IL39890A - Xanthone carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them - Google Patents
Xanthone carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL39890A IL39890A IL3989072A IL3989072A IL39890A IL 39890 A IL39890 A IL 39890A IL 3989072 A IL3989072 A IL 3989072A IL 3989072 A IL3989072 A IL 3989072A IL 39890 A IL39890 A IL 39890A
- Authority
- IL
- Israel
- Prior art keywords
- compound according
- carboxylic acid
- xanthone
- hydrogen
- alkyl
- Prior art date
Links
- -1 Xanthone carboxylic acids Chemical class 0.000 title claims 8
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone powder Natural products C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000005907 alkyl ester group Chemical group 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 230000007062 hydrolysis Effects 0.000 claims 5
- 238000006460 hydrolysis reaction Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 231100000252 nontoxic Toxicity 0.000 claims 4
- 230000003000 nontoxic effect Effects 0.000 claims 4
- 230000001590 oxidative effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 239000007858 starting material Substances 0.000 claims 3
- JNPRWSKMJDGYAN-UHFFFAOYSA-N 9-oxoxanthene-2-carboxylic acid Chemical compound C1=CC=C2C(=O)C3=CC(C(=O)O)=CC=C3OC2=C1 JNPRWSKMJDGYAN-UHFFFAOYSA-N 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 208000030961 allergic reaction Diseases 0.000 claims 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 claims 2
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 claims 2
- 229940112669 cuprous oxide Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- SYMSHCCNDCDLPA-UHFFFAOYSA-N 9h-xanthene-2-carboxylic acid Chemical compound C1=CC=C2CC3=CC(C(=O)O)=CC=C3OC2=C1 SYMSHCCNDCDLPA-UHFFFAOYSA-N 0.000 claims 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 1
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 claims 1
- 239000007818 Grignard reagent Substances 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229940117975 chromium trioxide Drugs 0.000 claims 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 claims 1
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/86—Oxygen atoms, e.g. xanthones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16269671A | 1971-07-14 | 1971-07-14 | |
| US217383A US3873714A (en) | 1971-07-14 | 1972-01-12 | Xanthone carboxylic acids and derivatives |
| US00259853A US3818042A (en) | 1972-01-12 | 1972-06-05 | Xanthone carboxylic acids and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL39890A true IL39890A (en) | 1976-02-29 |
Family
ID=27388786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL3989072A IL39890A (en) | 1971-07-14 | 1972-07-12 | Xanthone carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT326121B (de) |
| BE (1) | BE786169A (de) |
| CH (1) | CH580093A5 (de) |
| DE (1) | DE2234256A1 (de) |
| DK (1) | DK141096B (de) |
| ES (6) | ES404786A1 (de) |
| FR (1) | FR2145654B1 (de) |
| GB (1) | GB1386436A (de) |
| IL (1) | IL39890A (de) |
| NL (1) | NL7209628A (de) |
| SE (1) | SE388421B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4242267A (en) | 1980-02-04 | 1980-12-30 | Roussel Uclaf | Process for preparing 5-alkyl-7-(S-alkyl-sulfonimidoyl)-xanthone-2-carboxylic acids |
| US4585876A (en) * | 1982-11-25 | 1986-04-29 | Ciba-Geigy Corporation | Novel xanthones and thioxanthones |
-
0
- BE BE786169D patent/BE786169A/xx unknown
-
1972
- 1972-07-12 AT AT599372A patent/AT326121B/de not_active IP Right Cessation
- 1972-07-12 NL NL7209628A patent/NL7209628A/xx unknown
- 1972-07-12 CH CH1045672A patent/CH580093A5/xx not_active IP Right Cessation
- 1972-07-12 IL IL3989072A patent/IL39890A/en unknown
- 1972-07-12 DE DE19722234256 patent/DE2234256A1/de active Pending
- 1972-07-12 ES ES404786A patent/ES404786A1/es not_active Expired
- 1972-07-12 GB GB3253372A patent/GB1386436A/en not_active Expired
- 1972-07-12 FR FR7225353A patent/FR2145654B1/fr not_active Expired
- 1972-07-12 SE SE919672A patent/SE388421B/xx unknown
- 1972-07-12 DK DK347772A patent/DK141096B/da unknown
-
1975
- 1975-03-15 ES ES435670A patent/ES435670A1/es not_active Expired
- 1975-03-15 ES ES435671A patent/ES435671A1/es not_active Expired
- 1975-03-15 ES ES435673A patent/ES435673A1/es not_active Expired
- 1975-03-15 ES ES435672A patent/ES435672A1/es not_active Expired
- 1975-03-15 ES ES435669A patent/ES435669A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2145654A1 (de) | 1973-02-23 |
| GB1386436A (en) | 1975-03-05 |
| AT326121B (de) | 1975-11-25 |
| DK141096B (da) | 1980-01-14 |
| CH580093A5 (de) | 1976-09-30 |
| AU4445672A (en) | 1974-01-17 |
| FR2145654B1 (de) | 1975-06-20 |
| ES404786A1 (es) | 1976-01-01 |
| NL7209628A (de) | 1973-01-16 |
| ES435672A1 (es) | 1977-05-01 |
| SE388421B (sv) | 1976-10-04 |
| ATA599372A (de) | 1975-02-15 |
| BE786169A (fr) | 1973-01-12 |
| DK141096C (de) | 1980-07-14 |
| ES435670A1 (es) | 1977-05-01 |
| DE2234256A1 (de) | 1973-01-25 |
| ES435671A1 (es) | 1977-05-01 |
| ES435669A1 (es) | 1977-05-01 |
| ES435673A1 (es) | 1977-07-01 |
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