IL313604A - Compositions and methods for reprogramming cells using circular RNA - Google Patents

Compositions and methods for reprogramming cells using circular RNA

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Publication number
IL313604A
IL313604A IL313604A IL31360424A IL313604A IL 313604 A IL313604 A IL 313604A IL 313604 A IL313604 A IL 313604A IL 31360424 A IL31360424 A IL 31360424A IL 313604 A IL313604 A IL 313604A
Authority
IL
Israel
Prior art keywords
compositions
methods
circular rna
cellular reprogramming
reprogramming
Prior art date
Application number
IL313604A
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English (en)
Hebrew (he)
Original Assignee
Elevatebio Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elevatebio Tech Inc filed Critical Elevatebio Tech Inc
Publication of IL313604A publication Critical patent/IL313604A/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
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  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Transplantation (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL313604A 2021-12-20 2022-12-19 Compositions and methods for reprogramming cells using circular RNA IL313604A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163291645P 2021-12-20 2021-12-20
PCT/US2022/081898 WO2023122517A2 (en) 2021-12-20 2022-12-19 Compositions and methods for cellular reprogramming using circular rna

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IL313604A true IL313604A (en) 2024-08-01

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IL313604A IL313604A (en) 2021-12-20 2022-12-19 Compositions and methods for reprogramming cells using circular RNA

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US (1) US20240327799A1 (https=)
EP (1) EP4453205A4 (https=)
JP (1) JP2024547057A (https=)
KR (1) KR20240123826A (https=)
CN (1) CN118574930A (https=)
AU (1) AU2022420484A1 (https=)
CA (1) CA3240645A1 (https=)
IL (1) IL313604A (https=)
TW (1) TW202330907A (https=)
WO (1) WO2023122517A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025106897A1 (en) * 2023-11-16 2025-05-22 Colossal Biosciences Inc. Methods and compositions for creating induced pluripotent stem cells
WO2025240429A1 (en) * 2024-05-13 2025-11-20 Colossal Biosciences Inc. Methods and compositions for creating elephant induced pluripotent stem cells
CN118638781B (zh) * 2024-05-27 2025-05-16 毕昇(北京)生物科技有限公司 使用环状RNA和microRNA进行细胞重编程的组合物和方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8496941B2 (en) * 2009-06-03 2013-07-30 National Institute Of Advanced Industrial Science And Technology Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
US20120301438A1 (en) * 2009-09-14 2012-11-29 The Johns Hopkins University Reprogramming Blood Cells to Pluripotent and Multipotent Stem Cells
PL2852671T3 (pl) * 2012-05-21 2019-06-28 The Regents Of The University Of California Wytwarzanie ludzkich komórek ips z użyciem syntetycznego samoreplikującego się rna
BR112021023411A2 (pt) * 2019-05-22 2022-02-01 Massachusetts Inst Technology Composições e métodos de rna circular
CA3217001A1 (en) * 2021-04-27 2022-11-03 Matthew Angel Circular rna
US20230042860A1 (en) * 2021-07-15 2023-02-09 Turn Biotechnologies, Inc. Polycistronic expression vectors

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US20240327799A1 (en) 2024-10-03
TW202330907A (zh) 2023-08-01
EP4453205A2 (en) 2024-10-30
CN118574930A (zh) 2024-08-30
AU2022420484A1 (en) 2024-06-13
CA3240645A1 (en) 2023-06-29
EP4453205A4 (en) 2025-12-17
KR20240123826A (ko) 2024-08-14
JP2024547057A (ja) 2024-12-26
WO2023122517A2 (en) 2023-06-29
WO2023122517A3 (en) 2023-08-03

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