IL37638A - Process for separating citric acid - Google Patents
Process for separating citric acidInfo
- Publication number
- IL37638A IL37638A IL37638A IL3763871A IL37638A IL 37638 A IL37638 A IL 37638A IL 37638 A IL37638 A IL 37638A IL 3763871 A IL3763871 A IL 3763871A IL 37638 A IL37638 A IL 37638A
- Authority
- IL
- Israel
- Prior art keywords
- acid
- citric acid
- isocitric
- citric
- sulfuric acid
- Prior art date
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title description 241
- 238000000034 method Methods 0.000 title description 10
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 84
- 229960004106 citric acid Drugs 0.000 description 79
- ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 61
- 239000013078 crystal Substances 0.000 description 24
- 239000007864 aqueous solution Substances 0.000 description 20
- 238000002425 crystallisation Methods 0.000 description 16
- 230000008025 crystallization Effects 0.000 description 16
- 239000000706 filtrate Substances 0.000 description 15
- 239000012452 mother liquor Substances 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000000243 solution Substances 0.000 description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- ODBLHEXUDAPZAU-ZAFYKAAXSA-N D-threo-isocitric acid Chemical compound OC(=O)[C@H](O)[C@@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-ZAFYKAAXSA-N 0.000 description 6
- ODBLHEXUDAPZAU-FONMRSAGSA-N Isocitric acid Natural products OC(=O)[C@@H](O)[C@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-FONMRSAGSA-N 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 229910002091 carbon monoxide Inorganic materials 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 150000004682 monohydrates Chemical class 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- 210000005253 yeast cell Anatomy 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- 241000222173 Candida parapsilosis Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 229920001429 chelating resin Polymers 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- -1 Candida lipolytica Natural products 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 241000235035 Debaryomyces Species 0.000 description 1
- 241000235048 Meyerozyma guilliermondii Species 0.000 description 1
- 241001193070 Wickerhamomyces subpelliculosus Species 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 241000191335 [Candida] intermedia Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229940055022 candida parapsilosis Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- APVPOHHVBBYQAV-UHFFFAOYSA-N n-(4-aminophenyl)sulfonyloctadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 APVPOHHVBBYQAV-UHFFFAOYSA-N 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/48—Tricarboxylic acids, e.g. citric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8024670 | 1970-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL37638A0 IL37638A0 (en) | 1971-11-29 |
| IL37638A true IL37638A (en) | 1974-07-31 |
Family
ID=13712949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL37638A IL37638A (en) | 1970-09-11 | 1971-09-02 | Process for separating citric acid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3799980A (show.php) |
| AU (1) | AU458747B2 (show.php) |
| BE (1) | BE772474A (show.php) |
| CA (1) | CA960691A (show.php) |
| DE (1) | DE2145084C3 (show.php) |
| FR (1) | FR2107571A5 (show.php) |
| GB (1) | GB1365362A (show.php) |
| IE (1) | IE35629B1 (show.php) |
| IL (1) | IL37638A (show.php) |
| IT (1) | IT945760B (show.php) |
| NL (1) | NL173284C (show.php) |
| ZA (1) | ZA716088B (show.php) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139556A (en) * | 1976-04-29 | 1979-02-13 | Chevron Research Company | Mono-ol from diol and improved citric acid process |
| KR101274369B1 (ko) * | 2008-06-20 | 2013-06-13 | 아사히 가세이 케미칼즈 가부시키가이샤 | α-히드록시산의 제조 방법 |
-
1971
- 1971-09-02 IL IL37638A patent/IL37638A/en unknown
- 1971-09-08 IE IE1145/71A patent/IE35629B1/xx unknown
- 1971-09-09 DE DE2145084A patent/DE2145084C3/de not_active Expired
- 1971-09-09 GB GB4204671A patent/GB1365362A/en not_active Expired
- 1971-09-09 AU AU33306/71A patent/AU458747B2/en not_active Expired
- 1971-09-10 IT IT70005/71A patent/IT945760B/it active
- 1971-09-10 NL NLAANVRAGE7112484,A patent/NL173284C/xx not_active IP Right Cessation
- 1971-09-10 CA CA122,531A patent/CA960691A/en not_active Expired
- 1971-09-10 US US00179412A patent/US3799980A/en not_active Expired - Lifetime
- 1971-09-10 FR FR7132831A patent/FR2107571A5/fr not_active Expired
- 1971-09-10 BE BE772474A patent/BE772474A/xx not_active IP Right Cessation
- 1971-09-10 ZA ZA716088A patent/ZA716088B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3330671A (en) | 1973-03-15 |
| IE35629B1 (en) | 1976-04-14 |
| DE2145084C3 (de) | 1981-07-02 |
| NL173284B (nl) | 1983-08-01 |
| IT945760B (it) | 1973-05-10 |
| CA960691A (en) | 1975-01-07 |
| FR2107571A5 (show.php) | 1972-05-05 |
| US3799980A (en) | 1974-03-26 |
| NL173284C (nl) | 1984-01-02 |
| IE35629L (en) | 1972-03-11 |
| GB1365362A (en) | 1974-09-04 |
| NL7112484A (show.php) | 1972-03-14 |
| DE2145084B2 (de) | 1980-11-20 |
| DE2145084A1 (de) | 1972-03-16 |
| ZA716088B (en) | 1972-05-31 |
| IL37638A0 (en) | 1971-11-29 |
| AU458747B2 (en) | 1975-03-06 |
| BE772474A (fr) | 1972-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1995003268A1 (en) | Process for recovering organic acids | |
| US3086928A (en) | Process of producing citric acid | |
| US3904684A (en) | Method for producing sodium citrate dihydrate | |
| US3253023A (en) | Recovery of 3-(3, 4-dihydroxyphenyl)-l-alanine from velvet beans | |
| IL37638A (en) | Process for separating citric acid | |
| US3391187A (en) | Purification of malic acid | |
| US5202476A (en) | Purification of 2-keto-L-gulonic acid | |
| DE3400574A1 (de) | Verfahren zur isolierung von l-aminosaeuren | |
| US2918492A (en) | Method of preparing methyl 2-ketogluconate | |
| JPS6338B2 (show.php) | ||
| US2929839A (en) | Process for recovering glutamic acid | |
| US3037973A (en) | Tetracycline recovery process | |
| US3366681A (en) | Process for the recovery of methionine | |
| US3360554A (en) | Process for crystallizing out l-glutamic acid | |
| US3205261A (en) | Method for separation of glutamic acid | |
| US3381027A (en) | Preparation and recovery of methyl 2-ketogluconate | |
| US3925465A (en) | Crystallization of alpha monosodium citrate monohydrate | |
| JPH034532B2 (show.php) | ||
| US3172830A (en) | Koh ore | |
| USRE28203E (en) | Process of producing citric acid | |
| US2331948A (en) | Method for the purification of lactic acid | |
| US3817718A (en) | Process for the recovery of ammonium sulphate from an aqueous ammonium sulphate solution containing methionine | |
| US2796434A (en) | Recovery of glutamic acid values | |
| US3206506A (en) | Separation of acetylglutamine | |
| EP0174142A2 (en) | Recovery of squaric acid |