IL326531A - Cap analogs and methods of use thereof - Google Patents

Cap analogs and methods of use thereof

Info

Publication number
IL326531A
IL326531A IL326531A IL32653126A IL326531A IL 326531 A IL326531 A IL 326531A IL 326531 A IL326531 A IL 326531A IL 32653126 A IL32653126 A IL 32653126A IL 326531 A IL326531 A IL 326531A
Authority
IL
Israel
Prior art keywords
methods
cap analogs
analogs
cap
Prior art date
Application number
IL326531A
Other languages
Hebrew (he)
Inventor
Chunping Xu
Chanfeng Zhao
Alexandre V Lebedev
Ilya Vladimirovich ILICHEV
Hengyuan Lang
Original Assignee
Trilink Biotechnologies Llc
Chunping Xu
Chanfeng Zhao
Alexandre V Lebedev
Ilya Vladimirovich ILICHEV
Hengyuan Lang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trilink Biotechnologies Llc, Chunping Xu, Chanfeng Zhao, Alexandre V Lebedev, Ilya Vladimirovich ILICHEV, Hengyuan Lang filed Critical Trilink Biotechnologies Llc
Publication of IL326531A publication Critical patent/IL326531A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL326531A 2023-09-06 2024-09-06 Cap analogs and methods of use thereof IL326531A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363536844P 2023-09-06 2023-09-06
PCT/US2024/045502 WO2025054401A2 (en) 2023-09-06 2024-09-06 Cap analogs and methods of use thereof

Publications (1)

Publication Number Publication Date
IL326531A true IL326531A (en) 2026-04-01

Family

ID=92895771

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326531A IL326531A (en) 2023-09-06 2024-09-06 Cap analogs and methods of use thereof

Country Status (5)

Country Link
CN (1) CN121794279A (en)
AU (1) AU2024337685A1 (en)
IL (1) IL326531A (en)
TW (1) TW202526022A (en)
WO (1) WO2025054401A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026010855A1 (en) 2024-07-02 2026-01-08 Trilink Biotechnologies, Llc Modified rna for increasing protein expression

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2998800A (en) 1999-03-24 2000-10-09 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The N-acylphosphoramidites and their use in oligonucleotide synthesis
AU2007268075C1 (en) 2006-06-01 2013-03-07 Trilink Biotechnologies Chemically modified oligonucleotide primers for nucleic acid amplification
ES2964690T3 (en) * 2015-09-21 2024-04-09 Trilink Biotechnologies Llc Method for synthesizing 5' capped RNA
PL248416B1 (en) * 2020-02-12 2025-12-08 Explorna Therapeutics Spolka Z Ograniczona Odpowiedzialnoscia New analogs of 5' mRNA end cap, RNA molecule that contains them, their applications and method for synthesis of the RNA molecule and peptide
EP3901261A1 (en) * 2020-04-22 2021-10-27 BioNTech RNA Pharmaceuticals GmbH Coronavirus vaccine
CN116368226A (en) * 2020-09-04 2023-06-30 维乎医疗有限公司 Compositions and methods for capping RNA
KR20220140140A (en) * 2021-04-09 2022-10-18 한미정밀화학주식회사 A capped oligonucleotide primer and use thereof
CN117858885A (en) * 2021-07-05 2024-04-09 国立研究开发法人科学技术振兴机构 Method for purifying nucleotides, device for purifying nucleotides, hydrophobic reagent and hydrophobic substrate
US20250122546A1 (en) * 2021-10-28 2025-04-17 BioNTech SE Rna constructs and uses thereof
JP2025507894A (en) * 2022-03-01 2025-03-21 ヴァーヴ・セラピューティクス，インコーポレーテッド Compositions and methods for capping RNA

Also Published As

Publication number Publication date
WO2025054401A3 (en) 2025-05-08
AU2024337685A1 (en) 2026-02-26
CN121794279A (en) 2026-04-03
WO2025054401A2 (en) 2025-03-13
TW202526022A (en) 2025-07-01

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