IL316957A - MRNA encoding essential cyclic GMP–AMP synthase and lipid delivery vehicle for it - Google Patents
MRNA encoding essential cyclic GMP–AMP synthase and lipid delivery vehicle for itInfo
- Publication number
- IL316957A IL316957A IL316957A IL31695724A IL316957A IL 316957 A IL316957 A IL 316957A IL 316957 A IL316957 A IL 316957A IL 31695724 A IL31695724 A IL 31695724A IL 316957 A IL316957 A IL 316957A
- Authority
- IL
- Israel
- Prior art keywords
- constitutively
- same
- mrna encoding
- delivery vehicles
- cyclic gmp
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263341987P | 2022-05-13 | 2022-05-13 | |
| PCT/US2023/066974 WO2023220746A1 (en) | 2022-05-13 | 2023-05-12 | Mrna encoding a constitutively-active cyclic gmp-amp synthase and lipid delivery vehicles for same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL316957A true IL316957A (en) | 2025-01-01 |
Family
ID=86896168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL316957A IL316957A (en) | 2022-05-13 | 2023-05-12 | MRNA encoding essential cyclic GMP–AMP synthase and lipid delivery vehicle for it |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250255988A1 (enExample) |
| EP (1) | EP4522205A1 (enExample) |
| JP (1) | JP2025516637A (enExample) |
| KR (1) | KR20250023373A (enExample) |
| CN (1) | CN119451694A (enExample) |
| AU (1) | AU2023267834A1 (enExample) |
| CA (1) | CA3256940A1 (enExample) |
| IL (1) | IL316957A (enExample) |
| TW (1) | TW202402303A (enExample) |
| WO (1) | WO2023220746A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025253381A1 (en) * | 2024-06-04 | 2025-12-11 | Edity Therapeutics Ltd. | Cyclic gmp-amp synthase variants and use thereof |
| CN121495900B (zh) * | 2026-01-13 | 2026-04-24 | 泰兴合全药业有限公司 | 一种环状gmp-amp合成酶突变体及其用于制备2′,3′-环状单磷酸鸟苷-单磷酸腺苷的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3173092B1 (en) * | 2015-04-22 | 2019-06-26 | CureVac AG | Rna containing composition for treatment of tumor diseases |
| EP3814487A4 (en) * | 2018-06-29 | 2022-04-20 | President and Fellows of Harvard College | STRUCTURE OF THE HUMAN CGAS-DNA COMPLEX AND ITS USES |
| IL298765A (en) * | 2020-06-11 | 2023-02-01 | Etherna Immunotherapies Nv | Lipid nanoparticles |
-
2023
- 2023-05-12 AU AU2023267834A patent/AU2023267834A1/en active Pending
- 2023-05-12 JP JP2024566529A patent/JP2025516637A/ja active Pending
- 2023-05-12 CN CN202380050166.1A patent/CN119451694A/zh active Pending
- 2023-05-12 CA CA3256940A patent/CA3256940A1/en active Pending
- 2023-05-12 IL IL316957A patent/IL316957A/en unknown
- 2023-05-12 WO PCT/US2023/066974 patent/WO2023220746A1/en not_active Ceased
- 2023-05-12 US US18/864,462 patent/US20250255988A1/en active Pending
- 2023-05-12 KR KR1020247041462A patent/KR20250023373A/ko active Pending
- 2023-05-12 EP EP23732781.2A patent/EP4522205A1/en active Pending
- 2023-05-15 TW TW112117985A patent/TW202402303A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023267834A1 (en) | 2025-01-02 |
| JP2025516637A (ja) | 2025-05-30 |
| CA3256940A1 (en) | 2023-11-16 |
| WO2023220746A1 (en) | 2023-11-16 |
| EP4522205A1 (en) | 2025-03-19 |
| TW202402303A (zh) | 2024-01-16 |
| US20250255988A1 (en) | 2025-08-14 |
| CN119451694A (zh) | 2025-02-14 |
| KR20250023373A (ko) | 2025-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3256940A1 (en) | mRNA encoding a constituently active cyclic GMP-AMP synthase and associated lipid delivery vehicles | |
| US9473005B2 (en) | Stator core with a strucuture to improve assembly characteristics | |
| GB202205354D0 (en) | Fuel delivery | |
| IL304759A (en) | Lipids suitable for the transfer of nucleic acids | |
| MX2009009628A (es) | Motor con rotor lobular que tiene espacios de aire uniformes y no uniformes. | |
| PL1981465T3 (pl) | Metoda wytwarzania przyrządów do podawania środka przyjmowanego doustnie | |
| EP2368219A4 (en) | SYSTEMS AND METHODS FOR MODIFYING SERVICE STATUS OF GEOGRAPHIC DELIVERY AREAS FOR CARRIERS | |
| PL4426270T3 (pl) | Nanocząsteczki lipidowe do dostarczania oligonukleotydów | |
| IN2014DN07928A (enExample) | ||
| IL312431A (en) | Lipid nanoparticles for delivery of oligonucleotides | |
| ZA200706660B (en) | Belt for elevator system and method of manufacturing such a belt | |
| PH12012502188B1 (en) | Thioesterase and method for producing fatty acid or lipid using same | |
| EP4333810A4 (en) | Lipid DNA particle-mediated mRNA delivery to the pancreas | |
| IL213687A (en) | A system for administering drug doses | |
| GB202303641D0 (en) | Engagement measurement in in-flight entertainment systems | |
| MX2010001015A (es) | Dispositivo para procesar flujos y metodo del mismo. | |
| PL2064900T3 (pl) | Sposób przesyłania strumienia akustycznego pomiędzy wieloma terminalami | |
| EP2095593A4 (en) | METHOD AND ARRANGEMENT FOR MANAGING SERVICE REQUEST IN A MULTIMEDIA NETWORK | |
| IL316959A (en) | Nucleic acids encoding essential GMP-cyclic AMP synthase and means of delivering immunogens therefor | |
| HK40123918A (en) | Nucleic acids encoding a constitutively-active cyclic gmp-amp synthase and immunogenic delivery vehicles for same | |
| GB202502973D0 (en) | An apparatus for manufacturing delivery systems | |
| GB202306386D0 (en) | An apparatus for manufacturing delivery systems | |
| GB202506741D0 (en) | Fuel delivery system | |
| HK40070710A (en) | Synthetic lipids for mrna delivery | |
| HK40119907A (en) | Immunogenic mrna delivery vehicles |