IL33846A - Derivatives of 1-thiachromone and 4-thionchromone,their preparation and pharmaceutical compositions containing them - Google Patents
Derivatives of 1-thiachromone and 4-thionchromone,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL33846A IL33846A IL33846A IL3384670A IL33846A IL 33846 A IL33846 A IL 33846A IL 33846 A IL33846 A IL 33846A IL 3384670 A IL3384670 A IL 3384670A IL 33846 A IL33846 A IL 33846A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- carbon
- pharmaceutically acceptable
- group containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- DHSYDTXGFJPXKA-UHFFFAOYSA-N thiochromen-4-one Chemical class C1=CC=C2C(=O)C=CSC2=C1 DHSYDTXGFJPXKA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 22
- 239000000203 mixture Substances 0.000 claims abstract 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 6
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 5
- 150000001408 amides Chemical class 0.000 claims abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 5
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims abstract 3
- 238000006243 chemical reaction Methods 0.000 claims abstract 3
- 150000002148 esters Chemical class 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 239000005864 Sulphur Substances 0.000 claims 2
- 150000001263 acyl chlorides Chemical group 0.000 claims 2
- -1 alkali metal cation Chemical class 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 241000237519 Bivalvia Species 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 235000020639 clam Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- HUYWAWARQUIQLE-UHFFFAOYSA-N Isoetharine Chemical compound CC(C)NC(CC)C(O)C1=CC=C(O)C(O)=C1 HUYWAWARQUIQLE-UHFFFAOYSA-N 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 229960001268 isoetarine Drugs 0.000 abstract 1
- 229960001317 isoprenaline Drugs 0.000 abstract 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 abstract 1
- 229960002657 orciprenaline Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7467/69A GB1291864A (en) | 1969-02-12 | 1969-02-12 | Mono thiachromone-2-carboxylic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL33846A0 IL33846A0 (en) | 1970-04-20 |
| IL33846A true IL33846A (en) | 1976-04-30 |
Family
ID=9833661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL33846A IL33846A (en) | 1969-02-12 | 1970-02-05 | Derivatives of 1-thiachromone and 4-thionchromone,their preparation and pharmaceutical compositions containing them |
Country Status (9)
| Country | Link |
|---|---|
| JP (2) | JPS4835266B1 (enrdf_load_html_response) |
| CH (5) | CH557811A (enrdf_load_html_response) |
| DE (1) | DE2006196A1 (enrdf_load_html_response) |
| DK (1) | DK128420B (enrdf_load_html_response) |
| FR (1) | FR2034538B1 (enrdf_load_html_response) |
| GB (1) | GB1291864A (enrdf_load_html_response) |
| IL (1) | IL33846A (enrdf_load_html_response) |
| NL (1) | NL7001922A (enrdf_load_html_response) |
| SE (1) | SE367634B (enrdf_load_html_response) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1362782A (en) * | 1970-08-26 | 1974-08-07 | Fisons Ltd | Tetrazole derivatives |
| BE769146A (fr) * | 1970-07-01 | 1971-11-03 | Takeda Chemical Industries Ltd | Derives d'acides chromone-carboxylique |
| GB1391615A (en) * | 1971-09-30 | 1975-04-23 | Fisons Ltd | 4-oxo-4h-1-benzopyran and 4-oxo-4h-1-thia benzopyran derivatives |
| JPS50112055U (enrdf_load_html_response) * | 1974-02-22 | 1975-09-12 | ||
| US4159273A (en) * | 1974-11-30 | 1979-06-26 | Fisons Limited | Tricyclic mono-chromone-2-carboxylic acids |
| CA1065329A (en) * | 1974-11-30 | 1979-10-30 | Richard Hazard | Chromone derivatives |
| DE3275295D1 (en) * | 1981-11-12 | 1987-03-05 | Fisons Plc | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them |
| US4665203A (en) * | 1983-08-08 | 1987-05-12 | G. D. Searle & Co. | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors |
| US4778903A (en) * | 1983-12-12 | 1988-10-18 | G. D. Searle & Co. | Substituted dihydrobenzopyrans |
| US4888356A (en) * | 1983-08-08 | 1989-12-19 | G. D. Searle And Company | Use of substituted dihydrobenzopyrans for allergy and inflammation |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| US4644071A (en) * | 1984-07-11 | 1987-02-17 | G. D. Searle & Co. | Aralkoxy and aryloxyalkoxy kojic acid derivatives |
-
1969
- 1969-02-12 GB GB7467/69A patent/GB1291864A/en not_active Expired
-
1970
- 1970-02-05 IL IL33846A patent/IL33846A/en unknown
- 1970-02-10 FR FR7004568A patent/FR2034538B1/fr not_active Expired
- 1970-02-11 CH CH178472A patent/CH557811A/fr not_active IP Right Cessation
- 1970-02-11 SE SE01744/70A patent/SE367634B/xx unknown
- 1970-02-11 DE DE19702006196 patent/DE2006196A1/de active Pending
- 1970-02-11 CH CH178372A patent/CH551438A/fr not_active IP Right Cessation
- 1970-02-11 CH CH178572A patent/CH560712A5/xx not_active IP Right Cessation
- 1970-02-11 CH CH178672A patent/CH557346A/fr not_active IP Right Cessation
- 1970-02-11 NL NL7001922A patent/NL7001922A/xx unknown
- 1970-02-11 DK DK66870AA patent/DK128420B/da unknown
- 1970-02-11 CH CH196970A patent/CH551437A/fr not_active IP Right Cessation
-
1972
- 1972-08-25 JP JP47084683A patent/JPS4835266B1/ja active Pending
- 1972-08-25 JP JP47084684A patent/JPS4835267B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK128420B (da) | 1974-04-29 |
| CH560712A5 (enrdf_load_html_response) | 1975-04-15 |
| NL7001922A (enrdf_load_html_response) | 1970-08-14 |
| JPS4835266B1 (enrdf_load_html_response) | 1973-10-26 |
| CH551438A (fr) | 1974-07-15 |
| FR2034538A1 (enrdf_load_html_response) | 1970-12-11 |
| JPS4835267B1 (enrdf_load_html_response) | 1973-10-26 |
| FR2034538B1 (enrdf_load_html_response) | 1974-08-30 |
| CH551437A (fr) | 1974-07-15 |
| CH557346A (fr) | 1974-12-31 |
| GB1291864A (en) | 1972-10-04 |
| IL33846A0 (en) | 1970-04-20 |
| SE367634B (enrdf_load_html_response) | 1974-06-04 |
| CH557811A (fr) | 1975-01-15 |
| DE2006196A1 (de) | 1970-11-05 |
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