IL312832A - Methods and compositions for detecting receptor-ligand specificity by feeding transgenic cells - Google Patents

Methods and compositions for detecting receptor-ligand specificity by feeding transgenic cells

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Publication number
IL312832A
IL312832A IL312832A IL31283224A IL312832A IL 312832 A IL312832 A IL 312832A IL 312832 A IL312832 A IL 312832A IL 31283224 A IL31283224 A IL 31283224A IL 312832 A IL312832 A IL 312832A
Authority
IL
Israel
Prior art keywords
discovery
receptor
compositions
methods
engineered cell
Prior art date
Application number
IL312832A
Other languages
English (en)
Hebrew (he)
Inventor
Howard Y Chang
Ansuman Satpathy
Quanming Shi
Bingfei Yu
Original Assignee
Univ Leland Stanford Junior
Howard Y Chang
Ansuman Satpathy
Quanming Shi
Bingfei Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Howard Y Chang, Ansuman Satpathy, Quanming Shi, Bingfei Yu filed Critical Univ Leland Stanford Junior
Publication of IL312832A publication Critical patent/IL312832A/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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IL312832A 2021-12-06 2022-12-05 Methods and compositions for detecting receptor-ligand specificity by feeding transgenic cells IL312832A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163286507P 2021-12-06 2021-12-06
US202263382860P 2022-11-08 2022-11-08
PCT/US2022/080915 WO2023107886A1 (en) 2021-12-06 2022-12-05 Methods and compositions for discovery of receptor-ligand specificity by engineered cell entry

Publications (1)

Publication Number Publication Date
IL312832A true IL312832A (en) 2024-07-01

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IL312832A IL312832A (en) 2021-12-06 2022-12-05 Methods and compositions for detecting receptor-ligand specificity by feeding transgenic cells

Country Status (8)

Country Link
US (1) US20250027073A1 (https=)
EP (1) EP4444878A4 (https=)
JP (1) JP2024542811A (https=)
KR (1) KR20240112950A (https=)
AU (1) AU2022405508A1 (https=)
CA (1) CA3238531A1 (https=)
IL (1) IL312832A (https=)
WO (1) WO2023107886A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4281569A4 (en) * 2021-01-25 2025-04-02 The Regents Of The University Of California Methods and compositions for labeling and selecting antigen-specific T cells
WO2024081820A1 (en) * 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
CN121844055A (zh) * 2023-08-16 2026-04-10 深圳市济因生物科技有限公司 一种病毒载体及其在感染b细胞中的应用
WO2025072615A1 (en) 2023-09-29 2025-04-03 Orbital Therapeutics, Inc. Improved methods of making rna by splinted ligation and compositions thereof
WO2025212851A2 (en) 2024-04-03 2025-10-09 Orbital Therapeutics, Inc. mRNA COMPOSITIONS AND USES THEREOF IN VARICELLA ZOSTER VIRUS VACCINES
WO2025259931A1 (en) 2024-06-14 2025-12-18 Orbital Therapeutics, Inc. Compositions and methods for rna circularization
WO2026006203A2 (en) 2024-06-24 2026-01-02 Orbital Therapeutics, Inc. Compositions and methods for making circular rna
WO2026006687A1 (en) 2024-06-28 2026-01-02 Orbital Therapeutics, Inc. Circular rna compositions and uses thereof for diseases caused by varicella-zoster virus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
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JP7799945B2 (ja) * 2017-09-22 2026-01-16 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック 変異型ウイルスタンパク質
US11535865B2 (en) * 2018-02-06 2022-12-27 The Broad Institute, Inc. Co-packaging to mitigate intermolecular recombination
JP7658584B2 (ja) * 2019-05-23 2025-04-08 マサチューセッツ インスティテュート オブ テクノロジー リガンドの発見およびレトロウイルス表面ディスプレーを介した遺伝子送達
US12195723B2 (en) * 2019-11-08 2025-01-14 The Broad Institute, Inc. Engineered antigen presenting cells and uses thereof
CN115243713A (zh) * 2020-03-05 2022-10-25 埃克苏马生物技术公司 用于递送修饰的淋巴细胞聚集体的方法和组合物

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EP4444878A4 (en) 2026-04-29
CA3238531A1 (en) 2023-06-15
WO2023107886A1 (en) 2023-06-15
US20250027073A1 (en) 2025-01-23
EP4444878A1 (en) 2024-10-16
AU2022405508A1 (en) 2024-05-30
KR20240112950A (ko) 2024-07-19
JP2024542811A (ja) 2024-11-15

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