGBFD-UHFFFAOYSA-N 1-hexylsulfinyl-1-(2-methylpropyl)cyclohexane Chemical compound CCCCCCS(=O)C1(CC(C)C)CCCCC1 YRYYOGUXBQGBFD-UHFFFAOYSA-N 0.000 description 3
- CPCLGLSUXGQAMK-UHFFFAOYSA-N 2-butylsulfinyl-4-methyl-1-propan-2-ylcyclohexane Chemical compound CCCCS(=O)C1CC(C)CCC1C(C)C CPCLGLSUXGQAMK-UHFFFAOYSA-N 0.000 description 3
- NCXXWKPCZBXFTP-UHFFFAOYSA-N 4-methyl-2-methylsulfinyl-1-propan-2-ylcyclohexane Chemical compound CC(C)C1CCC(C)CC1S(C)=O NCXXWKPCZBXFTP-UHFFFAOYSA-N 0.000 description 3
- TWHPQBDXPGHTJT-UHFFFAOYSA-N 4-methyl-2-methylsulfonyl-1-propan-2-ylcyclohexane Chemical compound CC(C)C1CCC(C)CC1S(C)(=O)=O TWHPQBDXPGHTJT-UHFFFAOYSA-N 0.000 description 3
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- 241000208680 Hamamelis mollis Species 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- 235000013361 beverage Nutrition 0.000 description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 3
- 239000004327 boric acid Substances 0.000 description 3
- 210000005252 bulbus oculi Anatomy 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 229960000541 cetyl alcohol Drugs 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 150000001923 cyclic compounds Chemical class 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000000744 eyelid Anatomy 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 3
- 239000001095 magnesium carbonate Substances 0.000 description 3
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- BXNRKCXZILSQHE-UHFFFAOYSA-N propane-1,2,3-triol;sulfuric acid Chemical compound OS(O)(=O)=O.OCC(O)CO BXNRKCXZILSQHE-UHFFFAOYSA-N 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 3
- 229940118846 witch hazel Drugs 0.000 description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 3
- 239000011686 zinc sulphate Substances 0.000 description 3
- 235000009529 zinc sulphate Nutrition 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- XEZBLFGMIODLGK-UHFFFAOYSA-N 1,3-dimethyl-2-methylsulfinylcyclohexane Chemical compound CC1CCCC(C)C1S(C)=O XEZBLFGMIODLGK-UHFFFAOYSA-N 0.000 description 2
- HRBIJRSZROQEJC-UHFFFAOYSA-N 1,4-dimethyl-2-propan-2-ylsulfinylcyclohexane Chemical compound CC(C)S(=O)C1CC(C)CCC1C HRBIJRSZROQEJC-UHFFFAOYSA-N 0.000 description 2
- GTALHHCTFKIKHC-UHFFFAOYSA-N 1-(2,3-dimethylbutan-2-ylsulfinyl)hexane Chemical compound CCCCCCS(=O)C(C)(C)C(C)C GTALHHCTFKIKHC-UHFFFAOYSA-N 0.000 description 2
- ZRBXAQHDYZBGFE-UHFFFAOYSA-N 1-(3-methylpentan-3-ylsulfinyl)hexane Chemical compound CCCCCCS(=O)C(C)(CC)CC ZRBXAQHDYZBGFE-UHFFFAOYSA-N 0.000 description 2
- LDBRSQHIOCBWDC-UHFFFAOYSA-N 1-(3-methylpentan-3-ylsulfonyl)hexane Chemical compound CCCCCCS(=O)(=O)C(C)(CC)CC LDBRSQHIOCBWDC-UHFFFAOYSA-N 0.000 description 2
- FMXWFFPXAJILMN-UHFFFAOYSA-N 1-butylsulfinyl-1-(2-methylpropyl)cyclohexane Chemical compound CCCCS(=O)C1(CC(C)C)CCCCC1 FMXWFFPXAJILMN-UHFFFAOYSA-N 0.000 description 2
- LOWMYOWHQMKBTM-UHFFFAOYSA-N 1-butylsulfinylbutane Chemical compound CCCCS(=O)CCCC LOWMYOWHQMKBTM-UHFFFAOYSA-N 0.000 description 2
- KCCXVBILFONVMS-UHFFFAOYSA-N 1-methyl-3-propan-2-ylsulfinylcyclohexane Chemical compound CC(C)S(=O)C1CCCC(C)C1 KCCXVBILFONVMS-UHFFFAOYSA-N 0.000 description 2
- CHZUAFGLUYQBIY-UHFFFAOYSA-N 1-methyl-4-propan-2-ylsulfinylcyclohexane Chemical compound CC(C)S(=O)C1CCC(C)CC1 CHZUAFGLUYQBIY-UHFFFAOYSA-N 0.000 description 2
- IECNQCJGHDCGSY-UHFFFAOYSA-N 2-methyl-3-propylsulfinylnonane Chemical compound CCCCCCC(C(C)C)S(=O)CCC IECNQCJGHDCGSY-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 235000003911 Arachis Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 241000207199 Citrus Species 0.000 description 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000004479 aerosol dispenser Substances 0.000 description 2
- 235000013334 alcoholic beverage Nutrition 0.000 description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940031955 anhydrous lanolin Drugs 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- 239000001273 butane Substances 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 239000007765 cera alba Substances 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 229940038472 dicalcium phosphate Drugs 0.000 description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 2
- 229960004068 hexachlorophene Drugs 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 235000015243 ice cream Nutrition 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000000391 magnesium silicate Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 210000001640 nerve ending Anatomy 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000007968 orange flavor Substances 0.000 description 2
- 235000015205 orange juice Nutrition 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000011369 resultant mixture Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- 239000004291 sulphur dioxide Substances 0.000 description 2
- 235000010269 sulphur dioxide Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- RIMUBRZJVIXWAU-UHFFFAOYSA-N 1,1,3-trimethyl-5-propylsulfonylcyclohexane Chemical compound CCCS(=O)(=O)C1CC(C)CC(C)(C)C1 RIMUBRZJVIXWAU-UHFFFAOYSA-N 0.000 description 1
- ABENZMDNAMVFTN-UHFFFAOYSA-N 1,2-diethyl-1-hexylsulfonylcyclohexane Chemical compound CCCCCCS(=O)(=O)C1(CC)CCCCC1CC ABENZMDNAMVFTN-UHFFFAOYSA-N 0.000 description 1
- CQTUVPTYOFTHNF-UHFFFAOYSA-N 1,3-dimethyl-2-methylsulfonylcyclohexane Chemical compound CC1CCCC(C)C1S(C)(=O)=O CQTUVPTYOFTHNF-UHFFFAOYSA-N 0.000 description 1
- ZJGCUOVTDJHQPZ-UHFFFAOYSA-N 1,4-dimethyl-2-methylsulfinylcyclohexane Chemical compound CC1CCC(C)C(S(C)=O)C1 ZJGCUOVTDJHQPZ-UHFFFAOYSA-N 0.000 description 1
- QOJQDXRBMFHEKW-UHFFFAOYSA-N 1,4-dimethyl-2-methylsulfonylcyclohexane Chemical compound CC1CCC(C)C(S(C)(=O)=O)C1 QOJQDXRBMFHEKW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A23L27/20—Synthetic spices, flavouring agents or condiments
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/203—Alicyclic compounds
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
- Noodles (AREA)
- Seasonings (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3399472 | 1972-07-20 | ||
| GB4903972A GB1432354A (en) | 1972-07-20 | 1972-10-24 | Compounds having a physiological cooling effect and compo sitions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42735A0 IL42735A0 (en) | 1973-10-25 |
| IL42735A true IL42735A (en) | 1977-02-28 |
Family
ID=26262117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42735A IL42735A (en) | 1972-07-20 | 1973-07-13 | Compositions containing (cyclo) alkyl alkyl sulfones and sulfoxides having a physiological cooling effect |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4985245A (en:Method) |
| AT (1) | AT330362B (en:Method) |
| CH (1) | CH576240A5 (en:Method) |
| DD (1) | DD105390A5 (en:Method) |
| DE (1) | DE2334985A1 (en:Method) |
| EG (1) | EG10911A (en:Method) |
| FR (1) | FR2193603B1 (en:Method) |
| GB (1) | GB1432354A (en:Method) |
| HU (1) | HU167694B (en:Method) |
| IE (1) | IE37935B1 (en:Method) |
| IL (1) | IL42735A (en:Method) |
| IT (1) | IT1048130B (en:Method) |
| LU (1) | LU68036A1 (en:Method) |
| NL (1) | NL7310022A (en:Method) |
| RO (1) | RO67322A2 (en:Method) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4530493A (en) | 1992-06-17 | 1994-01-04 | Procter & Gamble Company, The | Coolant compositions with reduced stinging |
| US6365215B1 (en) * | 2000-11-09 | 2002-04-02 | International Flavors & Fragrances Inc. | Oral sensory perception-affecting compositions containing dimethyl sulfoxide, complexes thereof and salts thereof |
| WO2013121407A1 (en) * | 2012-02-17 | 2013-08-22 | Budhi Haryanto | The composition of malodor removing aerosol for daily worn objects or items |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3527864A (en) * | 1966-11-18 | 1970-09-08 | Procter & Gamble | Compositions for topical application to animal tissue and method of enhancing penetration thereof |
-
1972
- 1972-10-24 GB GB4903972A patent/GB1432354A/en not_active Expired
-
1973
- 1973-07-10 DE DE19732334985 patent/DE2334985A1/de active Pending
- 1973-07-13 IL IL42735A patent/IL42735A/en unknown
- 1973-07-16 AT AT626273A patent/AT330362B/de not_active IP Right Cessation
- 1973-07-17 HU HUWI234A patent/HU167694B/hu unknown
- 1973-07-18 LU LU68036A patent/LU68036A1/xx unknown
- 1973-07-18 EG EG282/73A patent/EG10911A/xx active
- 1973-07-18 CH CH1053373A patent/CH576240A5/xx not_active IP Right Cessation
- 1973-07-18 NL NL7310022A patent/NL7310022A/xx unknown
- 1973-07-19 FR FR7326588A patent/FR2193603B1/fr not_active Expired
- 1973-07-19 JP JP48082538A patent/JPS4985245A/ja active Pending
- 1973-07-19 RO RO7375536A patent/RO67322A2/ro unknown
- 1973-07-20 IE IE1237/73A patent/IE37935B1/xx unknown
- 1973-07-20 DD DD172413A patent/DD105390A5/xx unknown
- 1973-07-20 IT IT26885/73A patent/IT1048130B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| ATA626273A (de) | 1975-09-15 |
| GB1432354A (en) | 1976-04-14 |
| RO67322A2 (ro) | 1982-09-09 |
| FR2193603A1 (en:Method) | 1974-02-22 |
| FR2193603B1 (en:Method) | 1977-07-15 |
| IT1048130B (it) | 1980-11-20 |
| IE37935L (en) | 1974-01-20 |
| DE2334985A1 (de) | 1974-02-07 |
| AU5802073A (en) | 1975-01-16 |
| EG10911A (en) | 1976-10-31 |
| CH576240A5 (en:Method) | 1976-06-15 |
| DD105390A5 (en:Method) | 1974-04-20 |
| IE37935B1 (en) | 1977-11-23 |
| AT330362B (de) | 1976-06-25 |
| HU167694B (en:Method) | 1975-11-28 |
| IL42735A0 (en) | 1973-10-25 |
| LU68036A1 (en:Method) | 1973-09-26 |
| NL7310022A (en:Method) | 1974-01-22 |
| JPS4985245A (en:Method) | 1974-08-15 |
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