IL314845A - Expression control using a regulatable INTRON - Google Patents
Expression control using a regulatable INTRONInfo
- Publication number
- IL314845A IL314845A IL314845A IL31484524A IL314845A IL 314845 A IL314845 A IL 314845A IL 314845 A IL314845 A IL 314845A IL 31484524 A IL31484524 A IL 31484524A IL 314845 A IL314845 A IL 314845A
- Authority
- IL
- Israel
- Prior art keywords
- regulatable
- intron
- expression control
- expression
- control
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1713545.0A GB201713545D0 (en) | 2017-08-23 | 2017-08-23 | Expression control using a regulatable intron |
| PCT/GB2018/052387 WO2019038544A1 (en) | 2017-08-23 | 2018-08-22 | EXPRESSION CONTROL USING AN ADJUSTABLE INTRON |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL314845A true IL314845A (en) | 2024-10-01 |
Family
ID=59996625
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL314845A IL314845A (en) | 2017-08-23 | 2018-08-22 | Expression control using a regulatable INTRON |
| IL272800A IL272800B2 (en) | 2017-08-23 | 2018-08-22 | Expression control using a regulatable intron |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL272800A IL272800B2 (en) | 2017-08-23 | 2018-08-22 | Expression control using a regulatable intron |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11492618B2 (enExample) |
| EP (1) | EP3673068A1 (enExample) |
| JP (2) | JP7830029B2 (enExample) |
| CN (2) | CN111566216B (enExample) |
| AU (2) | AU2018319637B2 (enExample) |
| GB (1) | GB201713545D0 (enExample) |
| IL (2) | IL314845A (enExample) |
| WO (1) | WO2019038544A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3171636A1 (en) * | 2020-03-26 | 2021-09-30 | Graham WHYTESIDE | Forskolin-inducible promoters and hypoxia-inducible promoters |
| US20230407327A1 (en) * | 2020-03-26 | 2023-12-21 | Asklepios Biopharmaceutical, Inc. | Inducible promoter for viral vector production |
| WO2021209743A1 (en) * | 2020-04-15 | 2021-10-21 | Synpromics Limited | Forskolin-inducible promoters and hypoxia-inducible promoters |
| JP7898267B2 (ja) * | 2021-10-20 | 2026-07-31 | リファインホールディングス株式会社 | 小胞体ストレス抑制剤、神経変性疾患予防改善剤および認知症の予防・進行防止・改善剤、並びに食品 |
| WO2025024776A2 (en) * | 2023-07-27 | 2025-01-30 | Duke University | Compositions comprising xbp1 fragments and methods of use in gene therapy |
| WO2026015884A1 (en) * | 2024-07-11 | 2026-01-15 | Helix Nanotechnologies Inc | Compositions comprising ire-1 binding sequences and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| JP4446057B2 (ja) * | 2002-08-28 | 2010-04-07 | 独立行政法人理化学研究所 | 生体刺激存在下でのｍＲＮＡのフレームシフトを利用した蛋白質の発現方法 |
| AU2003268356A1 (en) * | 2002-08-30 | 2004-03-19 | President And Fellows Of Harvard College | Methods and compositions for modulating xbp-1 activity |
| US20070111258A1 (en) * | 2005-06-22 | 2007-05-17 | Kaufman Randal J | Compositions and methods for modulating the acute phase response |
| US8227184B2 (en) * | 2008-01-14 | 2012-07-24 | President And Fellows Of Harvard College | Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity |
| WO2010151827A1 (en) * | 2009-06-25 | 2010-12-29 | Bayer Healthcare Llc | X-box binding proteins (xbp-1) variants and methods of using the same |
| US20200393447A1 (en) * | 2017-07-09 | 2020-12-17 | Thomas Hughes | Biosensors for measuring cell signaling in stressed and healthy cells |
| WO2021195491A2 (en) * | 2020-03-26 | 2021-09-30 | Asklepios Biopharmaceutical, Inc. | Inducible promoter for viral vector production |
-
2017
- 2017-08-23 GB GBGB1713545.0A patent/GB201713545D0/en not_active Ceased
-
2018
- 2018-08-22 US US16/640,434 patent/US11492618B2/en active Active
- 2018-08-22 WO PCT/GB2018/052387 patent/WO2019038544A1/en not_active Ceased
- 2018-08-22 AU AU2018319637A patent/AU2018319637B2/en active Active
- 2018-08-22 IL IL314845A patent/IL314845A/en unknown
- 2018-08-22 JP JP2020531824A patent/JP7830029B2/ja active Active
- 2018-08-22 CN CN201880068443.0A patent/CN111566216B/zh active Active
- 2018-08-22 CN CN202410738295.6A patent/CN118562839A/zh active Pending
- 2018-08-22 IL IL272800A patent/IL272800B2/en unknown
- 2018-08-22 EP EP18762597.5A patent/EP3673068A1/en active Pending
-
2022
- 2022-11-04 US US17/981,146 patent/US12600969B2/en active Active
-
2023
- 2023-07-06 JP JP2023111541A patent/JP2023118937A/ja active Pending
-
2025
- 2025-07-10 AU AU2025205352A patent/AU2025205352A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3673068A1 (en) | 2020-07-01 |
| JP2023118937A (ja) | 2023-08-25 |
| US11492618B2 (en) | 2022-11-08 |
| AU2018319637A1 (en) | 2020-03-12 |
| JP2020533019A (ja) | 2020-11-19 |
| US20200199593A1 (en) | 2020-06-25 |
| JP7830029B2 (ja) | 2026-03-16 |
| CA3073366A1 (en) | 2019-02-28 |
| IL272800B1 (en) | 2024-09-01 |
| NZ761945A (en) | 2024-09-27 |
| GB201713545D0 (en) | 2017-10-04 |
| CN111566216B (zh) | 2024-07-02 |
| IL272800B2 (en) | 2025-01-01 |
| WO2019038544A1 (en) | 2019-02-28 |
| AU2025205352A1 (en) | 2025-07-31 |
| IL272800A (en) | 2020-04-30 |
| US12600969B2 (en) | 2026-04-14 |
| AU2018319637B2 (en) | 2025-04-10 |
| CN118562839A (zh) | 2024-08-30 |
| CN111566216A (zh) | 2020-08-21 |
| US20230304003A1 (en) | 2023-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3827381C0 (en) | MULTIPLE QUANTUM BIT CONTROL | |
| GB2567256B (en) | Control of a seating arrangement | |
| GB201614099D0 (en) | A control interface | |
| AU201713813S (en) | A Lounge | |
| IL272800A (en) | Expression control using a regulatable INTRON | |
| GB2563856B (en) | Controlling a cycle | |
| SG11201802837TA (en) | A control valve | |
| AU201716579S (en) | A hitchlock | |
| PL3393325T3 (pl) | Zmywarka do naczyń oraz sposób sterowania nią | |
| GB2560368B (en) | A control unit | |
| HK40029725A (en) | Expression control using a regulatable intron | |
| PL3609382T3 (pl) | Zmywarka do naczyń | |
| GB2591558B (en) | Control arrangement | |
| ZA202100616B (en) | Control arrangement | |
| GB2562333B (en) | A windpost | |
| GB2563855B (en) | Controlling a cycle | |
| GB2570098B (en) | A workframe | |
| AU201812357S (en) | A swatchbox | |
| GB201721143D0 (en) | Control of a seating arrangement | |
| AU201811784S (en) | A Playsuit | |
| AU201811402S (en) | A Playsuit | |
| AU201715393S (en) | a playsuit | |
| AU201715392S (en) | a playsuit | |
| HU1700089V0 (hu) | Digitális vezérlésû LED-szalag | |
| AU201810323S (en) | A Playsuit |