IL326707A - Chimeric antigen receptor constructs and uses thereof - Google Patents

Chimeric antigen receptor constructs and uses thereof

Info

Publication number
IL326707A
IL326707A IL326707A IL32670726A IL326707A IL 326707 A IL326707 A IL 326707A IL 326707 A IL326707 A IL 326707A IL 32670726 A IL32670726 A IL 32670726A IL 326707 A IL326707 A IL 326707A
Authority
IL
Israel
Prior art keywords
antigen receptor
chimeric antigen
receptor constructs
constructs
chimeric
Prior art date
Application number
IL326707A
Other languages
Hebrew (he)
Inventor
Gregor Hutter
Aquino Dos Santos Martins Tomas De
Original Assignee
Univ Basel Vizerektorat Forschung
Gregor Hutter
Aquino Dos Santos Martins Tomas De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Basel Vizerektorat Forschung, Gregor Hutter, Aquino Dos Santos Martins Tomas De filed Critical Univ Basel Vizerektorat Forschung
Publication of IL326707A publication Critical patent/IL326707A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/35—Cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/055—Fusion polypeptide containing a localisation/targetting motif containing a signal for localisation to secretory granules (for exocytosis)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL326707A 2023-08-31 2024-08-29 Chimeric antigen receptor constructs and uses thereof IL326707A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP23194459 2023-08-31
EP24157584 2024-02-14
PCT/EP2024/074131 WO2025045979A1 (en) 2023-08-31 2024-08-29 Chimeric antigen receptor constructs and uses thereof

Publications (1)

Publication Number Publication Date
IL326707A true IL326707A (en) 2026-04-01

Family

ID=92542628

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326707A IL326707A (en) 2023-08-31 2024-08-29 Chimeric antigen receptor constructs and uses thereof

Country Status (3)

Country Link
AU (1) AU2024330614A1 (en)
IL (1) IL326707A (en)
WO (1) WO2025045979A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2994935A1 (en) 2015-05-18 2016-11-24 Ab Initio Biotherapeutics, Inc. Sirp polypeptide compositions and methods of use
BR112022023371A2 (en) * 2020-05-22 2022-12-20 Chongqing Prec Biotech Co Ltd FUSION PROTEIN FOR REVERSING THE TUMOR MICROENVIRONMENT, EXPRESSION VECTOR, IMMUNE CELL, TUMOR IMMUNOSUPPRESSION-RESISTANT CHIMERIC ANTIGEN RECEPTOR, NUCLEIC ACID SEQUENCE, METHOD FOR PREPARING AN IMMUNE CELL, PHARMACEUTICAL COMPOSITION, AND, USE OF THE PHARMACEUTICAL COMPOSITION

Also Published As

Publication number Publication date
AU2024330614A1 (en) 2026-02-05
WO2025045979A1 (en) 2025-03-06

Similar Documents

Publication Publication Date Title
GB2606869B (en) CLL1-Targeting chimeric antigen receptor and application thereof
SG11202101773WA (en) Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof
SG10201913579WA (en) Chimeric antibody/t-cell receptor constructs and uses thereof
SG11202108759SA (en) Humanized anti-dll3 chimeric antigen receptors and uses thereof
IL295381B1 (en) Bcma-directed chimeric antigen receptor t cell compositions and methods and uses thereof
IL287487A (en) Rituximab-resistant chimeric antigen receptors and uses thereof
SG11202010451QA (en) Chimeric antigen receptors with modified linker domains and uses thereof
IL312003A (en) Anti-steap2 chimeric antigen receptors and uses thereof
IL295384B1 (en) Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof
IL318416A (en) Chimeric antigen receptors specific for gprc5d and bcma
IL287156A (en) Humanized anti-folate receptor 1 chimeric antigen receptors and uses thereof
IL321365A (en) Chimeric antigen receptor
EP4265638A4 (en) Chimeric antigen receptor targeting cd123 and use thereof
EP4225799A4 (en) Cd19-directed chimeric antigen receptor constructs
EP4323387A4 (en) Improved chimeric antigen receptors and uses thereof
IL326707A (en) Chimeric antigen receptor constructs and uses thereof
CA3300095A1 (en) Chimeric antigen receptor constructs and uses thereof
EP3892630A4 (en) Human anti-antxr chimeric antigen receptor and use thereof
IL306129A (en) Antigen-binding protein constructs and antibodies and uses thereof
HK40091205A (en) Cd19-directed chimeric antigen receptor constructs
HK40114938A (en) Cd19-targeting chimeric antigen receptor and use thereof
GB202008688D0 (en) Chimeric antigen receptor cell
GB202311746D0 (en) Chimeric antigen receptor
GB202219568D0 (en) Chimeric antigen receptor
HK40107119A (en) Improved chimeric antigen receptors and uses thereof