IL326278A - Crystalline form h1 of 5-((3r,55)-3-amino-5- trifluoromethyl-piperidin-1-yl)-quinoline-8-carbonitrile hemihydrate - Google Patents

Crystalline form h1 of 5-((3r,55)-3-amino-5- trifluoromethyl-piperidin-1-yl)-quinoline-8-carbonitrile hemihydrate

Info

Publication number
IL326278A
IL326278A IL326278A IL32627826A IL326278A IL 326278 A IL326278 A IL 326278A IL 326278 A IL326278 A IL 326278A IL 32627826 A IL32627826 A IL 32627826A IL 326278 A IL326278 A IL 326278A
Authority
IL
Israel
Prior art keywords
hemihydrate
carbonitrile
piperidin
quinoline
trifluoromethyl
Prior art date
Application number
IL326278A
Other languages
Hebrew (he)
Inventor
Orue Analia Ivanna Chamorro
Sven Haferkamp
Dominique Anna Bock
Anna Mellor
Original Assignee
Merck Patent Gmbh
Orue Analia Ivanna Chamorro
Sven Haferkamp
Dominique Anna Bock
Anna Mellor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Orue Analia Ivanna Chamorro, Sven Haferkamp, Dominique Anna Bock, Anna Mellor filed Critical Merck Patent Gmbh
Publication of IL326278A publication Critical patent/IL326278A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
IL326278A 2023-08-09 2024-08-08 Crystalline form h1 of 5-((3r,55)-3-amino-5- trifluoromethyl-piperidin-1-yl)-quinoline-8-carbonitrile hemihydrate IL326278A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23190665 2023-08-09
PCT/EP2024/072511 WO2025032195A1 (en) 2023-08-09 2024-08-08 Crystalline form h1 of 5-((3r,55)-3-amino-5- trifluoromethyl-piperidin-1-yl)-quinoline-8-carbonitrile hemihydrate

Publications (1)

Publication Number Publication Date
IL326278A true IL326278A (en) 2026-04-01

Family

ID=87567618

Family Applications (1)

Application Number Title Priority Date Filing Date
IL326278A IL326278A (en) 2023-08-09 2024-08-08 Crystalline form h1 of 5-((3r,55)-3-amino-5- trifluoromethyl-piperidin-1-yl)-quinoline-8-carbonitrile hemihydrate

Country Status (6)

Country Link
KR (1) KR20260049276A (en)
CN (1) CN121646584A (en)
AU (1) AU2024319768A1 (en)
IL (1) IL326278A (en)
MX (1) MX2026001248A (en)
WO (1) WO2025032195A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3005766A1 (en) 2015-12-17 2017-06-22 Merck Patent Gmbh Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders

Also Published As

Publication number Publication date
CN121646584A (en) 2026-03-10
WO2025032195A1 (en) 2025-02-13
AU2024319768A1 (en) 2026-03-26
MX2026001248A (en) 2026-03-02
KR20260049276A (en) 2026-04-13

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