IL39369A - Preparation of 4-aminoquinazoline derivatives,certain such compounds and pharmaceutical compositions containing the - Google Patents

Claims (1)

1. CLAIMS process for the preparation of a of the general wherein the phenyl ring may carry one or more substituents selected from halogen atoms lower alkyl and lower alkoxy the total number of carbon atoms in the alkyl alkoxy substituents being not more than and R represents a di alkyDamxno group or a 5 to saturated heterocyclic ring linked to the quinazolyl nucleus through a nitrogen atom or a 5 to saturated or unsaturated mononuclear heterocyclic ring linked to the quinazolyl nucleus through a carbon said heterocyclic ring containing a oxygen or sulphur atom and optionally a second nitrogen hetero atom and optionally carrying one or more lower alkyl substituents when it contains a second nitrogen hetero atom not directly linked to the quinazolyl an or furoyl substituent which process comprises reacting an of the general wherein the phenyl ring may be substituted as defined CM III R has the meaning as above in the presence a basic the intermediate the l wherein the phenyl ring may be substituted as defined in Claim 1 and are the same or different and each lower group or and together with the nitrogen to they are attached form a 5 to or unsaturated heterocyclic ring which may contain a further hetero selected from Process according to Claim 5 in which the reaction is performed at a temperature between 30 and derivatives of the general formula wherein represents a pyrrolidinyl furyl or furoyl and Rg are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group having not more than four carbon atoms provided that does not represent a group when and Rg are each derivatives accordingxto Claim 7 in which represents a pyridyl or furyl derivatives according to Claim 8 in which represents a The compound quinazoline and its addition and quaternary ammonium salts derivatives according to Claim 8 in which represents a The compound and its acid addition and quaternary ammonium derivatives according to in which represents a The and its acid addition and quaternary ammonium Pharmaceutical composition comprising as active ingredient a compound of formula VII in Claim or a acid addition or quaternary ammonium sal in association with a pharmaceutically acceptabl Animal compositions a nutritionally animal feed containing a derivative formula VII Claim or acid addition or quaternary ammonium salt insufficientOCRQuality