IL34387A - Methods for diagnosing blood using radioactive markers and ion exchange resin membranes - Google Patents
Methods for diagnosing blood using radioactive markers and ion exchange resin membranesInfo
- Publication number
- IL34387A IL34387A IL34387A IL3438770A IL34387A IL 34387 A IL34387 A IL 34387A IL 34387 A IL34387 A IL 34387A IL 3438770 A IL3438770 A IL 3438770A IL 34387 A IL34387 A IL 34387A
- Authority
- IL
- Israel
- Prior art keywords
- thyroxine
- serum
- radioactive
- membrane
- blood serum
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims description 44
- 239000000700 radioactive tracer Substances 0.000 title claims description 32
- 150000001875 compounds Chemical class 0.000 title claims description 31
- 239000003456 ion exchange resin Substances 0.000 title claims description 18
- 229920003303 ion-exchange polymer Polymers 0.000 title claims description 18
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 title claims description 17
- 210000004369 blood Anatomy 0.000 title claims description 10
- 239000008280 blood Substances 0.000 title claims description 10
- 238000002405 diagnostic procedure Methods 0.000 title description 3
- 210000002966 serum Anatomy 0.000 claims description 73
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 63
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 59
- 229940034208 thyroxine Drugs 0.000 claims description 59
- 239000011347 resin Substances 0.000 claims description 34
- 229920005989 resin Polymers 0.000 claims description 34
- 239000000523 sample Substances 0.000 claims description 34
- 239000000243 solution Substances 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
- 230000002285 radioactive effect Effects 0.000 claims description 30
- 102000004506 Blood Proteins Human genes 0.000 claims description 21
- 108010017384 Blood Proteins Proteins 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 102000006395 Globulins Human genes 0.000 claims description 13
- 108010044091 Globulins Proteins 0.000 claims description 13
- 239000003153 chemical reaction reagent Substances 0.000 claims description 13
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 7
- 239000011630 iodine Substances 0.000 claims description 7
- 229910052740 iodine Inorganic materials 0.000 claims description 7
- 210000001685 thyroid gland Anatomy 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 6
- PNDPGZBMCMUPRI-XXSWNUTMSA-N [125I][125I] Chemical compound [125I][125I] PNDPGZBMCMUPRI-XXSWNUTMSA-N 0.000 claims description 5
- 238000000338 in vitro Methods 0.000 claims description 5
- 229940044173 iodine-125 Drugs 0.000 claims description 5
- 102000002248 Thyroxine-Binding Globulin Human genes 0.000 claims description 4
- 108010000259 Thyroxine-Binding Globulin Proteins 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 4
- 239000012675 alcoholic extract Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 claims description 3
- FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 claims description 3
- 239000013068 control sample Substances 0.000 claims description 3
- 229960004642 ferric ammonium citrate Drugs 0.000 claims description 3
- 239000004313 iron ammonium citrate Substances 0.000 claims description 3
- 235000000011 iron ammonium citrate Nutrition 0.000 claims description 3
- 102000009027 Albumins Human genes 0.000 claims description 2
- 108010088751 Albumins Proteins 0.000 claims description 2
- XEEYBQQBJWHFJM-AKLPVKDBSA-N Iron-59 Chemical compound [59Fe] XEEYBQQBJWHFJM-AKLPVKDBSA-N 0.000 claims description 2
- 102000007584 Prealbumin Human genes 0.000 claims description 2
- 108010071690 Prealbumin Proteins 0.000 claims description 2
- 239000003957 anion exchange resin Substances 0.000 claims description 2
- 239000002657 fibrous material Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000008366 buffered solution Substances 0.000 claims 3
- 125000003010 ionic group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 102100028709 Thyroxine-binding globulin Human genes 0.000 description 18
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 8
- 238000011534 incubation Methods 0.000 description 7
- 150000001450 anions Chemical class 0.000 description 6
- 229910052742 iron Inorganic materials 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 5
- 239000007982 barbital buffer Substances 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 229960002319 barbital Drugs 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229920002466 Dynel Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 229960000796 barbital sodium Drugs 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000003014 ion exchange membrane Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000005495 thyroid hormone Substances 0.000 description 2
- 229940036555 thyroid hormone Drugs 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 241000736355 Euthyroides Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000009488 Thyroxine-Binding Proteins Human genes 0.000 description 1
- 108010048889 Thyroxine-Binding Proteins Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- -1 iodine-125 Chemical compound 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82109769A | 1969-05-01 | 1969-05-01 | |
| US86578569A | 1969-10-13 | 1969-10-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL34387A0 IL34387A0 (en) | 1970-06-17 |
| IL34387A true IL34387A (en) | 1973-04-30 |
Family
ID=27124511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL34387A IL34387A (en) | 1969-05-01 | 1970-04-24 | Methods for diagnosing blood using radioactive markers and ion exchange resin membranes |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3714344A (enExample) |
| JP (2) | JPS5617620B1 (enExample) |
| BE (1) | BE749772A (enExample) |
| CH (1) | CH526781A (enExample) |
| DE (1) | DE2021968A1 (enExample) |
| FR (1) | FR2047211A5 (enExample) |
| GB (1) | GB1314263A (enExample) |
| IL (1) | IL34387A (enExample) |
| IT (1) | IT943545B (enExample) |
| NL (2) | NL7006455A (enExample) |
| SE (1) | SE378679B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911096A (en) * | 1972-06-23 | 1975-10-07 | Professional Staff Ass Of The | Radioimmunoassay for measurement of thyroxine (T{HD 4{B ) and triiodothyonine (T{HD 3{B ) in blood serum |
| USRE32098E (en) * | 1972-06-23 | 1986-03-25 | Research And Education Institute, Inc. | Radioimmunoassay for measurement of thyroxine (T4) and triiodothyronine (T3) in blood serum |
| US3966897A (en) * | 1973-04-02 | 1976-06-29 | Marine Colloids, Inc. | Medium for use in bioassay and method of using same |
| GB1412274A (en) * | 1973-05-29 | 1975-11-05 | Bio Rad Laboratories | Radioactive determination of serum thyroxine |
| US3929981A (en) * | 1974-02-27 | 1975-12-30 | Squibb & Sons Inc | Method for determining thyroid function |
| CA1050425A (en) * | 1975-06-26 | 1979-03-13 | Mallinckrodt | Radioimmunoassay methods for the determination of l-triiodothyronine and thyroxine |
| US4289748A (en) * | 1979-05-31 | 1981-09-15 | United States Of America | Ultrasensitive enzymatic radioimmunoassay method |
| US4282002A (en) * | 1979-09-06 | 1981-08-04 | Akzona Incorporated | Sensitized sheep stroma immunoassay for rheumatoid factor |
| US6242261B1 (en) | 1992-02-10 | 2001-06-05 | University Of Saskatchewan | Assessment of ion availability in heterogeneous media using ion-exchange membranes |
| US5352803A (en) * | 1992-03-30 | 1994-10-04 | Abbott Laboratories | 5(6)-methyl substituted fluorescein derivatives |
| CA2131727A1 (en) * | 1992-03-30 | 1993-10-14 | Diana E. Clarisse | Reagents and methods for the detection and quantification of thyroxine in fluid samples |
| FR2878333B1 (fr) * | 2004-11-25 | 2007-04-27 | Cie Gen De S Eaux Soc En Comma | Mallette pour le prelevement d'eau et la capture de substances generatrices d'odeurs et/ou de gouts presents dans l'eau |
| US11768689B2 (en) | 2013-08-08 | 2023-09-26 | Movidius Limited | Apparatus, systems, and methods for low power computational imaging |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3414383A (en) * | 1965-08-09 | 1968-12-03 | Canadian Patents Dev | Determination of thyroxine |
-
1969
- 1969-10-13 US US00865785A patent/US3714344A/en not_active Expired - Lifetime
-
1970
- 1970-04-22 GB GB1939170A patent/GB1314263A/en not_active Expired
- 1970-04-24 IL IL34387A patent/IL34387A/en unknown
- 1970-04-27 DE DE19702021968 patent/DE2021968A1/de active Pending
- 1970-04-28 SE SE7005892A patent/SE378679B/xx unknown
- 1970-04-28 IT IT50306/70A patent/IT943545B/it active
- 1970-04-30 FR FR7016059A patent/FR2047211A5/fr not_active Expired
- 1970-04-30 BE BE749772D patent/BE749772A/xx unknown
- 1970-05-01 JP JP3743570A patent/JPS5617620B1/ja active Pending
- 1970-05-01 NL NL7006455A patent/NL7006455A/xx unknown
- 1970-05-01 CH CH660670A patent/CH526781A/de not_active IP Right Cessation
-
1974
- 1974-12-31 NL NL7417037A patent/NL7417037A/xx unknown
-
1976
- 1976-01-30 JP JP917876A patent/JPS5542704B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BE749772A (fr) | 1970-10-30 |
| NL7006455A (enExample) | 1970-11-03 |
| IL34387A0 (en) | 1970-06-17 |
| JPS5617620B1 (enExample) | 1981-04-23 |
| FR2047211A5 (enExample) | 1971-03-12 |
| IT943545B (it) | 1973-04-10 |
| JPS5542704B1 (enExample) | 1980-11-01 |
| CH526781A (de) | 1972-08-15 |
| SE378679B (enExample) | 1975-09-08 |
| GB1314263A (en) | 1973-04-18 |
| US3714344A (en) | 1973-01-30 |
| NL7417037A (nl) | 1975-04-29 |
| DE2021968A1 (de) | 1970-11-05 |
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