IL32637A - שיטה להכנת א9-פלואורו -61-מתילן- פדניסולון ו-12 אסטרים שלהם - Google Patents
שיטה להכנת א9-פלואורו -61-מתילן- פדניסולון ו-12 אסטרים שלהםInfo
- Publication number
- IL32637A IL32637A IL32637A IL3263769A IL32637A IL 32637 A IL32637 A IL 32637A IL 32637 A IL32637 A IL 32637A IL 3263769 A IL3263769 A IL 3263769A IL 32637 A IL32637 A IL 32637A
- Authority
- IL
- Israel
- Prior art keywords
- prednisone
- preparing
- prednisolone
- 9alpha
- fluoro
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 6
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 title description 3
- 229960004618 prednisone Drugs 0.000 title description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 4
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 2
- 150000003118 prednisones Chemical class 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
Landscapes
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL32637A IL32637A (he) | 1969-07-16 | 1969-07-16 | שיטה להכנת א9-פלואורו -61-מתילן- פדניסולון ו-12 אסטרים שלהם |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL32637A IL32637A (he) | 1969-07-16 | 1969-07-16 | שיטה להכנת א9-פלואורו -61-מתילן- פדניסולון ו-12 אסטרים שלהם |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL32637A0 IL32637A0 (en) | 1969-09-25 |
| IL32637A true IL32637A (he) | 1972-11-28 |
Family
ID=11045032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL32637A IL32637A (he) | 1969-07-16 | 1969-07-16 | שיטה להכנת א9-פלואורו -61-מתילן- פדניסולון ו-12 אסטרים שלהם |
Country Status (1)
| Country | Link |
|---|---|
| IL (1) | IL32637A (he) |
-
1969
- 1969-07-16 IL IL32637A patent/IL32637A/he unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL32637A0 (en) | 1969-09-25 |
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