IL39369A - Preparation of 4-aminoquinazoline derivatives,certain such compounds and pharmaceutical compositions containing the - Google Patents
Preparation of 4-aminoquinazoline derivatives,certain such compounds and pharmaceutical compositions containing theInfo
- Publication number
- IL39369A IL39369A IL39369A IL3936972A IL39369A IL 39369 A IL39369 A IL 39369A IL 39369 A IL39369 A IL 39369A IL 3936972 A IL3936972 A IL 3936972A IL 39369 A IL39369 A IL 39369A
- Authority
- IL
- Israel
- Prior art keywords
- quaternary ammonium
- acid addition
- derivatives
- heterocyclic ring
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 3
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 101001113857 Naja kaouthia Acidic phospholipase A2 2 Proteins 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Claims (1)
1. CLAIMS process for the preparation of a of the general wherein the phenyl ring may carry one or more substituents selected from halogen atoms lower alkyl and lower alkoxy the total number of carbon atoms in the alkyl alkoxy substituents being not more than and R represents a di alkyDamxno group or a 5 to saturated heterocyclic ring linked to the quinazolyl nucleus through a nitrogen atom or a 5 to saturated or unsaturated mononuclear heterocyclic ring linked to the quinazolyl nucleus through a carbon said heterocyclic ring containing a oxygen or sulphur atom and optionally a second nitrogen hetero atom and optionally carrying one or more lower alkyl substituents when it contains a second nitrogen hetero atom not directly linked to the quinazolyl an or furoyl substituent which process comprises reacting an of the general wherein the phenyl ring may be substituted as defined CM III R has the meaning as above in the presence a basic the intermediate the l wherein the phenyl ring may be substituted as defined in Claim 1 and are the same or different and each lower group or and together with the nitrogen to they are attached form a 5 to or unsaturated heterocyclic ring which may contain a further hetero selected from Process according to Claim 5 in which the reaction is performed at a temperature between 30 and derivatives of the general formula wherein represents a pyrrolidinyl furyl or furoyl and Rg are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group having not more than four carbon atoms provided that does not represent a group when and Rg are each derivatives accordingxto Claim 7 in which represents a pyridyl or furyl derivatives according to Claim 8 in which represents a The compound quinazoline and its addition and quaternary ammonium salts derivatives according to Claim 8 in which represents a The compound and its acid addition and quaternary ammonium derivatives according to in which represents a The and its acid addition and quaternary ammonium Pharmaceutical composition comprising as active ingredient a compound of formula VII in Claim or a acid addition or quaternary ammonium sal in association with a pharmaceutically acceptabl Animal compositions a nutritionally animal feed containing a derivative formula VII Claim or acid addition or quaternary ammonium salt insufficientOCRQuality
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1380271A GB1390014A (en) | 1971-05-07 | 1971-05-07 | Process for the preparation of carbocyclic fused pyrimidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL39369A0 IL39369A0 (en) | 1972-07-26 |
| IL39369A true IL39369A (en) | 1976-12-31 |
Family
ID=10029665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL39369A IL39369A (en) | 1971-05-07 | 1972-05-05 | Preparation of 4-aminoquinazoline derivatives,certain such compounds and pharmaceutical compositions containing the |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS561315B1 (en) |
| DK (1) | DK130791B (en) |
| IL (1) | IL39369A (en) |
| NO (1) | NO139270C (en) |
-
1972
- 1972-05-03 DK DK219772AA patent/DK130791B/en unknown
- 1972-05-04 JP JP4451272A patent/JPS561315B1/ja active Pending
- 1972-05-05 NO NO1600/72A patent/NO139270C/en unknown
- 1972-05-05 IL IL39369A patent/IL39369A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO139270C (en) | 1979-01-31 |
| DK130791B (en) | 1975-04-14 |
| IL39369A0 (en) | 1972-07-26 |
| JPS561315B1 (en) | 1981-01-13 |
| NO139270B (en) | 1978-10-23 |
| DK130791C (en) | 1975-09-08 |
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