IL41085A - Phenylacetoxy-c3-6-alkyl-penicillins,their manufacture and pharmaceutical compositions containing them - Google Patents
Phenylacetoxy-c3-6-alkyl-penicillins,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL41085A IL41085A IL41085A IL4108572A IL41085A IL 41085 A IL41085 A IL 41085A IL 41085 A IL41085 A IL 41085A IL 4108572 A IL4108572 A IL 4108572A IL 41085 A IL41085 A IL 41085A
- Authority
- IL
- Israel
- Prior art keywords
- salts
- compounds
- chemical equivalent
- group
- whenever prepared
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 25
- 238000000034 method Methods 0.000 claims abstract 20
- 150000001875 compounds Chemical class 0.000 claims abstract 12
- 150000004677 hydrates Chemical class 0.000 claims abstract 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract 5
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 4
- 125000005843 halogen group Chemical group 0.000 claims abstract 4
- 230000003115 biocidal effect Effects 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims 12
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 6
- 239000011734 sodium Substances 0.000 claims 6
- 229910052708 sodium Inorganic materials 0.000 claims 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 5
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 4
- -1 o-methoxyphenyl Chemical group 0.000 claims 4
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical class OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 claims 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH43572A CH565801A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-01-12 | 1972-01-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41085A0 IL41085A0 (en) | 1973-02-28 |
| IL41085A true IL41085A (en) | 1976-01-30 |
Family
ID=4186954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41085A IL41085A (en) | 1972-01-12 | 1972-12-14 | Phenylacetoxy-c3-6-alkyl-penicillins,their manufacture and pharmaceutical compositions containing them |
Country Status (11)
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754141A (fr) * | 1969-08-04 | 1971-02-01 | Pfizer | Esters d'alpha-carboxyarylmethyl penicillines |
| CH545316A (de) * | 1970-07-17 | 1973-12-15 | Hoffmann La Roche | Verfahren zur Herstellung von Acylderivaten |
-
0
- BE BE793886D patent/BE793886A/xx unknown
-
1972
- 1972-01-12 CH CH43572A patent/CH565801A5/xx not_active IP Right Cessation
- 1972-12-12 ZA ZA728758A patent/ZA728758B/xx unknown
- 1972-12-14 AU AU50095/72A patent/AU462377B2/en not_active Expired
- 1972-12-14 IL IL41085A patent/IL41085A/en unknown
- 1972-12-27 US US318738A patent/US3917584A/en not_active Expired - Lifetime
-
1973
- 1973-01-08 NL NL7300234A patent/NL7300234A/xx unknown
- 1973-01-10 JP JP48005357A patent/JPS4880588A/ja active Pending
- 1973-01-11 GB GB160373A patent/GB1348120A/en not_active Expired
- 1973-01-11 FR FR7300867A patent/FR2181663B1/fr not_active Expired
- 1973-01-12 DE DE2301543A patent/DE2301543A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU462377B2 (en) | 1975-06-26 |
| US3917584A (en) | 1975-11-04 |
| ZA728758B (en) | 1973-08-29 |
| JPS4880588A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-10-29 |
| GB1348120A (en) | 1974-03-13 |
| DE2301543A1 (de) | 1973-07-19 |
| FR2181663B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-10-10 |
| AU5009572A (en) | 1974-06-20 |
| BE793886A (fr) | 1973-07-11 |
| CH565801A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-08-29 |
| FR2181663A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-12-07 |
| NL7300234A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-07-16 |
| IL41085A0 (en) | 1973-02-28 |
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