IL307992B2 - Isoxazoline parasiticide formulations and methodsfor treating blepharitis - Google Patents

Isoxazoline parasiticide formulations and methodsfor treating blepharitis

Info

Publication number
IL307992B2
IL307992B2 IL307992A IL30799223A IL307992B2 IL 307992 B2 IL307992 B2 IL 307992B2 IL 307992 A IL307992 A IL 307992A IL 30799223 A IL30799223 A IL 30799223A IL 307992 B2 IL307992 B2 IL 307992B2
Authority
IL
Israel
Prior art keywords
composition
use according
patient
isoxazoline parasiticide
delivered
Prior art date
Application number
IL307992A
Other languages
Hebrew (he)
Other versions
IL307992B1 (en
IL307992A (en
Inventor
Shawn D Hickok
Bobak Robert Azamian
Joseph G Vehige
Douglas Michael Ackermann
Original Assignee
Tarsus Pharmaceuticals Inc
Shawn D Hickok
Bobak Robert Azamian
Joseph G Vehige
Douglas Michael Ackermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66814591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL307992(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tarsus Pharmaceuticals Inc, Shawn D Hickok, Bobak Robert Azamian, Joseph G Vehige, Douglas Michael Ackermann filed Critical Tarsus Pharmaceuticals Inc
Publication of IL307992A publication Critical patent/IL307992A/en
Publication of IL307992B1 publication Critical patent/IL307992B1/en
Publication of IL307992B2 publication Critical patent/IL307992B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (53)

1. 307992/ -42- Claims 1. An ophthalmic composition for use in reducing eyelid collarettes in a human patient, wherein the composition comprises an effective amount of an isoxazoline parasiticide and a pharmaceutically acceptable vehicle, and wherein the composition is topically delivered to one or more of the eyes, eyelids, or eyelashes of the patient.
2. The composition for use according to Claim 1, wherein the ophthalmic composition comprises an eye drop.
3. The composition for use according to Claim 1 or 2, wherein the composition does not include any essential oils.
4. The composition for use according to any one of the preceding claims, wherein the isoxazoline parasiticide is selected from the group consisting of: fluralaner, sarolaner, lotilaner, afoxolaner and fluxametamide.
5. The composition for use according to Claim 4, wherein the isoxazoline parasiticide comprises lotilaner.
6. The composition for use according to any one of the preceding claims, wherein the isoxazoline parasiticide is the sole active ingredient of the composition.
7. The composition for use according to any one of the preceding claims, wherein the composition comprises a castor oil, but not a polysorbate.
8. An ophthalmic composition for use in reducing eyelid collarettes in a human patient, wherein the composition comprises an effective amount of an isoxazoline parasiticide, a pharmaceutically acceptable vehicle, and a castor oil, wherein the isoxazoline parasiticide is the sole active ingredient of the composition, and wherein the composition is topically delivered to one or more of the eyes, eyelids, or eyelashes of the patient. -43-
9. The composition for use according to Claim 8, wherein the patient’s eyes are closed upon topically administering the composition, such that the composition contacts orifices of Meibomian glands of the patient and outside of eyelid margins of the patient.
10. The composition for use according to Claim 9, wherein the composition is intended to be spread onto the eyelashes and follicles of the eyelashes.
11. The composition for use according to Claim 10, wherein the composition is intended to be spread onto the eyelashes and follicles of the eyelashes with an applicator.
12. The composition for use according to any one of Claims 8 to 11, wherein the composition comprises from 0.001% to 1% of the isoxazoline parasiticide.
13. The composition for use according to any one of Claims 8 to 12, wherein the composition is intended to be administered at least once daily for at least 2 weeks.
14. The composition for use according to Claim 13, wherein the composition is intended to be administered at least once daily for at least 4 weeks.
15. The composition for use according to any one of Claims 8 to 14, wherein the isoxazoline parasiticide comprises lotilaner.
16. An ophthalmic composition for use in reducing eyelid collarettes in a human patient, wherein the composition comprises an effective amount of an isoxazoline parasiticide and a pharmaceutically acceptable vehicle, wherein the isoxazoline parasiticide is the sole active ingredient of the composition, wherein the composition is topically delivered to one or more of the eyes, eyelids, or eyelashes of the patient, and wherein the volume of the composition delivered is less than 100 microliters.
17. The composition for use according to Claim 16, wherein the composition is intended to be administered following a first assessment of a quantity of Demodex mites on an anatomical structure of the patient indicating the quantity of Demodex mites is greater than a predetermined value.
18. The composition for use according to Claim 17, wherein the predetermined value is 1 mite per lash. -44-
19. The composition for use according to Claim 16, wherein the composition is intended to be administered following a first assessment of a quantity of collarettes on an anatomical structure of the patient indicating the quantity of collarettes is greater than a predetermined value.
20. The composition for use according to Claim 19, wherein the predetermined value is 3 collarettes.
21. The composition for use according to Claim 19, wherein the predetermined value is 10 collarettes.
22. The composition for use according to any one of Claims 16 to 21, wherein the isoxazoline parasiticide comprises lotilaner.
23. A topical composition for use in treating an ocular Demodex infestation in a human patient, wherein the composition comprises an effective amount of an isoxazoline parasiticide and a pharmaceutically acceptable vehicle, and wherein the composition is formulated as a gel, an ointment, or a cream.
24. The composition for use according to Claim 23, wherein the composition is topically delivered to one or more of the eyes, eyelids, or eyelashes of the patient.
25. The composition for use according to Claim 23 or 24, wherein from 0.01% to 1% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
26. The composition for use according to Claim 25, wherein from 0.15% to 0.40% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
27. The composition for use according to Claim 26, wherein 0.25% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
28. The composition for use according to any one any one of Claims 23 to 27, wherein the isoxazoline parasiticide is selected from the group consisting of: fluralaner, sarolaner, lotilaner, afoxolaner and fluxametamide.
29. The composition for use according to Claim 28, wherein the isoxazoline parasiticide comprises lotilaner. -45-
30. The composition for use according to any one of Claims 23 to 29, wherein the composition does not include any essential oils.
31. The composition for use according to any one of Claims 23 to 30, wherein the composition does not include tea tree oil.
32. The composition for use according to any one of Claims 23 to 31, wherein the isoxazoline parasiticide is the sole active ingredient of the composition.
33. The composition for use according to any one of Claims 23 to 32, wherein the composition is topically administered at least once daily for at least 2 weeks.
34. The composition for use according to Claim 33, wherein the composition is topically administered at least once daily for at least 4 weeks.
35. The composition for use according to Claim 34, wherein the composition is topically administered at least once daily for at least 6 weeks.
36. The composition for use according to any Claim 33, wherein the composition is topically administered at least twice daily for at least 2 weeks.
37. The composition for use according to any one of Claims 23 to 36, wherein the composition comprises a castor oil.
38. The composition for use according to Claim 37, wherein the castor oil comprises hydrogenated castor oil.
39. A dermatological composition for use in treating rosacea in a human patient, wherein the composition comprises an effective amount of an isoxazoline parasiticide and a pharmaceutically acceptable vehicle, and wherein the composition is formulated as a gel, an ointment, or a cream.
40. The composition for use according to Claim 39, wherein the composition is topically delivered to one or more of the eyes, eyelids, or eyelashes of the patient.
41. The composition for use according to Claim 39 or 40, wherein from 0.001% to 10% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
42. The composition for use according to Claim 41, wherein from 0.1% to 10% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient. -46-
43. The composition for use according to Claim 41, wherein from 0.01% to 5% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
44. The composition for use according to Claim 43, wherein 2% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
45. The composition for use according to Claim 43, wherein 1% of the isoxazoline parasiticide with respect to the total weight of the composition is delivered to the patient.
46. The composition for use according to any one any one of Claims 39 to 45, wherein the isoxazoline parasiticide is selected from the group consisting of: fluralaner, sarolaner, lotilaner, afoxolaner and fluxametamide.
47. The composition for use according to Claim 46, wherein the isoxazoline parasiticide comprises lotilaner.
48. The composition for use according to any one of Claims 39 to 47, wherein the composition does not include any essential oils.
49. The composition for use according to any one of Claims 39 to 48, wherein the isoxazoline parasiticide is the sole active ingredient of the composition.
50. The composition for use according to any one of Claims 39 to 49, wherein the composition is topically administered at least once daily for at least 2 weeks.
51. The composition for use according to Claim 50, wherein the composition is topically administered at least once daily for at least 4 weeks.
52. The composition for use according to Claim 51, wherein the composition is topically administered at least once daily for at least 6 weeks.
53. The composition for use according to Claim 50, wherein the composition is topically administered at least twice daily for at least 2 weeks.
IL307992A 2017-12-15 2018-12-14 Isoxazoline parasiticide formulations and methodsfor treating blepharitis IL307992B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762599213P 2017-12-15 2017-12-15
US201862615855P 2018-01-10 2018-01-10
US201862626612P 2018-02-05 2018-02-05
US201862689787P 2018-06-25 2018-06-25
US201862746498P 2018-10-16 2018-10-16
PCT/US2018/065849 WO2019118928A1 (en) 2017-12-15 2018-12-14 Isoxazoline parasiticide formulations and methods for treating blepharitis

Publications (3)

Publication Number Publication Date
IL307992A IL307992A (en) 2023-12-01
IL307992B1 IL307992B1 (en) 2024-11-01
IL307992B2 true IL307992B2 (en) 2025-03-01

Family

ID=66814591

Family Applications (3)

Application Number Title Priority Date Filing Date
IL275339A IL275339B2 (en) 2017-12-15 2018-12-14 Parasitic formulations containing isoxazoline and methods for treating blepharitis
IL307992A IL307992B2 (en) 2017-12-15 2018-12-14 Isoxazoline parasiticide formulations and methodsfor treating blepharitis
IL316352A IL316352A (en) 2017-12-15 2018-12-14 Isoxazoline parasiticide formulations and methodsfor treating blepharitis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL275339A IL275339B2 (en) 2017-12-15 2018-12-14 Parasitic formulations containing isoxazoline and methods for treating blepharitis

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL316352A IL316352A (en) 2017-12-15 2018-12-14 Isoxazoline parasiticide formulations and methodsfor treating blepharitis

Country Status (19)

Country Link
US (14) US10835517B2 (en)
EP (2) EP4397375A3 (en)
JP (3) JP7866369B2 (en)
KR (4) KR20250065422A (en)
CN (3) CN119157876A (en)
AU (3) AU2018385766B2 (en)
BR (1) BR112020012018A2 (en)
CA (1) CA3085787A1 (en)
DK (1) DK3723739T3 (en)
ES (1) ES2981130T3 (en)
FI (1) FI3723739T3 (en)
HU (1) HUE067461T2 (en)
IL (3) IL275339B2 (en)
MX (2) MX2020006309A (en)
PL (1) PL3723739T3 (en)
PT (1) PT3723739T (en)
SI (1) SI3723739T1 (en)
WO (1) WO2019118928A1 (en)
ZA (1) ZA202004155B (en)

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