IL327227A - חלבוני איחוי הנקשרים באופן ייחודי לקולטן TNF receptor 2, הכוללים אזורים הומולוגים ל-TNF ואזורי FC מוטנטיים - Google Patents
חלבוני איחוי הנקשרים באופן ייחודי לקולטן TNF receptor 2, הכוללים אזורים הומולוגים ל-TNF ואזורי FC מוטנטייםInfo
- Publication number
- IL327227A IL327227A IL327227A IL32722726A IL327227A IL 327227 A IL327227 A IL 327227A IL 327227 A IL327227 A IL 327227A IL 32722726 A IL32722726 A IL 32722726A IL 327227 A IL327227 A IL 327227A
- Authority
- IL
- Israel
- Prior art keywords
- domains
- tnf
- mutated
- fusion proteins
- specific agonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP23200533 | 2023-09-28 | ||
| PCT/EP2024/077361 WO2025068565A1 (en) | 2023-09-28 | 2024-09-27 | Tnf receptor 2-specific agonist fusion proteins comprising tnf homology domains and mutated fc domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL327227A true IL327227A (he) | 2026-05-01 |
Family
ID=88236510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL327227A IL327227A (he) | 2023-09-28 | 2024-09-27 | חלבוני איחוי הנקשרים באופן ייחודי לקולטן TNF receptor 2, הכוללים אזורים הומולוגים ל-TNF ואזורי FC מוטנטיים |
Country Status (6)
| Country | Link |
|---|---|
| CN (1) | CN122029185A (he) |
| AR (1) | AR133982A1 (he) |
| AU (1) | AU2024351764A1 (he) |
| IL (1) | IL327227A (he) |
| TW (1) | TW202530263A (he) |
| WO (1) | WO2025068565A1 (he) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025072726A1 (en) | 2023-09-29 | 2025-04-03 | Trex Bio, Inc. | Tnf-alpha variant fusion molecules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103249742B (zh) * | 2010-09-16 | 2017-04-12 | 巴利奥医药股份公司 | 抗人肿瘤坏死因子1型受体抗体 |
| WO2020260368A1 (en) | 2019-06-24 | 2020-12-30 | Universität Stuttgart | Tnfr2 agonists with improved stability |
-
2024
- 2024-09-27 IL IL327227A patent/IL327227A/he unknown
- 2024-09-27 TW TW113136946A patent/TW202530263A/zh unknown
- 2024-09-27 WO PCT/EP2024/077361 patent/WO2025068565A1/en active Pending
- 2024-09-27 AR ARP240102635A patent/AR133982A1/es unknown
- 2024-09-27 AU AU2024351764A patent/AU2024351764A1/en active Pending
- 2024-09-27 CN CN202480062289.1A patent/CN122029185A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2024351764A1 (en) | 2026-03-26 |
| TW202530263A (zh) | 2025-08-01 |
| CN122029185A (zh) | 2026-05-12 |
| AR133982A1 (es) | 2025-11-19 |
| WO2025068565A1 (en) | 2025-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5368301B2 (ja) | 可溶性ヘテロ二量体レセプター及びその使用 | |
| Matoba et al. | Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation and the binding of the Wnt antagonist Dkk1 | |
| Baldwin et al. | The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man | |
| Takagi et al. | C-terminal opening mimics' inside-out'activation of integrin α5β1 | |
| ES2661704T3 (es) | Proteínas estables | |
| Gordon et al. | BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site | |
| WO2006031689A3 (en) | Multimeric constructs | |
| JP2018164456A (ja) | Ｇタンパク質共役型受容体変異体及びその選択方法 | |
| CA3305610A1 (en) | Tnf receptor 2-specific agonist fusion proteins comprising tnf homology domains and mutated fc domains | |
| Janssens et al. | αT-catenin: a novel tissue-specific β-catenin-binding protein mediating strong cell-cell adhesion | |
| Fowler et al. | Refinement of a homology model of the μ-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites | |
| Cornelis et al. | Characterization of critical residues in the cytoplasmic domain of the human interleukin‐5 receptor α chain required for growth signal transduction | |
| MX2024013669A (es) | Novedosas proteinas de fusion cd200 | |
| Staebler et al. | Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein | |
| Olosz et al. | Structural basis for binding multiple ligands by the common cytokine receptor γ-chain | |
| Ueda et al. | Cell-growth control by monomeric antigen: the cell surface expression of lysozyme-specific Ig V-domains fused to truncated Epo receptor | |
| Hirsch et al. | A novel A20 (TNFAIP3) antibody (Ber‐A20) can be used to detect unmutated A20 by immunohistology | |
| Quéméner et al. | IL-15Rα membrane anchorage in either cis or trans is required for stabilization of IL-15 and optimal signaling | |
| Brunskole et al. | Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation | |
| Hatakeyama et al. | Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules. | |
| EP4426825A4 (en) | RECOMBINANT/FUSION POLYPEPTIDES COMPRISING A MUTATED ANGIOTENSIN 2-CONVERTING ENZYME (ACE2) | |
| HK40108078A (en) | Fusion protein containing improved glp-1 receptor agonist and uses | |
| Wagner et al. | Inhibition of granulocyte-macrophage colony-stimulating factor receptor function by a splice variant of the common β-receptor subunit | |
| Lee et al. | The binding properties of glycosylated and non-glycosylated tim-3 molecules on CD4+ CD25+ T cells | |
| CA3274469A1 (en) | Fusion gene containing encoding gene of chimeric antigen receptor and encoding gene of chimeric switch receptor and use thereof |