IL313551A - תכשירים למתן משופר של אפינפרין ומטרים תרופה - Google Patents

Info

Publication number

IL313551A

IL313551A IL313551A IL31355124A IL313551A IL 313551 A IL313551 A IL 313551A IL 313551 A IL313551 A IL 313551A IL 31355124 A IL31355124 A IL 31355124A IL 313551 A IL313551 A IL 313551A

Authority

IL

Israel

Prior art keywords

pharmaceutical composition

composition according

epinephrine

polymeric matrix

film

Prior art date

2017-09-27

Links

• Espacenet
• Global Dossier
• Discuss

• UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 title claims description 193
• 229930182837 (R)-adrenaline Natural products 0.000 title claims description 154
• 229960005139 epinephrine Drugs 0.000 title claims description 154
• 239000003814 drug Substances 0.000 title description 62
• 229940079593 drug Drugs 0.000 title description 58
• 238000002360 preparation method Methods 0.000 title description 8
• 239000010408 film Substances 0.000 claims description 213
• -1 cinnamic acid ester Chemical class 0.000 claims description 99
• 239000008194 pharmaceutical composition Substances 0.000 claims description 86
• 239000000203 mixture Substances 0.000 claims description 82
• 239000011159 matrix material Substances 0.000 claims description 81
• 229920000642 polymer Polymers 0.000 claims description 66
• 239000003961 penetration enhancing agent Substances 0.000 claims description 49
• RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 42
• 108060003345 Adrenergic Receptor Proteins 0.000 claims description 34
• 102000017910 Adrenergic receptor Human genes 0.000 claims description 34
• 229940002612 prodrug Drugs 0.000 claims description 33
• 239000000651 prodrug Substances 0.000 claims description 33
• 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims description 32
• 229930002886 farnesol Natural products 0.000 claims description 32
• 229940043259 farnesol Drugs 0.000 claims description 32
• CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims description 32
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 23
• 230000001965 increasing effect Effects 0.000 claims description 23
• 239000000412 dendrimer Substances 0.000 claims description 22
• NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 21
• 239000005770 Eugenol Substances 0.000 claims description 21
• UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 21
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• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 20
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• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 19
• 229930015704 phenylpropanoid Natural products 0.000 claims description 18
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• 238000000034 method Methods 0.000 claims description 17
• OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 16
• 235000020778 linoleic acid Nutrition 0.000 claims description 16
• OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 16
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• 229920000587 hyperbranched polymer Polymers 0.000 claims description 11
• 229920003169 water-soluble polymer Polymers 0.000 claims description 11
• SCCDQYPEOIRVGX-UHFFFAOYSA-N Acetyleugenol Chemical compound COC1=CC(CC=C)=CC=C1OC(C)=O SCCDQYPEOIRVGX-UHFFFAOYSA-N 0.000 claims description 10
• 108010010803 Gelatin Proteins 0.000 claims description 10
• 229920000159 gelatin Polymers 0.000 claims description 10
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• 239000002202 Polyethylene glycol Substances 0.000 claims description 9
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• 229920001223 polyethylene glycol Polymers 0.000 claims description 8
• ZMQAAUBTXCXRIC-UHFFFAOYSA-N safrole Chemical compound C=CCC1=CC=C2OCOC2=C1 ZMQAAUBTXCXRIC-UHFFFAOYSA-N 0.000 claims description 8
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• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
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• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 6
• XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 6
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• RGIBXDHONMXTLI-UHFFFAOYSA-N chavicol Chemical compound OC1=CC=C(CC=C)C=C1 RGIBXDHONMXTLI-UHFFFAOYSA-N 0.000 claims description 6
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• 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 6
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• 235000019698 starch Nutrition 0.000 claims description 6
• 235000007586 terpenes Nutrition 0.000 claims description 6
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• 229920001661 Chitosan Polymers 0.000 claims description 5
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 5
• 229920000591 gum Polymers 0.000 claims description 5
• 239000007788 liquid Substances 0.000 claims description 5
• 229930004725 sesquiterpene Natural products 0.000 claims description 5
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• 102000009027 Albumins Human genes 0.000 claims description 4
• 108010088751 Albumins Proteins 0.000 claims description 4
• 229920002907 Guar gum Polymers 0.000 claims description 4
• 229920000084 Gum arabic Polymers 0.000 claims description 4
• 208000010496 Heart Arrest Diseases 0.000 claims description 4
• 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
• 239000000205 acacia gum Substances 0.000 claims description 4
• 230000017531 blood circulation Effects 0.000 claims description 4
• 239000002552 dosage form Substances 0.000 claims description 4
• 235000010417 guar gum Nutrition 0.000 claims description 4
• 239000000665 guar gum Substances 0.000 claims description 4
• 229960002154 guar gum Drugs 0.000 claims description 4
• 239000004584 polyacrylic acid Substances 0.000 claims description 4
• 239000007921 spray Substances 0.000 claims description 4
• 208000003663 ventricular fibrillation Diseases 0.000 claims description 4
• 229920001285 xanthan gum Polymers 0.000 claims description 4
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• 239000000230 xanthan gum Substances 0.000 claims description 4
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• KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 3
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
• IAZKGRRJAULWNS-UHFFFAOYSA-N Chavicol Natural products OC1=CC=C(CCC=C)C=C1 IAZKGRRJAULWNS-UHFFFAOYSA-N 0.000 claims description 3
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 3
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• AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims description 3
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• CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
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