IL319078A - Process for the production of (1R,2S)-6,2-dimethyl-1-indenamine - Google Patents

Process for the production of (1R,2S)-6,2-dimethyl-1-indenamine

Info

Publication number
IL319078A
IL319078A IL319078A IL31907825A IL319078A IL 319078 A IL319078 A IL 319078A IL 319078 A IL319078 A IL 319078A IL 31907825 A IL31907825 A IL 31907825A IL 319078 A IL319078 A IL 319078A
Authority
IL
Israel
Prior art keywords
amino acid
different
variant
nuc
prt
Prior art date
Application number
IL319078A
Other languages
English (en)
Hebrew (he)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL319078A publication Critical patent/IL319078A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL319078A 2022-08-23 2023-08-17 Process for the production of (1R,2S)-6,2-dimethyl-1-indenamine IL319078A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22191617 2022-08-23
PCT/EP2023/072654 WO2024041961A2 (de) 2022-08-23 2023-08-17 Verfahren zur herstellung von (1r,2s)-2,6-dimethyl-1-indanamin

Publications (1)

Publication Number Publication Date
IL319078A true IL319078A (en) 2025-04-01

Family

ID=83049926

Family Applications (1)

Application Number Title Priority Date Filing Date
IL319078A IL319078A (en) 2022-08-23 2023-08-17 Process for the production of (1R,2S)-6,2-dimethyl-1-indenamine

Country Status (7)

Country Link
EP (1) EP4577665A2 (de)
JP (1) JP2025527617A (de)
KR (1) KR20250057811A (de)
CN (1) CN119768531A (de)
IL (1) IL319078A (de)
TW (1) TW202412627A (de)
WO (1) WO2024041961A2 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002065286A (ja) * 2000-08-29 2002-03-05 Nippon Steel Chem Co Ltd 光学活性（ｒ）‐１‐インダンアミド誘導体およびその製造方法
RS53108B (sr) * 2003-02-05 2014-06-30 Bayer Cropscience Ag. Amino-1,3,5-triazini n-zamenjeni sa hiralnim bicikličnim radikalima, proces za njihovu pripremu, njihova jedinjenja i njihova primena kao herbicida i regulatora rasta biljaka
CN108794339B (zh) * 2017-05-03 2023-01-20 上海朴颐化学科技有限公司 一种(1r,2s)-2,6-二甲基-1-胺基茚满的制备方法
EP3553179A1 (de) * 2018-04-12 2019-10-16 Universität Bielefeld Enantioselektive biokatalytische herstellung von 4-cyano-substituiertem 1-aminoindan und ozanimod

Also Published As

Publication number Publication date
WO2024041961A2 (de) 2024-02-29
KR20250057811A (ko) 2025-04-29
JP2025527617A (ja) 2025-08-22
TW202412627A (zh) 2024-04-01
EP4577665A2 (de) 2025-07-02
CN119768531A (zh) 2025-04-04
WO2024041961A3 (de) 2024-05-30

Similar Documents

Publication Publication Date Title
KR102947072B1 (ko) 개선된 트랜스아미나제 단백질을 코딩하는 핵산
IL319079A (en) Process for the production of (1R,2S)-6,2-dimethyl-1-indenamine using dynamic kinetic stereoisomer resolution
CN113825841B (zh) 经修饰的daao酶及其应用
CN114341344A (zh) 用于改进醛脱氢酶活性的工程微生物体和方法
CN118530962A (zh) 经修饰的苏氨酸转醛酶及其应用
AU2003221082A1 (en) Novel carbonyl reductase, gene encoding it and process for producing optically active alcohols using the same
CN111051506A (zh) 青霉素g酰化酶
IL319078A (en) Process for the production of (1R,2S)-6,2-dimethyl-1-indenamine
JP2025081303A (ja) 改変型グルタミン酸デヒドロゲナーゼ及びその使用
US11118200B2 (en) Method for preparing amines from aldehydes and ketones by biocatalysis
TW202423955A (zh) 編碼改良的脂酶蛋白質之核酸
KR20240125984A (ko) 변형된 글루타메이트 탈수소효소 및 이의 용도
TW202503053A (zh) 具有改良立體選擇性之脂酶及基於脂酶之掌性拆分方法
CN121646637A (zh) 具有增加的不对称还原胺化活性的突变型转氨酶以及涉及其的方法和用途
CN114277010A (zh) 转氨酶及其在制备光学纯手性胺中的应用
WO2005005648A1 (ja) 新規な光学活性カルボン酸の製造法
JP2007014251A (ja) ノルボルナン誘導体の加水分解に関与するｄｎａ
HK1185919B (zh) (r)-选择性胺化