IL312762A - ANTISENSE OLIGONUCLEOTIDES (ASO) for efficient and accurate RNA editing with an endogenous adaminase that acts on RNA (ADAR) - Google Patents
ANTISENSE OLIGONUCLEOTIDES (ASO) for efficient and accurate RNA editing with an endogenous adaminase that acts on RNA (ADAR)Info
- Publication number
- IL312762A IL312762A IL312762A IL31276224A IL312762A IL 312762 A IL312762 A IL 312762A IL 312762 A IL312762 A IL 312762A IL 31276224 A IL31276224 A IL 31276224A IL 312762 A IL312762 A IL 312762A
- Authority
- IL
- Israel
- Prior art keywords
- rna
- adar
- aso
- efficient
- antisense oligonucleotides
- Prior art date
Links
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 title 1
- 102000055025 Adenosine deaminases Human genes 0.000 title 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 title 1
- 239000000074 antisense oligonucleotide Substances 0.000 title 1
- 238000012230 antisense oligonucleotides Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21211372 | 2021-11-30 | ||
| PCT/EP2022/083711 WO2023099494A1 (en) | 2021-11-30 | 2022-11-29 | Antisense oligonucleotides (aso) for efficient and precise rna editing with endogenous adenosine deaminase acting on rna (adar) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL312762A true IL312762A (en) | 2024-07-01 |
Family
ID=78820190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL312762A IL312762A (en) | 2021-11-30 | 2022-11-29 | ANTISENSE OLIGONUCLEOTIDES (ASO) for efficient and accurate RNA editing with an endogenous adaminase that acts on RNA (ADAR) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230235329A1 (https=) |
| EP (1) | EP4441216A1 (https=) |
| JP (1) | JP2024544067A (https=) |
| KR (1) | KR20240111752A (https=) |
| CN (1) | CN118355119A (https=) |
| AU (1) | AU2022399905A1 (https=) |
| CA (1) | CA3238033A1 (https=) |
| IL (1) | IL312762A (https=) |
| WO (1) | WO2023099494A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024114908A1 (en) * | 2022-11-30 | 2024-06-06 | Eberhard Karls Universität Tübingen | Chemically modified antisense oligonucleotides (asos) and compositions comprising the same for rna editing |
| AU2024325709A1 (en) * | 2023-08-15 | 2026-01-29 | Airna Corporation | Chemically modified antisense oligonucleotides (asos) and compositions for rna editing |
| WO2025073902A1 (en) * | 2023-10-06 | 2025-04-10 | Eberhard Karls Universität Tübingen | Chemical and sequence optimisation of antisense oligonucleotides for adar-mediated rna editing |
| WO2025172372A1 (en) | 2024-02-12 | 2025-08-21 | Airna Corporation | Conjugate for targeted delivery of an antisense oligonucleotide |
| WO2025242018A1 (zh) * | 2024-05-20 | 2025-11-27 | 时夕(广州)生物科技有限公司 | 一种经修饰的向导agRNA |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10941402B2 (en) | 2016-09-01 | 2021-03-09 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded RNA-editing oligonucleotides |
| WO2020001793A1 (en) | 2018-06-29 | 2020-01-02 | Eberhard-Karls-Universität Tübingen | Artificial nucleic acids for rna editing |
| CA3158528A1 (en) * | 2019-12-23 | 2021-07-01 | Jim SWILDENS | Antisense oligonucleotides for nucleotide deamination in the treatment of stargardt disease |
-
2022
- 2022-11-29 WO PCT/EP2022/083711 patent/WO2023099494A1/en not_active Ceased
- 2022-11-29 EP EP22823405.0A patent/EP4441216A1/en active Pending
- 2022-11-29 CN CN202280079432.9A patent/CN118355119A/zh active Pending
- 2022-11-29 AU AU2022399905A patent/AU2022399905A1/en active Pending
- 2022-11-29 CA CA3238033A patent/CA3238033A1/en active Pending
- 2022-11-29 KR KR1020247016720A patent/KR20240111752A/ko active Pending
- 2022-11-29 JP JP2024532266A patent/JP2024544067A/ja active Pending
- 2022-11-29 IL IL312762A patent/IL312762A/en unknown
- 2022-11-30 US US18/071,999 patent/US20230235329A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024544067A (ja) | 2024-11-27 |
| US20230235329A1 (en) | 2023-07-27 |
| WO2023099494A1 (en) | 2023-06-08 |
| CA3238033A1 (en) | 2023-06-08 |
| AU2022399905A1 (en) | 2024-05-23 |
| WO2023099494A9 (en) | 2024-10-17 |
| EP4441216A1 (en) | 2024-10-09 |
| KR20240111752A (ko) | 2024-07-17 |
| CN118355119A (zh) | 2024-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL312762A (en) | ANTISENSE OLIGONUCLEOTIDES (ASO) for efficient and accurate RNA editing with an endogenous adaminase that acts on RNA (ADAR) | |
| PH12022550059A1 (en) | Targeted rna editing by leveraging endogenous adar using engineered rnas | |
| PH12021552613A1 (en) | METHODS AND COMPOSITIONS FOR EDITING RNAs | |
| PH12021550805A1 (en) | Methods and Compositions for Editing RNAs | |
| Zhang et al. | Life without A tail: new formats of long noncoding RNAs | |
| GB202011428D0 (en) | Antisense oligonucleotides for RNA editing | |
| MX2013009815A (es) | Derivados de fosforoamidato de 5-fluoro-2'-desoxiuridina para uso en el tratamiento contra el cancer. | |
| GB201901873D0 (en) | Antisense oligonucleotides for nucleic acid editing | |
| BRPI0418463A (pt) | métodos de inibir expressão de stat3 humano, de induzir apoptose em células de carcinoma do pulmão, e de inibir crescimento de tumor de linfoma de células t, tumor alcl, e tumor mieloma múltiplo em um animal | |
| BRPI0922355A2 (pt) | ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso de um ácido nucléico, complexo de rna e uso do complexo de rna | |
| Yang et al. | MicroRNAs and apoptosis: implications in the molecular therapy of human disease | |
| RU2019124314A (ru) | Сопряженные антисмысловые соединения и их применение | |
| WO2003100017A3 (en) | Oligonucleotides having modified nucleoside units | |
| GB202304363D0 (en) | Chemically modified antisense oligonucleotides for use in RNA editing | |
| EP4277990A4 (en) | TARGETED RNA EDITING BY USING ENDOGENOUS ADAR USING MANIPULATED RNAS | |
| ATE442986T1 (de) | Systeme zur nutzlastverkleidung bei luftfahrzeugen und entsprechende verfahren | |
| EP3972571A4 (en) | METHOD USING PHOTOTHERMAL NANOPARTICLES IN RAPID NUCLEIC ACID AMPLIFICATION AND PHOTOTHERMAL NANOPARTICLES | |
| HK40117606A (en) | Antisense oligonucleotides (aso) for efficient and precise rna editing with endogenous adenosine deaminase acting on rna (adar) | |
| HK40109733A (en) | Antisense oligonucleotides (aso) for efficient and precise rna editing with endogenous adenosine deaminase acting on rna (adar) | |
| Lee et al. | Selection of reference genes for quantitative real-time polymerase chain reaction in porcine embryos | |
| Ge et al. | Regulation of pre-mRNA splicing in Xenopus oocytes by targeted 2′-O-methylation | |
| IL320984A (en) | Chemically modified antisense oligonucleotides (ASOS) and compositions comprising them for RNA editing | |
| BR112021020406A2 (pt) | Sistemas de edição de genes para modificar um gene scn9a ou scn10a e métodos de uso dos mesmos | |
| WO2004022782A3 (en) | Compositions and methods for tissue specific or inducible inhibition of gene expression | |
| Feng et al. | A directed Monte Carlo solution of linear stochastic algebraic system of equations |